BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model

Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes

(2022) Sira Karvinen et al.   Metabolites

Apoptosis-inducing factor plays a role in the pathogenesis of hepatic and renal injury during cholestasis

(2021) Vahid Ghanbarinejad et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human

(2021) Yoichi Toyokawa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets

(2020) Jinghui Heng et al.   Nutrition & Metabolism

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

(2020) Huishou Zhao et al.   DIABETES

SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19

(2020) Yijin Wang et al.   JOURNAL OF HEPATOLOGY

MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation

(2020) Jun Zheng et al.   Cell Death & Disease

Upregulation of BCL-2 by acridone derivative through gene promoter i-motif for alleviating liver damage of NAFLD/NASH

(2020) Xiaoya Li et al.   NUCLEIC ACIDS RESEARCH

PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone

(2018) Jie Li et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Branched Chain Amino Acids: Beyond Nutrition Metabolism

(2018) Cunxi Nie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Apoptosis and non-alcoholic fatty liver diseases

(2018) Tatsuo Kanda et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study

(2018) Kara Wegermann et al.   PLoS One

Role of the PI3K/AKT signalling pathway in apoptotic cell death in the cerebral cortex of streptozotocin-induced diabetic rats

(2017) Yan Meng et al.   Experimental and Therapeutic Medicine

Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress

(2016) Caifeng Xie et al.   LIFE SCIENCES

Biomarkers in Nonalcoholic Fatty Liver Disease

(2016) Manuela G Neuman et al.   Canadian Journal of Gastroenterology and Hepatology

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

(2015) Sophie M. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Inflammatory and Antinociceptive Activity of Coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae)

(2015) Alev Tosun et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis

(2014) C.P. Li et al.   GENETICS AND MOLECULAR RESEARCH

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

(2014) Fatiha Nassir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver

(2014) Rafaela Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats

(2013) Z-Q. Yu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species

(2012) D.R. Vianna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

(2012) Rohit Loomba et al.   HEPATOLOGY

Diabetes and apoptosis: lipotoxicity

(2009) Christine M. Kusminski et al.   APOPTOSIS

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Docking and quantitative structure–activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase

(2009) Julio Caballero et al.   MOLECULAR DIVERSITY

Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes

(2008) Hideaki Miyoshi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY