Chemistry and electrochemistry of CeO₂-based interlayers: Prolonging the lifetime of solid oxide fuel and electrolysis cells

Greco-2: A randomized, phase 2 study of stereotactic body radiation therapy (SBRT) in combination with rucosopasem (GC4711) in the treatment of locally advanced or borderline resectable nonmetastatic pancreatic cancer.

(2023) Todd Anthony Aguilera et al.   JOURNAL OF CLINICAL ONCOLOGY

CJ2: A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane

(2023) Renming Fan et al.   Journal of Medicinal Chemistry

Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug

(2023) Olga O. Krasnovskaya et al.   ACS Applied Materials & Interfaces

Dual–target platinum(IV) complexes reverse cisplatin resistance in triple negative breast via inhibiting poly(ADP–ribose) polymerase (PARP–1) and enhancing DNA damage

(2023) Rui Li et al.   BIOORGANIC CHEMISTRY

New Titanocene (IV) Dicarboxylates with Potential Cytotoxicity: Synthesis, Structure, Stability and Electrochemistry

(2023) Dmitry A. Guk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Indole–Chalcone Derivative-Ligated Platinum(IV) Prodrugs Attenuate Cisplatin Resistance in Lung Cancer through ROS/ER Stress and Mitochondrial Dysfunction

(2023) Zhikun Liu et al.   Journal of Medicinal Chemistry

Development of Clioquinol Platinum(IV) Conjugates as Autophagy-Targeted Antimetastatic Agents

(2023) Ming Zhang et al.   Journal of Medicinal Chemistry

Oxali(IV)Fluors: Fluorescence Responsive Oxaliplatin(IV) Complexes Identify a Hypoxia-Dependent Reduction in Cancer Cells

(2023) Marie H. C. Boulet et al.   Journal of the American Chemical Society

Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

(2023) Zhiqin Deng et al.   Nature Chemistry

An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy

(2023) Gongyuan Liu et al.   Science Advances

Albumin-Bound Paclitaxel: Worthy of Further Study in Sarcomas

(2022) Zhichao Tian et al.   Frontiers in Oncology

BRD4‐IRF1 axis regulates chemoradiotherapy‐induced PD‐L1 expression and immune evasion in non‐small cell lung cancer

(2022) Jian Wang et al.   Clinical and Translational Medicine

One- and Two-Photon Activated Release of Oxaliplatin from a Pt(IV)-Functionalized Poly(phenylene ethynylene)

(2022) Han Sun et al.   ACS Applied Materials & Interfaces

In Vitro/In Vivo Electrochemical Detection of Pt(II) Species

(2022) Alexander N. Vaneev et al.   ANALYTICAL CHEMISTRY

Platinum(IV) Prodrugs with Cancer Stem Cell Inhibitory Effects on Lung Cancer for Overcoming Drug Resistance

(2022) Xinyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Noninvasive and Spatiotemporal Control of DNAzyme-Based Imaging of Metal Ions In Vivo Using High-Intensity Focused Ultrasound

(2022) Xiaojing Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity

(2022) Aleen Khoury et al.   Pharmaceutics

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

(2022) Philipp Fronik et al.   Communications Chemistry

Pt(IV) Prodrugs with Non-Steroidal Anti-inflammatory Drugs in the Axial Position

(2022) Daniil V. Spector et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli

(2022) Chuchu Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cisplatin Promotes the Efficacy of Immune Checkpoint Inhibitor Therapy by Inducing Ferroptosis and Activating Neutrophils

(2022) Ziwei Zhou et al.   Frontiers in Pharmacology

Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity

(2022) Xiao Liu et al.   CHEMISTRY & BIODIVERSITY

Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells

(2022) Yan Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in combretastatin A-4 codrugs for cancer therapy

(2022) Kerong Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area

(2022) Daniil V. Spector et al.   INORGANIC CHEMISTRY

Potent Chlorambucil-Platinum(IV) Prodrugs

(2022) Angelico D. Aputen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bioactive Platinum(IV) Complexes Incorporating Halogenated Phenylacetates

