BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs

Circ- calm4 Serves as an miR-337-3p Sponge to Regulate Myo10 (Myosin 10) and Promote Pulmonary Artery Smooth Muscle Proliferation

(2020) Junting Zhang et al.   HYPERTENSION

Roles of Zinc Finger Protein 423 in Proliferation and Invasion of Cholangiocarcinoma through Oxidative Stress

(2019) Timpika Chaiprasert et al.   Biomolecules

BDE-209 induces autophagy and apoptosis via IRE1α/Akt/mTOR signaling pathway in human umbilical vein endothelial cells

(2019) Yun Hou et al.   ENVIRONMENTAL POLLUTION

Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension

(2019) Min Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy

(2018) Jiwei Wang et al.   Autophagy

GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases

(2018) Anton M. Jetten   CELLULAR AND MOLECULAR LIFE SCIENCES

Developing in 3D: the role of CTCF in cell differentiation

(2018) Rodrigo G. Arzate-Mejía et al.   DEVELOPMENT

Transcriptional and post-transcriptional regulation of autophagy in the yeastSaccharomyces cerevisiae

(2018) Elizabeth Delorme-Axford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study

(2018) Javier Milara et al.   THORAX

Inhibition of breast cancer cell growth by methyl pyropheophenylchlorin photodynamic therapy is mediated though endoplasmic reticulum stress-induced autophagy in vitro and vivo

(2018) Jiang Zhu et al.   Cancer Medicine

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats

(2018) Rui-Lan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia

(2017) Yuanzhou He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylated cyclophilin A is a major mediator in hypoxia-induced autophagy and pulmonary vascular angiogenesis

(2017) Min Mao et al.   JOURNAL OF HYPERTENSION

MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling

(2017) Cui Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Persistent Challenges in Pediatric Pulmonary Hypertension

(2016) Rachel K. Hopper et al.   CHEST

Cocaine-mediated microglial activation involves the ER stress-autophagy axis

(2015) Ming-Lei Guo et al.   Autophagy

VEGF-activated miR-144 regulates autophagic survival of prostate cancer cells against Cisplatin

(2015) Feng Liu et al.   TUMOR BIOLOGY

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension

(2014) Masayuki Koyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Apelin inhibits the proliferation and migration of rat PASMCsviathe activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia

(2014) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells

(2014) Haifeng Jin et al.   JOURNAL OF PINEAL RESEARCH

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Autophagy: A Crucial Moderator of Redox Balance, Inflammation, and Apoptosis in Lung Disease

(2013) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

(2013) Lu Long et al.   CIRCULATION RESEARCH

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome ofETV6-RUNX1negative B precursor acute lymphoblastic leukemia

(2013) Lena Harder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma

(2013) Wen Zhou et al.   Molecular Cancer

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization

(2013) T Rivera Vargas et al.   ONCOGENE

Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension

(2012) Peter Dromparis et al.   CIRCULATION

Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries

(2011) J. Milara et al.   EUROPEAN RESPIRATORY JOURNAL

Key Role of 15-Lipoxygenase/15-Hydroxyeicosatetraenoic Acid in Pulmonary Vascular Remodeling and Vascular Angiogenesis Associated With Hypoxic Pulmonary Hypertension

(2011) Cui Ma et al.   HYPERTENSION

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques

(2009) Pravin B. Sehgal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Enhanced expression ofp210BCR/ABLand aberrant expression ofZfp423/ZNF423induce blast crisis of chronic myelogenous leukemia

(2009) Kazuko Miyazaki et al.   BLOOD

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation

(2009) Keikichi Takahashi et al.   HUMAN MOLECULAR GENETICS

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

From viral infection to pulmonary arterial hypertension: a role for viral proteins?

(2008) Norbert F Voelkel et al.   AIDS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension

(2008) Evangelos D. Michelakis et al.   CIRCULATION

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS

Idiopathic pulmonary fibrosis

(2008) Eric B Meltzer et al.   Orphanet Journal of Rare Diseases