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Title
NLRP3 inflammasome activation and cell death
Authors
Keywords
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Journal
Cellular & Molecular Immunology
Volume 18, Issue 9, Pages 2114-2127
Publisher
Springer Science and Business Media LLC
Online
2021-07-28
DOI
10.1038/s41423-021-00740-6
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Note: Only part of the references are listed.- Disulfiram: a novel repurposed drug for cancer therapy
- (2021) Chen Lu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2021) Xuejun Jiang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- RIPK3 Activates MLKL-Mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection
- (2021) Hua-Rong Huang et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Channelling inflammation: gasdermins in physiology and disease
- (2021) Xing Liu et al. NATURE REVIEWS DRUG DISCOVERY
- ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation
- (2021) Tianli Zhang et al. Redox Biology
- Ferroptosis and its potential as a therapeutic target
- (2021) Hanshu Yuan et al. BIOCHEMICAL PHARMACOLOGY
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
- (2020) Min Zheng et al. CELL
- Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation
- (2020) Wenmin Deng et al. FREE RADICAL BIOLOGY AND MEDICINE
- Gasdermin E suppresses tumour growth by activating anti-tumour immunity
- (2020) Zhibin Zhang et al. NATURE
- A bioorthogonal system reveals antitumour immune function of pyroptosis
- (2020) Qinyang Wang et al. NATURE
- FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
- (2020) Jun Jacob Hu et al. NATURE IMMUNOLOGY
- Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
- (2020) Zhiwei Zhou et al. SCIENCE
- SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation
- (2020) Shufen Li et al. Cell Reports
- RIPK3 blockade attenuates kidney fibrosis in a folic acid model of renal injury
- (2020) Ying Shi et al. FASEB JOURNAL
- The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
- (2020) Min Zheng et al. IMMUNOLOGICAL REVIEWS
- Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
- (2020) Min Zheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RIP-roaring inflammation: RIPK1 and RIPK3 driven NLRP3 inflammasome activation and autoinflammatory disease
- (2020) Mary Speir et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
- (2020) Balaji Banoth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
- (2019) Javier Garcia-Bermudez et al. NATURE
- Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly
- (2019) Kaiwen W Chen et al. EMBO JOURNAL
- The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
- (2019) Nathan Kelley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release
- (2019) Maryam Rashidi et al. JOURNAL OF IMMUNOLOGY
- Role of NLRP3 inflammasome in inflammatory bowel diseases
- (2019) Evanthia Tourkochristou et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2
- (2019) Ting Liu et al. Frontiers in Immunology
- Necroptosis in the Pathophysiology of Disease
- (2019) Mitri K. Khoury et al. AMERICAN JOURNAL OF PATHOLOGY
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)
- (2019) R. K. Subbarao Malireddi et al. Frontiers in Cellular and Infection Microbiology
- ApoC3: an ‘alarmin’ triggering sterile inflammation
- (2019) Tao Gong et al. NATURE IMMUNOLOGY
- Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation
- (2019) Stephen Zewinger et al. NATURE IMMUNOLOGY
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
- (2018) Rui Kang et al. Cell Host & Microbe
- Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses
- (2018) Emilie Seydoux et al. JOURNAL OF IMMUNOLOGY
- The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory
- (2018) Moritz M. Gaidt et al. JOURNAL OF MOLECULAR BIOLOGY
- Necroptosis: a regulated inflammatory mode of cell death
- (2018) Yogesh K. Dhuriya et al. Journal of Neuroinflammation
- Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress
- (2018) Min Guo et al. Frontiers in Molecular Neuroscience
- Cryo-EM structure of the gasdermin A3 membrane pore
- (2018) Jianbin Ruan et al. NATURE
- Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production
- (2018) Hong-Su Park et al. Viruses-Basel
- NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction
- (2018) Qian Lei et al. MEDICAL SCIENCE MONITOR
- Pyroptosis versus necroptosis: similarities, differences, and crosstalk
- (2018) Daniel Frank et al. CELL DEATH AND DIFFERENTIATION
- PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
- (2018) Jueqi Chen et al. NATURE
- Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
- (2018) Joseph Sarhan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
- (2018) Pontus Orning et al. SCIENCE
- ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
- (2018) Sebastian Rühl et al. SCIENCE
- The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
- (2018) James E. Vince et al. Cell Reports
- BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages
- (2018) Dhruv Chauhan et al. Cell Reports
- RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage
- (2017) Keren Zhou et al. EXPERIMENTAL NEUROLOGY
- The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome
- (2017) Raquel Domingo-Fernández et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
- (2017) Kimberley D. Gutierrez et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling–Induced Nontranscriptional Priming of the NLRP3 Inflammasome
- (2017) Yue Xing et al. JOURNAL OF IMMUNOLOGY
- NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
- (2017) Nan Song et al. MOLECULAR CELL
- Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
- (2017) Yupeng Wang et al. NATURE
- Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
- (2017) Kinlin L. Chao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
- (2017) Stephanie A. Conos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
- (2017) Jianjin Shi et al. TRENDS IN BIOCHEMICAL SCIENCES
- Gasdermins: Effectors of Pyroptosis
- (2017) Stephen B. Kovacs et al. TRENDS IN CELL BIOLOGY
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- (2017) Chong-Shan Shi et al. PLoS One
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- (2016) Si Ming Man et al. CELL
- DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
- (2016) Roshan J. Thapa et al. Cell Host & Microbe
