The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

Inflammasome proteins as biomarkers of traumatic brain injury

(2019) Nadine Kerr et al.   PLoS One

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

(2019) Carla M. Startin et al.   Alzheimers Research & Therapy

NOD-like receptor protein 3 inflammasome drives postoperative mechanical pain in a sex-dependent manner

(2019) Ashley M. Cowie et al.   PAIN

Mild closed head injury in conscious rats causes transient neurobehavioral and glial disturbances: A novel experimental model of concussion

(2019) Louise Pham et al.   JOURNAL OF NEUROTRAUMA

Sex differences in traumatic brain injury: What we know and what we should know

(2019) Raeesa Gupte et al.   JOURNAL OF NEUROTRAUMA

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I‐CLINDE single photon emission computed tomography study

(2019) S. E. Ebert et al.   EUROPEAN JOURNAL OF NEUROLOGY

Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases

(2019) Nina Boxberger et al.   JOURNAL OF IMMUNOLOGY

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Synergistic Role of Oxidative Stress and Blood-Brain Barrier Permeability as Injury Mechanisms in the Acute Pathophysiology of Blast-induced Neurotrauma

(2019) Matthew Kuriakose et al.   Scientific Reports

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

(2019) Vandana Deora et al.   GLIA

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

(2019) Si Yun Ng et al.   Frontiers in Cellular Neuroscience

The need to incorporate aged animals into the preclinical modeling of neurological conditions

(2019) Mujun Sun et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Principles of inflammasome priming and inhibition: Implications for psychiatric disorders

(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

(2018) Jacob Fulp et al.   JOURNAL OF MEDICINAL CHEMISTRY

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

(2018) Saifudeen Ismael et al.   JOURNAL OF NEUROTRAUMA

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke

(2018) Saifudeen Ismael et al.   Scientific Reports

Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention

(2018) Li Zhang et al.   Frontiers in Molecular Neuroscience

Inflammasome Proteins As Biomarkers of Multiple Sclerosis

(2018) Robert W. Keane et al.   Frontiers in Neurology

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study

(2018) Thomas J. McColl et al.   Frontiers in Neurology

The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury

(2018) Kai-Ying Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

(2018) Bin Zheng et al.   BIOSCIENCE REPORTS

Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs

(2018) Yifei Wang et al.   JOURNAL OF IMMUNOLOGY

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming

(2018) Jack P. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke

(2018) Nadine Kerr et al.   Frontiers in Molecular Neuroscience

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury

(2017) Chao Lin et al.   EXPERIMENTAL NEUROLOGY

Sexual dimorphism in the inflammatory response to traumatic brain injury

(2017) Sonia Villapol et al.   GLIA

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

(2017) Jessica S. Wallisch et al.   Neurocritical Care

Traumatic brain injury in India: A big problem in need of data

(2017) AndrewI R Maas   NEUROLOGY INDIA

Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats

(2017) Xiaofeng Liu et al.   Purinergic Signalling

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Microglial Activation in Traumatic Brain Injury

(2017) Cornelius K. Donat et al.   Frontiers in Aging Neuroscience

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

(2017) Natasha Irrera et al.   Frontiers in Pharmacology

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

(2016) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Traumatic brain injury: It is all about definition

(2016) B. Savitsky et al.   BRAIN INJURY

Knowing What We Don’t Know: Long-Term Psychiatric Outcomes following Adult Concussion in Sports

(2016) Nathan W. B. Finkbeiner et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast-Induced Traumatic Brain Injury in Rats

(2016) Jie Ma et al.   INFLAMMATION

Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis

(2016) Christian LoBue et al.   JOURNAL OF ALZHEIMERS DISEASE

Telmisartan reduced cerebral edema by inhibiting NLRP3 inflammasome in mice with cold brain injury

(2016) Xin Wei et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol

(2016) Roshni Thakkar et al.   Oxidative Medicine and Cellular Longevity

Regulating effect of activated NF-κB on edema induced by traumatic brain injury of rats

(2016) Zi-Ran Wang et al.   Asian Pacific Journal of Tropical Medicine

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

(2016) Jonathan D. Cherry et al.   Acta Neuropathologica Communications

Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples

(2015) Danlu Wu et al.   ANALYST

Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit

(2015) Islam N. Mohamed et al.   ANTIOXIDANTS & REDOX SIGNALING

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

(2015) Alasdair Timothy Llewelyn Rathbone et al.   BRAIN BEHAVIOR AND IMMUNITY

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology

(2015) G. Brown et al.   CURRENT MOLECULAR MEDICINE

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study

(2015) Jennifer M. Coughlin et al.   NEUROBIOLOGY OF DISEASE

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional Neurodegeneration and Gliosis Are Amplified by Mild Traumatic Brain Injury Repeated at 24-Hour Intervals

(2014) Amanda N. Bolton et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROTRAUMA

Interactions of Oxidative Stress and Neurovascular Inflammation in the Pathogenesis of Traumatic Brain Injury

(2014) P. M. Abdul-Muneer et al.   MOLECULAR NEUROBIOLOGY

Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury

(2014) Dhananjay R Namjoshi et al.   Molecular Neurodegeneration

Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury

(2014) Zachary M. Weil et al.   NEUROBIOLOGY OF DISEASE

The pathophysiology of traumatic brain injury at a glance

(2013) M. Prins et al.   Disease Models & Mechanisms

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Inflammatory Consequences in a Rodent Model of Mild Traumatic Brain Injury

(2013) J. Regino Perez-Polo et al.   JOURNAL OF NEUROTRAUMA

Pharmacotherapy of Traumatic Brain Injury: State of the Science and the Road Forward: Report of the Department of Defense Neurotrauma Pharmacology Workgroup

(2013) Ramon Diaz-Arrastia et al.   JOURNAL OF NEUROTRAUMA

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Increased Levels of Serum IL-18 Are Associated with the Long-Term Outcome of Severe Traumatic Brain Injury

(2013) Antonio Ciaramella et al.   NEUROIMMUNOMODULATION

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

Repeated Mild Lateral Fluid Percussion Brain Injury in the Rat Causes Cumulative Long-Term Behavioral Impairments, Neuroinflammation, and Cortical Loss in an Animal Model of Repeated Concussion

(2011) Sandy R. Shultz et al.   JOURNAL OF NEUROTRAUMA

MicroRNAs in Development and Disease

(2011) Danish Sayed et al.   PHYSIOLOGICAL REVIEWS

Position Statement: Definition of Traumatic Brain Injury

(2010) David K. Menon et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY