Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury

Repetitive mild closed head injury in adolescent mice is associated with impaired proteostasis, neuroinflammation, and tauopathy

(2022) Limin Wu et al.   JOURNAL OF NEUROSCIENCE

TLR4‐pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury

(2021) Juliana M. Rosa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gasdermin D in pyroptosis

(2021) Brandon Burdette et al.   Acta Pharmaceutica Sinica B

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

(2021) Stella Chin-Shaw Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High glutamate concentration reverses the inhibitory effect of microglial adenosine 2A receptor on NLRP3 inflammasome assembly and activation

(2021) Hao Du et al.   NEUROSCIENCE LETTERS

A long way to go: caspase inhibitors in clinical use

(2021) Shanel Dhani et al.   Cell Death & Disease

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

Expression of a short antibody heavy chain peptide effectively antagonizes adenosine 2A receptor in vitro and in vivo

(2020) Zhuo-Hang Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

(2020) William T. O’Brien et al.   Journal of Neuroinflammation

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice

(2020) Zhezhe Sun et al.   Oxidative Medicine and Cellular Longevity

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson’s Disease

(2020) Wenjuan Rui et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats

(2020) Xiao Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

(2020) Luting Poh et al.   MOLECULAR PSYCHIATRY

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

(2020) Kankai Wang et al.   Frontiers in Neurology

Traumatic brain injury in China

(2019) Ji-Yao Jiang et al.   LANCET NEUROLOGY

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

(2019) Sheng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury

(2018) Xu-Jia Zeng et al.   Cell Death & Disease

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

(2018) Maria Cristina Morganti-Kossmann et al.   ACTA NEUROPATHOLOGICA

Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia

(2017) Zheng Fan et al.   Journal of Neuroinflammation

The chronic and evolving neurological consequences of traumatic brain injury

(2017) Lindsay Wilson et al.   LANCET NEUROLOGY

Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children

(2017) Jessica S. Wallisch et al.   Neurocritical Care

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

(2017) Natasha Irrera et al.   Frontiers in Pharmacology

Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury

(2016) Thomas Brickler et al.   MEDIATORS OF INFLAMMATION

Neuroprotective effects of resveratrol against traumatic brain injury in rats: Involvement of synaptic proteins and neuronal autophagy

(2016) YAN FENG et al.   Molecular Medicine Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model

(2007) W. Li et al.   NEUROSCIENCE