(2022) Angelico D. Aputen et al.   MOLECULES

Biotinylated Pt(iv) prodrugs with elevated lipophilicity and cytotoxicity

(2022) Daniil Spector et al.   DALTON TRANSACTIONS

Multi-specific niflumic acid platinum(iv) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage

(2022) Linming Li et al.   DALTON TRANSACTIONS

Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs

(2022) Daniil Spector et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pt(IV)-Deferasirox Prodrug Combats DNA Damage Repair by Regulating RNA N6-Methyladenosine Methylation

(2022) Zheng-Yin Pan et al.   Journal of Medicinal Chemistry

Novel indole–chalcone platinum(IV) complexes as tubulin polymerization inhibitors to overcome oxaliplatin resistance in colorectal cancer

(2022) Xinguang Cao et al.   JOURNAL OF MOLECULAR STRUCTURE

Manganese oxide nano-platforms in cancer therapy: Recent advances on the development of synergistic strategies targeting the tumor microenvironment

(2022) Javier Bonet-Aleta et al.   Applied Materials Today

Novel Pt(IV) complexes to overcome multidrug resistance in gastric cancer by targeting P‐glycoprotein

(2021) Xinguang Cao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pt(IV) Prodrugs with NSAIDs as Axial Ligands

(2021) Daniil Spector et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Platinum(IV) anticancer agents; are we en route to the holy grail or to a dead end?

(2021) Dan Gibson   JOURNAL OF INORGANIC BIOCHEMISTRY

H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

(2021) Ines Batinic-Haberle et al.   Oxidative Medicine and Cellular Longevity

Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment

(2021) Zhong-Ying Ma et al.   BIOCHEMICAL PHARMACOLOGY

Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective Platinum IV Prodrug Against Triple Negative Breast Cancer

(2021) Nafees Muhammad et al.   Chemistry-An Asian Journal

Recent advances in the synthesis, stability, and activation of platinum(IV) anticancer prodrugs

(2021) Zoufeng Xu et al.   COORDINATION CHEMISTRY REVIEWS

GRECO-2: A randomized, phase 2 study of stereotactic body radiation therapy (SBRT) in combination with GC4711 in the treatment of unresectable or borderline resectable nonmetastatic pancreatic cancer (PC).

(2021) Sarah E. Hoffe et al.   JOURNAL OF CLINICAL ONCOLOGY

Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

(2021) Philipp Fronik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

(2021) Claudia Schmidt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional supramolecular systems: design and applications

(2021) I S Antipin et al.   RUSSIAN CHEMICAL REVIEWS

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents

(2021) Vinodh Kannappan et al.   Frontiers in Molecular Biosciences

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

(2021) Thanh Chung Pham et al.   CHEMICAL REVIEWS

Pt(iv) antitumor prodrugs: dogmas, paradigms, and realities

(2021) Mauro Ravera et al.   DALTON TRANSACTIONS

The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(iv) prodrugs

(2021) Shu Chen et al.   DALTON TRANSACTIONS

Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate

(2021) Xin Qiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxoplatin-B, a cisplatin-based platinum(IV) complex with photoactive BODIPY for mitochondria specific “chemo-PDT” activity

(2021) Arpan Bera et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response

(2021) Zuojie Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coordination compounds of biogenic metals as cytotoxic agents in cancer therapy

(2021) Dmitry A. Guk et al.   RUSSIAN CHEMICAL REVIEWS

Multiaction Pt(IV) Carbamate Complexes Can Codeliver Pt(II) Drugs and Amine Containing Bioactive Molecules

(2020) Tomer Babu et al.   INORGANIC CHEMISTRY

Anticancer Melatplatin Prodrugs: High Effect and Low Toxicity, MT1-ER-Target and Immune Response In Vivo

(2020) Xue-Qing Song et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Receptor Radionuclide Therapy with 67Cu-CuSarTATE is Highly Efficacious Against a Somatostatin Positive Neuroendocrine Tumor Model

