The role of mtDAMPs in the trauma-induced systemic inflammatory response syndrome

Oridonin ameliorates traumatic brain injury-induced neurological damage by improving mitochondrial function and antioxidant capacity and suppressing neuroinflammation through the Nrf2 pathway

(2022) Xiao-Jing Zhao et al.   JOURNAL OF NEUROTRAUMA

ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway

(2022) Lin Cai et al.   Cell Communication and Signaling

Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury

(2022) Li Chen et al.   HEPATOLOGY

Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway

(2022) Fei Yang et al.   Journal of Integrative Neuroscience

Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)

(2022) Can Kong et al.   Molecular Medicine Reports

Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury

(2022) Hao Du et al.   Frontiers in Cellular Neuroscience

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

(2022) Yasmine Messaoud-Nacer et al.   Cell Death & Disease

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

(2022) Lauren E. Fritsch et al.   Frontiers in Molecular Neuroscience

Minimized Extracorporeal Circulation Is Associated with Reduced Plasma Levels of Free-Circulating Mitochondrial DNA Compared to Conventional Cardiopulmonary Bypass: A Secondary Analysis of an Exploratory, Prospective, Interventional Study

(2022) Thomas Zajonz et al.   Journal of Clinical Medicine

Intranasal Administration of Agomir-let-7i Improves Cognitive Function in Mice with Traumatic Brain Injury

(2022) Xuan-Cheng He et al.   Cells

Late-Onset Acute Kidney Injury is a Poor Prognostic Sign for Severe Burn Patients

(2022) Bo You et al.   Frontiers in Surgery

The Role of Neuroinflammatory Mediators in the Pathogenesis of Traumatic Brain Injury: A Narrative Review

(2022) Züleyha Doğanyiğit et al.   ACS Chemical Neuroscience

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3/NF-κB and inflammasome activation

(2022) Wei Ding et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STING mediates neuroinflammatory response by activating NLRP3 ‐related pyroptosis in severe traumatic brain injury

(2022) Li‐Min Zhang et al.   JOURNAL OF NEUROCHEMISTRY

SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease

(2022) Yuexin Zhu et al.   Oxidative Medicine and Cellular Longevity

RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia–Reperfusion

(2022) Yansheng Feng et al.   Cells

Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma

(2022) Ana Belen Lopez-Rodriguez et al.   Pharmaceutics

Low-intensity focused ultrasound attenuates early traumatic brain injury by OX-A/NF-κB/NLRP3 signaling pathway

(2022) Lianghua Huang et al.   Aging-US

Amplified Gliosis and Interferon-Associated Inflammation in the Aging Brain Following Diffuse Traumatic Brain Injury

(2022) Lynde M Wangler et al.   JOURNAL OF NEUROSCIENCE

Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax

(2022) Jingyao Li et al.   KIDNEY INTERNATIONAL

Mitochondrial antioxidant SkQ1 decreases inflammation following hemorrhagic shock by protecting myocardial mitochondria

(2022) Bo Jia et al.   Frontiers in Physiology

Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury

(2021) Mark Hepokoski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Mitochondria-Derived Danger Signals Released after Injury in Systemic Inflammation and Sepsis

(2021) Kiyoshi Itagaki et al.   ANTIOXIDANTS & REDOX SIGNALING

The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat

(2021) Paul B. Comish et al.   BURNS

Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation

(2021) Weiwei Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY

ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome

(2021) Xiao-yan Wu et al.   ACTA PHARMACOLOGICA SINICA

NLRP3 inflammasome activation and cell death

(2021) Yi Huang et al.   Cellular & Molecular Immunology

Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis

(2021) Carlos Torre‐Minguela et al.   FASEB JOURNAL

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

Serum Caspase-1 as an Independent Prognostic Factor in Traumatic Brain Injured Patients

(2021) Jon Pérez-Bárcena et al.   Neurocritical Care

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

(2021) Qinjie Liu et al.   Cell Death & Disease

Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice

(2021) James P. Barrett et al.   Frontiers in Immunology

Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits

(2021) Mathieu Blot et al.   ANESTHESIOLOGY

Anthocyanin Extract from Purple Sweet Potato Exacerbate Mitophagy to Ameliorate Pyroptosis in Klebsiella pneumoniae Infection

(2021) Guokai Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel role of BK potassium channel activity in preventing the development of kidney fibrosis

(2021) Yinhang Wang et al.   KIDNEY INTERNATIONAL

The Effect of MaxiK Channel on Regulating the Activation of NLRP3 Inflammasome in Rats of Blast-induced Traumatic Brain Injury

(2021) Jie Ma et al.   NEUROSCIENCE

Mitochondrial DNA: cellular genotoxic stress sentinel

(2021) Zheng Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

(2021) Joschka Willemsen et al.   Cell Reports

Tanreqing Inhibits LPS-Induced Acute Lung Injury In Vivo and In Vitro Through Downregulating STING Signaling Pathway

