BCAT1 redox function maintains mitotic fidelity

The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells

(2022) James Hillier et al.   Antioxidants

A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

(2022) Dilyana Georgieva Kirova et al.   DEVELOPMENTAL CELL

A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors

(2021) Barbara Costa et al.   Cancers

Robust inference of kinase activity using functional networks

(2021) Serhan Yılmaz et al.   Nature Communications

PhosR enables processing and functional analysis of phosphoproteomic data

(2021) Hani Jieun Kim et al.   Cell Reports

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

(2021) Claudia Lennicke et al.   MOLECULAR CELL

Cell cycle control in cancer

(2021) Helen K. Matthews et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

(2020) Sharanya Sivanand et al.   CANCER CELL

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Moonlighting Functions of the Branched-Chain Aminotransferase Proteins

(2020) Myra Elizabeth Conway   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Redox priming promotes Aurora A activation during mitosis

(2020) Daniel C. Lim et al.   Science Signaling

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

(2020) Dominic P. Byrne et al.   Science Signaling

ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest

(2019) Jesse C. Patterson et al.   Cell Systems

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

(2019) Zhimin Gu et al.   Cancer Discovery

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

(2019) Yuetong Wang et al.   Cell Reports

Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP 1 and PP 2A

(2019) James Holder et al.   FEBS LETTERS

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore

(2019) Richard J. Smith et al.   Cell Reports

Covalent Aurora A regulation by the metabolic integrator coenzyme A

(2019) Yugo Tsuchiya et al.   Redox Biology

An advanced glioma cell invasion assay based on organotypic brain slice cultures

(2018) Tanja Eisemann et al.   BMC CANCER

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

(2018) Spyridon T. Pachis et al.   Open Biology

A curated resource for phosphosite-specific signature analysis

(2018) Karsten Krug et al.   MOLECULAR & CELLULAR PROTEOMICS

The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation

(2018) Simranjit Singh et al.   Scientific Reports

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

(2017) V Thewes et al.   ONCOGENE

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition

(2016) Kuan-Chung Su et al.   Cell Reports

Control of the pericentrosomal H2O2level by peroxiredoxin I is critical for mitotic progression

(2015) Jung Mi Lim et al.   JOURNAL OF CELL BIOLOGY

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Shaping up to divide: Coordinating actin and microtubule cytoskeletal remodelling during mitosis

(2014) Oscar M. Lancaster et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A

(2014) Julia Häfner et al.   Nature Communications

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

The Branched-Chain Aminotransferase Proteins: Novel Redox Chaperones for Protein Disulfide Isomerase–Implications in Alzheimer's Disease

(2013) Maya El Hindy et al.   ANTIOXIDANTS & REDOX SIGNALING

Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma

(2013) Wen Zhou et al.   Molecular Cancer

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Mps1 promotes rapid centromere accumulation of Aurora B

(2012) Maike S van der Waal et al.   EMBO REPORTS

Differential redox potential between the human cytosolic and mitochondrial branched-chain aminotransferase

(2011) Steven J. Coles et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

(2011) Robert Karisch et al.   CELL

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Cysteine-Based Redox Switches in Enzymes

(2010) Chananat Klomsiri et al.   ANTIOXIDANTS & REDOX SIGNALING

MetaboliteDetector: Comprehensive Analysis Tool for Targeted and Nontargeted GC/MS Based Metabolome Analysis

(2009) Karsten Hiller et al.   ANALYTICAL CHEMISTRY

The cell cycle is a redox cycle: Linking phase-specific targets to cell fate

(2009) William C. Burhans et al.   FREE RADICAL BIOLOGY AND MEDICINE

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

(2009) Judy Qiju Wu et al.   NATURE CELL BIOLOGY

Regulatory Control of Human Cytosolic Branched-Chain Aminotransferase by Oxidation and S-Glutathionylation and Its Interactions with Redox Sensitive Neuronal Proteins†

(2008) Myra E. Conway et al.   BIOCHEMISTRY

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis

(2008) Judith M. de Bont et al.   NEURO-ONCOLOGY