- An outline of necrosome triggers
- (2016) Tom Vanden Berghe et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The intersection of cell death and inflammasome activation
- (2016) James E. Vince et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- (2016) Lorenzo Sborgi et al. EMBO JOURNAL
- Human Monocytes Engage an Alternative Inflammasome Pathway
- (2016) Moritz M. Gaidt et al. IMMUNITY
- Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
- (2016) Brooke A. Napier et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice
- (2016) Aiyun Li et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Regulated necrosis: disease relevance and therapeutic opportunities
- (2016) Marcus Conrad et al. NATURE REVIEWS DRUG DISCOVERY
- GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
- (2016) Robin A. Aglietti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
- (2016) Ivan Zanoni et al. SCIENCE
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
- (2016) Xixi Zhang et al. Cell Reports
- Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis
- (2016) Wei Lu et al. PLoS One
- Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
- (2015) D A Rodriguez et al. CELL DEATH AND DIFFERENTIATION
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux
- (2015) Sebastian Rühl et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
- (2015) Christina Antonopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- InternalizedCryptococcus neoformansActivates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes
- (2015) Mingkuan Chen et al. JOURNAL OF IMMUNOLOGY
- The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages
- (2015) Kenta Moriwaki et al. JOURNAL OF IMMUNOLOGY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Live to die another way: modes of programmed cell death and the signals emanating from dying cells
- (2015) Yaron Fuchs et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
- (2015) Cierra N. Casson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
- (2015) Kate E. Lawlor et al. Nature Communications
- Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage
- (2015) Kipyegon Kitur et al. PLoS Pathogens
- NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
- (2015) Amna Abderrazak et al. Redox Biology
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
- (2014) L Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
- (2014) R. Allam et al. EMBO REPORTS
- Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ
- (2014) Anthony L. Desbien et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
- (2014) P. Gurung et al. JOURNAL OF IMMUNOLOGY
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
- (2014) Etienne Meunier et al. NATURE
- RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
- (2014) Xiaqiong Wang et al. NATURE IMMUNOLOGY
- Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis
- (2014) S. M. Kallenberger et al. Science Signaling
- Necroptosis induced by RIPK3 requires MLKL but not Drp1
- (2014) D M Moujalled et al. Cell Death & Disease
- XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
- (2014) Monica Yabal et al. Cell Reports
- Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
- (2013) Amarjargal Dashdorj et al. BMC Medicine
- Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
- (2013) Y-H Wu et al. CELL DEATH AND DIFFERENTIATION
- RIP3: a molecular switch for necrosis and inflammation
- (2013) K. Moriwaki et al. GENES & DEVELOPMENT
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
- (2013) William J. Kaiser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
- (2013) Peter E. Czabotar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation
- (2013) K.-M. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways
- (2012) Zhigao Wang et al. CELL
- DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA
- (2012) Jason W. Upton et al. Cell Host & Microbe
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- (2012) James E. Vince et al. IMMUNITY
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
- (2012) Tae-Bong Kang et al. IMMUNITY
- Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
- (2012) Bénédicte F. Py et al. MOLECULAR CELL
- Critical role for calcium mobilization in activation of the NLRP3 inflammasome
- (2012) T. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
- (2012) J. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Programmed Cell Death in Animal Development and Disease
- (2011) Yaron Fuchs et al. CELL
- Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome
- (2011) Katherine Labbé et al. IMMUNITY
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
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- (2010) Mohamed Lamkanfi et al. Cell Host & Microbe
- Sodium Overload and Water Influx Activate the NALP3 Inflammasome
- (2010) Christine Schorn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inducible Dimerization and Inducible Cleavage Reveal a Requirement for Both Processes in Caspase-8 Activation
- (2010) Andrew Oberst et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A role for mitochondria in NLRP3 inflammasome activation
- (2010) Rongbin Zhou et al. NATURE
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- (2010) Peter Duewell et al. NATURE
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages
- (2010) XuZhu Lin et al. Science China-Life Sciences
- Cutting Edge: TNF- Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
- (2009) L. Franchi et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
- (2009) F. G. Bauernfeind et al. JOURNAL OF IMMUNOLOGY
- Major cell death pathways at a glance
- (2009) Linde Duprez et al. MICROBES AND INFECTION
- Pyroptosis: host cell death and inflammation
- (2009) Tessa Bergsbaken et al. NATURE REVIEWS MICROBIOLOGY
- Physiology of Cell Volume Regulation in Vertebrates
- (2009) Else K. Hoffmann et al. PHYSIOLOGICAL REVIEWS
- Differential requirement for the activation of the inflammasome for processing and release of IL-1 in monocytes and macrophages
- (2008) M. G. Netea et al. BLOOD
- Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
- (2008) Jonathan Maelfait et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Apoptosis: controlled demolition at the cellular level
- (2007) Rebecca C. Taylor et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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