(2020) Carleen Cullinane et al.   JOURNAL OF NUCLEAR MEDICINE

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

(2020) Zhiqin Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors

(2020) Qian Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bromocoumarinplatin, targeting simultaneously mitochondria and nuclei with p53 apoptosis pathway to overcome cisplatin resistance

(2020) Jing Ma et al.   BIOORGANIC CHEMISTRY

Napabucasin, a novel inhibitor of STAT3, inhibits growth and synergises with doxorubicin in diffuse large B-cell lymphoma

(2020) Xue Li et al.   CANCER LETTERS

BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity

(2020) Houzong Yao et al.   INORGANIC CHEMISTRY

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of Clinical Efficacy of Nano-Albumin Paclitaxel Treatment for Advanced Cell Lung Cancer

(2020) Xiaoxue Li et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

The Lipid Metabolic Landscape of Cancers and New Therapeutic Perspectives

(2020) Wenjun Wang et al.   Frontiers in Oncology

Ligands of G-quadruplex nucleic acids

(2020) Daria V. Andreeva et al.   RUSSIAN CHEMICAL REVIEWS

Anti-tumor platinum (IV) complexes bearing the anti-inflammatory drug naproxen in the axial position

(2019) Dina A. Tolan et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Glucose-conjugated platinum(IV) complexes as tumor-targeting agents: design, synthesis and biological evaluation

(2019) Haifeng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Doubt on a dogma: aquation of equatorial ligands of Pt(IV) complexes under physiological conditions

(2019) Alexander Kastner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-Targeting Dual-Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity

(2019) Maria V. Babak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

An Anticancer Pt IV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects

(2019) Hana Kostrhunova et al.   CHEMISTRY-A EUROPEAN JOURNAL

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo

(2019) Xue-Qing Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression

(2019) Suxing Jin et al.   INORGANIC CHEMISTRY

A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton

(2019) Hana Kostrhunova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fuplatin: An Efficient and Low-Toxic Dual-Prodrug

(2019) Ran Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A view on multi-action Pt(IV) antitumor prodrugs

(2019) Mauro Ravera et al.   INORGANICA CHIMICA ACTA

Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †

(2019) Mauro Ravera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy

(2019) Gaofei Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer

(2019) So-Jin Park et al.   ORAL ONCOLOGY

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

(2019) Thirumal Yempala et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-targeting antitumor conjugates derived from platinum(IV) prodrugs and microtubule inhibitor CA-4 significantly exhibited potent ability to overcome cisplatin resistance

(2019) Xiaochao Huang et al.   BIOORGANIC CHEMISTRY

CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers

(2019) Tim Kong et al.   CANCER RESEARCH

Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response

(2019) Yonglong Zhang et al.   CELL CYCLE

Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

(2019) Markus Kleih et al.   Cell Death & Disease

Classification of Metal-Based Drugs according to Their Mechanisms of Action

(2019) Eszter Boros et al.   Chem

Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light

(2019) Zhigang Wang et al.   Chem

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug

(2018) Lili Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mn porphyrin-based redox-active drugs – Differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury

(2018) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

STAT3, stem cells, cancer stem cells and p63

(2018) Michaela Galoczova et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Why develop photoactivated chemotherapy?

(2018) Sylvestre Bonnet   DALTON TRANSACTIONS

Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells

(2018) Xiaochao Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues

(2018) Xiaochao Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pt(IV) prodrugs containing microtubule inhibitors displayed potent antitumor activity and ability to overcome cisplatin resistance

(2018) Lingxue Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, and in vitro cytotoxicity of a Kiteplatin-Ibuprofen Pt(IV) prodrug

