The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

Dissecting the biochemical architecture and morphological release pathways of the human platelet extracellular vesiculome

(2018) Silvia H. De Paoli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

(2018) Nicola Sandler et al.   Heart Lung and Circulation

Clinical implications and pathological associations of circulating mitochondrial DNA

(2017) Zsolt J Balogh   Frontiers in Bioscience-Landmark

Plasma mitochondrial DNA levels were independently associated with lung injury in elderly hip fracture patients

(2017) Jian-zheng Zhang et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

(2017) Patricia A. Martinez-Quinones et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial DNA-induced inflammatory damage contributes to myocardial ischemia reperfusion injury in rats: Cardioprotective role of epigallocatechin

(2017) Chao-Yi Qin et al.   Molecular Medicine Reports

Exogenous administration of mitochondrial DNA promotes ischemia reperfusion injury via TLR9-p38 MAPK pathway

(2017) Liang Xie et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The mitochondrial dynamics in cancer and immune-surveillance

(2017) Luca Simula et al.   SEMINARS IN CANCER BIOLOGY

Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage

(2017) Sherry H.-Y. Chou et al.   STROKE

Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma

(2017) Qiongyuan Hu et al.   Surgical Infections

Circulating cell-free DNA content as blood based biomarker in endometrial cancer

(2017) Lucia Cicchillitti et al.   Oncotarget

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

(2017) Patricia A. Martinez-Quinones et al.   Journal of Trauma and Acute Care Surgery

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

(2017) Heather M. Wilkins et al.   Frontiers in Immunology

NETosis markers: Quest for specific, objective, and quantitative markers

(2016) Sakiko Masuda et al.   CLINICA CHIMICA ACTA

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microparticle and mitochondrial release during extended storage of different types of platelet concentrates

(2016) Geneviève Marcoux et al.   PLATELETS

Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection

(2016) Ling Li et al.   Scientific Reports

Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release

(2016) Guang Xin et al.   Scientific Reports

Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion

(2015) Xi-Ming Yang et al.   BASIC RESEARCH IN CARDIOLOGY

Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9–p38 MAPK pathway

(2015) Xiaoling Gu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Role of high shear rate in thrombosis

(2015) Lauren D.C. Casa et al.   JOURNAL OF VASCULAR SURGERY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

(2015) Anne-Claire Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Cell necrosis–independent sustained mitochondrial and nuclear DNA release following trauma surgery

(2015) Daniel J. McIlroy et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery

(2014) Daniel J. McIlroy et al.   JOURNAL OF CRITICAL CARE

High-throughput sequencing in mitochondrial DNA research

(2014) Fei Ye et al.   MITOCHONDRION

Direct Quantification of Cell-Free, Circulating DNA from Unpurified Plasma

(2014) Sarah Breitbach et al.   PLoS One

Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

(2014) A Maeda et al.   Cell Death & Disease

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status

(2013) Satoshi Yamanouchi et al.   JOURNAL OF CRITICAL CARE

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

(2013) Xiaoling Gu et al.   PLoS One

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

(2012) Wei Meng et al.   MEDIATORS OF INFLAMMATION

Trauma alarmins as activators of damage-induced inflammation

(2011) J. Manson et al.   BRITISH JOURNAL OF SURGERY

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Damage Associated Molecular Patterns From Femoral Reamings Activate Neutrophils Through Formyl Peptide Receptors and P44/42 MAP Kinase

(2010) Carl J Hauser et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

NEUTROPHIL-DERIVED CIRCULATING FREE DNA (cf-DNA/NETs)

(2008) Stefan Margraf et al.   SHOCK