Role of Mitochondria-Derived Danger Signals Released after Injury in Systemic Inflammation and Sepsis

The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9

(2021) Yao Tong et al.   Cell Death & Disease

Endothelial Responses in Sepsis

(2020) Jérémie Joffre et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Blood Levels of Free-Circulating Mitochondrial DNA in Septic Shock and Postsurgical Systemic Inflammation and Its Influence on Coagulation: A Secondary Analysis of a Prospective Observational Study

(2020) Emmanuel Schneck et al.   Journal of Clinical Medicine

MONOCYTE EXOCYTOSIS OF MITOCHONDRIAL DAMPS IN SEPSIS SUPPRESSES NEUTROPHIL CHEMOTAXIS

(2020) Barbora Konecna et al.   Journal of Trauma and Acute Care Surgery

Concepts of GPCR ‐controlled navigation in the immune system

(2019) Tim Lämmermann et al.   IMMUNOLOGICAL REVIEWS

The formyl peptide fMLF primes platelet activation and augments thrombus formation

(2019) Maryam F. Salamah et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction

(2019) Beñat Mallavia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma

(2019) Kiyoshi Itagaki et al.   CRITICAL CARE MEDICINE

The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

(2018) Kabilan Thurairajah et al.   European Journal of Trauma and Emergency Surgery

Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

(2018) Nicola Sandler et al.   Heart Lung and Circulation

A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS

(2018) Elzbieta Kaczmarek et al.   Journal of Trauma and Acute Care Surgery

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS

(2018) Elzbieta Kaczmarek et al.   Journal of Trauma and Acute Care Surgery

Establishing position papers by the WSES

(2018) Miklosh Bala et al.   World Journal of Emergency Surgery

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer

(2018) Kelly L. Singel et al.   BRITISH JOURNAL OF CANCER

Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction

(2017) Fatemeh Fattahi et al.   FASEB JOURNAL

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns

(2017) Kiyoshi Itagaki et al.   Journal of Trauma and Acute Care Surgery

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome

(2017) David A Dorward et al.   THORAX

Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma

(2017) Qiongyuan Hu et al.   Surgical Infections

Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns

(2017) Kiyoshi Itagaki et al.   Journal of Trauma and Acute Care Surgery

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress

(2016) Walid Mohamed et al.   BMC MICROBIOLOGY

Increased risk for secondary infections in trauma patients with viral reactivation

(2016) Rebecca M. Koch et al.   INTENSIVE CARE MEDICINE

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice

(2016) Alexander O. Krogmann et al.   PLoS One

Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation

(2016) Camilla Ferreira Wenceslau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Formyl Peptide Receptor Activation Elicits Endothelial Cell Contraction and Vascular Leakage

(2016) Camilla F. Wenceslau et al.   Frontiers in Immunology

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

(2015) Balázs Csóka et al.   FASEB JOURNAL

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Vascular endothelial cell Toll-like receptor pathways in sepsis

(2015) Samira Khakpour et al.   Innate Immunity

Neutrophil extracellular traps in patients with sepsis

(2015) Masamitsu Hashiba et al.   JOURNAL OF SURGICAL RESEARCH

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Endogenous Hydrogen Sulfide Regulates Inflammatory Response by Activating the ERK Pathway in Polymicrobial Sepsis

(2014) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

FPR2/ALXR Agonists and the Resolution of Inflammation

(2014) Olivier Corminboeuf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutrophil Extracellular Traps in Sepsis

(2014) Gabriela Camicia et al.   SHOCK

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

(2013) Jon D. Simmons et al.   ANNALS OF SURGERY

Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2

(2013) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus

(2013) Diana Mader et al.   BMC MICROBIOLOGY

Structural Determinants for the Interaction of Formyl Peptide Receptor 2 with Peptide Ligands

(2013) Hui-Qiong He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: Time course and the association with clinical status

(2013) Satoshi Yamanouchi et al.   JOURNAL OF CRITICAL CARE

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial-derived N-formyl peptides: Novel links between trauma, vascular collapse and sepsis

(2013) C.F. Wenceslau et al.   MEDICAL HYPOTHESES

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

(2013) Shiqin Sun et al.   PLoS One

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

(2013) Xiaoling Gu et al.   PLoS One

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers of Endothelial Cell Activation in Early Sepsis

(2013) Simon Skibsted et al.   SHOCK

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antibiotic strategies in severe nosocomial sepsis

(2012) Sarah Heenen et al.   CRITICAL CARE MEDICINE

Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils

(2012) Ravi S. Keshari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

A novel role for matrix metalloproteinase-8 in sepsis*

(2011) Patrick D. Solan et al.   CRITICAL CARE MEDICINE

Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9

(2011) Ana M. Avalos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

N-Formyl Peptide Receptor 3 (FPR3) Departs from the Homologous FPR2/ALX Receptor with Regard to the Major Processes Governing Chemoattractant Receptor Regulation, Expression at the Cell Surface, and Phosphorylation

(2011) Marie-Josèphe Rabiet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines

(2011) Anneli Lauhio et al.   PHARMACOLOGICAL RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Matrix Metalloproteinases as Drug Targets in Infections Caused by Gram-Negative Bacteria and in Septic Shock

(2009) I. Vanlaere et al.   CLINICAL MICROBIOLOGY REVIEWS

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

NF-κB and P38 MAPK Inhibition Improve Survival in Endotoxin Shock and in a Cecal Ligation and Puncture Model of Sepsis in Combination With Antibiotic Therapy

(2008) Adrian W. O'Sullivan et al.   JOURNAL OF SURGICAL RESEARCH

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE