Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1

(2015) Desiree DeMille et al.   MOLECULAR BIOLOGY OF THE CELL

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

State Transitions in the TORC1 Signaling Pathway and Information Processing in Saccharomyces cerevisiae

(2014) J. E. Hughes Hallett et al.   GENETICS

Endolysosomal Membrane Trafficking Complexes Drive Nutrient-Dependent TORC1 Signaling to Control Cell Growth inSaccharomyces cerevisiae

(2014) Joanne M. Kingsbury et al.   GENETICS

l-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome

(2014) Baoshan Xu et al.   HUMAN MOLECULAR GENETICS

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

(2014) Daniele Stracka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+T Cells

(2014) Elitsa A. Ananieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling

(2014) K. A. Braun et al.   Science Signaling

Genome Wide Proteomics of ERBB2 and EGFR and Other Oncogenic Pathways in Inflammatory Breast Cancer

(2013) Emma Yue Zhang et al.   JOURNAL OF PROTEOME RESEARCH

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Genetic analysis of the metabolic pathways responsible for aroma metabolite production by Saccharomyces cerevisiae

(2012) Gustav Styger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

(2012) P. O. Ljungdahl et al.   GENETICS

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

(2012) Yun Chen et al.   METABOLIC ENGINEERING

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

(2012) Terunao Takahara et al.   MOLECULAR CELL

The TOR Complex 1 Is a Direct Target of Rho1 GTPase

(2012) Gonghong Yan et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase

(2011) Faith V. Mayer et al.   Cell Metabolism

The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation

(2011) Ruben Ghillebert et al.   FEBS Journal

Interaction between glutamate dehydrogenase (GDH) and l-leucine catabolic enzymes: Intersecting metabolic pathways

(2011) Susan M. Hutson et al.   NEUROCHEMISTRY INTERNATIONAL

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body

(2010) Eleanor J. Taylor et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

Branched-chain Amino Acid Metabolon

(2009) Mohammad Mainul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2 ) mutants is influenced by the carbon source and rapamycin

(2009) J. M. Kingsbury et al.   MICROBIOLOGY-SGM

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator

(2009) Renata Usaite et al.   Molecular Systems Biology

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue

(2008) Paul E. Minkler et al.   ANALYTICAL BIOCHEMISTRY

The Ehrlich Pathway for Fusel Alcohol Production: a Century of Research on Saccharomyces cerevisiae Metabolism

(2008) L. A. Hazelwood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

(2008) Christine T. Ferrara et al.   PLoS Genetics

Secreted 3-Isopropylmalate Methyl Ester Signals Invasive Growth during Amino Acid Starvation inSaccharomyces cerevisiae†

(2007) Darren S. Dumlao et al.   BIOCHEMISTRY

The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids

(2003) Hanna Forsberg et al.   MOLECULAR MICROBIOLOGY