(2021) Yu-Qiong He et al.   Frontiers in Pharmacology

A membrane-tethering pepducin derived from formyl peptide receptor 3 shows strong therapeutic effects against sepsis

(2020) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MitoQ protects against liver injury induced by severe burn plus delayed resuscitation by suppressing the mtDNA-NLRP3 axis

(2020) Yin Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation

(2020) Haiyan Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

(2020) William T. O’Brien et al.   Journal of Neuroinflammation

Mitoprotection prevents increased synovial fluid mitochondrial DNA concentrations after articular injury

(2020) L.A. Seewald et al.   OSTEOARTHRITIS AND CARTILAGE

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

(2020) Shufen Li et al.   Cell Reports

Prognostic value of plasma mitochondrial DNA in acute respiratory distress syndrome (ARDS): a single-center observational study

(2020) Lili Huang et al.   Journal of Thoracic Disease

Toll-like receptor 9 and the inflammatory response to surgical trauma and cardiopulmonary bypass

(2020) Hatam Naase et al.   Journal of Cardiothoracic Surgery

Corticosteroids alleviate lipopolysaccharide‐induced inflammation and lung injury via inhibiting NLRP3‐inflammasome activation

(2020) Jia‐Wei Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study

(2020) Finosh G Thankam et al.   Translational Research

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

(2020) Ren Jing et al.   Frontiers in Cell and Developmental Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA

(2020) Meng Zhao et al.   ACS Nano

MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

(2020) Johnatas Dutra Silva et al.   EUROPEAN RESPIRATORY JOURNAL

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

(2019) Katherine C. Barnett et al.   CELL

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Murine Model: Protective Effect of Cyclosporine-A

(2019) Ruiqi Liu et al.   Journal of Burn Care & Research

Mitochondrial DNA in liver inflammation and oxidative stress

(2019) Xufei Zhang et al.   LIFE SCIENCES

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside

(2019) Sicheng Li et al.   Oxidative Medicine and Cellular Longevity

Cytochrome c can be released into extracellular space and modulate functions of human astrocytes in a toll-like receptor 4-dependent manner

(2019) Tyler J. Wenzel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular release of ATP promotes systemic inflammation during acute pancreatitis

(2019) Ajay Dixit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

(2019) Hilary E. Faust et al.   CHEST

Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma

(2019) Kiyoshi Itagaki et al.   CRITICAL CARE MEDICINE

Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS

(2019) Serge Grazioli et al.   PLoS One

Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB

(2019) Guannan Wu et al.   Journal of Thoracic Disease

The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

(2018) Kabilan Thurairajah et al.   European Journal of Trauma and Emergency Surgery

Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

(2018) Nicola Sandler et al.   Heart Lung and Circulation

Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM)

(2018) Stephanie M. Schindler et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction

(2018) Qiongyuan Hu et al.   Scientific Reports

Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

(2018) Andrew Aswani et al.   Frontiers in Immunology

Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient

(2018) Mickael Vourc’h et al.   Frontiers in Immunology

High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

(2018) Jin-Yuan Lin et al.   Frontiers in Immunology

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF‐κB activity

(2018) Carlos A. Puyo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

(2018) Amar Abdullah et al.   Journal of Neuroinflammation

Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Cyclosporine-A via Suppression of Mitochondrial DNA

(2018) Zhenghua Xiao et al.   MEDICAL SCIENCE MONITOR

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle

(2018) Harumasa Nakazawa et al.   FEBS Open Bio

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

(2017) Patricia A. Martinez-Quinones et al.   Journal of Trauma and Acute Care Surgery

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

(2017) Jessica S. Wallisch et al.   Neurocritical Care

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome

(2017) David A Dorward et al.   THORAX

Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma

(2017) Qiongyuan Hu et al.   Surgical Infections

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

(2017) Patricia A. Martinez-Quinones et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation

(2016) Camilla Ferreira Wenceslau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome

(2015) Camilla Ferreira Wenceslau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

(2015) A. Kru ger et al.   EMBO REPORTS

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

(2015) Jon Hazeldine et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Cerebrospinal Fluid Mitochondrial DNA

(2014) Thomas D. Walko et al.   SHOCK

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

(2013) Shiqin Sun et al.   PLoS One

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

(2013) Xiaoling Gu et al.   PLoS One

Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury

(2013) Orr Hadass et al.   PLoS One

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Trauma alarmins as activators of damage-induced inflammation

(2011) J. Manson et al.   BRITISH JOURNAL OF SURGERY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Mitochondrial Damage Associated Molecular Patterns From Femoral Reamings Activate Neutrophils Through Formyl Peptide Receptors and P44/42 MAP Kinase

(2010) Carl J Hauser et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS