Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

Aging, senescence and mitochondria: the PGC-1/ERR axis

(2020) Vincent Giguere et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Impaired Skeletal Muscle Branched-Chain Amino Acids Catabolism Contributes to Their Increased Circulating Levels in a Non-Obese Insulin-Resistant Fructose-Fed Rat Model

(2019) Jérémie David et al.   Nutrients

Branched Chain Amino Acids: Beyond Nutrition Metabolism

(2018) Cunxi Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism

(2017) María Isabel Hernández-Alvarez et al.   Scientific Reports

Deletion of the transcriptional coactivator PGC1α in skeletal muscles is associated with reduced expression of genes related to oxidative muscle function

(2016) Yukino Hatazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice

(2016) Kristoffer Svensson et al.   FASEB JOURNAL

Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease

(2016) Inmaculada Moreno-Santos et al.   Journal of Translational Medicine

Plasma metabolomic response to postmenopausal weight loss induced by different diets

(2016) Elin Chorell et al.   Metabolomics

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

(2016) Luca A. Lotta et al.   PLOS MEDICINE

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism

(2016) Carles Lerin et al.   Molecular Metabolism

Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults

(2015) Danxia Yu et al.   Metabolomics

PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle

(2014) Yukino Hatazawa et al.   PLoS One

Metabolite Profiles During Oral Glucose Challenge

(2013) Jennifer E. Ho et al.   DIABETES

Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach

(2013) C. Menni et al.   DIABETES

Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics

(2013) Fengguo Xu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

(2010) Mark A. Herman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Sensitivity of Lipid Metabolism and Insulin Signaling to Genetic Alterations in Hepatic Peroxisome Proliferator-Activated Receptor-  Coactivator-1  Expression

(2009) J. L. Estall et al.   DIABETES

Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

(2009) K. M. Huffman et al.   DIABETES CARE

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

(2008) Oded Shaham et al.   Molecular Systems Biology