(2018) Alessandra Curci et al.   INORGANICA CHIMICA ACTA

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

(2018) Salvatore Savino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity

(2018) Jingjie Tan et al.   MOLECULAR PHARMACEUTICS

Melatonin: A Molecule for Reducing Breast Cancer Risk

(2018) et al.   MOLECULES

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

(2018) Emanuele Petruzzella et al.   Chemical Science

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment

(2018) Lan Thi Hanh Phi et al.   Stem Cells International

Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo

(2018) Zhong-Ying Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

IR780 loaded perfluorohexane nanodroplets for efficient sonodynamic effect induced by short-pulsed focused ultrasound

(2018) Nan Chang et al.   ULTRASONICS SONOCHEMISTRY

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Advances in antitumor effects of NSAIDs

(2018) Zhen Zhang et al.   Cancer Management and Research

Multi-action Pt(IV) anticancer agents; do we understand how they work?

(2018) Dan Gibson   JOURNAL OF INORGANIC BIOCHEMISTRY

Platinum(IV) Prodrugs - A Step Closer to Ehrlich's Vision?

(2017) Reece G. Kenny et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives

(2017) Tatjana Lazarević et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biotin-Pt (IV)-indomethacin hybrid: A targeting anticancer prodrug providing enhanced cancer cellular uptake and reversing cisplatin resistance

(2017) Weiwei Hu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

May glutamine addiction drive the delivery of antitumor cisplatin-based Pt(IV) prodrugs?

(2017) Mauro Ravera et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models

(2017) Simone Göschl et al.   Metallomics

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

(2017) Josef Mayr et al.   Chemical Science

Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

(2017) Yang Liu et al.   Cell Death & Disease

A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

(2016) Malay Patra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance

(2016) Zhigang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A randomized phase III study of napabucasin [BBI608] (NAPA) vs placebo (PBO) in patients (pts) with pretreated advanced colorectal cancer (ACRC): the CCTG/AGITG CO.23 trial

(2016) D.J. Jonker et al.   ANNALS OF ONCOLOGY

Platinum-based drugs: past, present and future

(2016) Shahana Dilruba et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Sulfonamide chalcones: Synthesis and in vitro exploration for therapeutic potential against Brugia malayi

(2016) Sandeep P. Bahekar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparative toxicities of 3 platinum-containing chemotherapy regimens in relapsed/refractory lymphoma patients

(2016) F. Tixier et al.   HEMATOLOGICAL ONCOLOGY

Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin

(2016) Juraj Zajac et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Prediction of logP for Pt(II) and Pt(IV) complexes: Comparison of statistical and quantum-chemistry based approaches

(2016) Igor V. Tetko et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors

(2016) Dong Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo

(2016) Malay Patra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Melatonin, an inhibitory agent in breast cancer

(2016) Elaheh Nooshinfar et al.   Breast Cancer

Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

(2016) Raji Raveendran et al.   Chemical Science

5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation

(2016) Juan Wang et al.   Oncotarget

BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression

(2016) Hengrui Zhu et al.   Cell Reports

Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(iv)–acetamidato complex

(2015) Giorgio Pelosi et al.   CHEMICAL COMMUNICATIONS

Integrin-targeted delivery into cancer cells of a Pt(iv) pro-drug through conjugation to RGD-containing peptides

(2015) Anna Massaguer et al.   DALTON TRANSACTIONS

Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy

(2015) Mingliang Fan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Carbonic anhydrase IX inhibitors in cancer therapy: an update

(2015) Claudiu T Supuran et al.   Future Medicinal Chemistry

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate

(2015) Rosa Ferriero et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent

(2015) Baoxin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Third row transition metals for the treatment of cancer

(2015) T. C. Johnstone et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

TOOKAD® Soluble focal therapy: pooled analysis of three phase II studies assessing the minimally invasive ablation of localized prostate cancer

(2015) A. R. Azzouzi et al.   WORLD JOURNAL OF UROLOGY

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

(2015) Carol Ward et al.   Oncotarget

The Prodrug Platin-A: Simultaneous Release of Cisplatin and Aspirin

(2014) Rakesh K. Pathak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural modification strategies for the rational design of red/NIR region BODIPYs

(2014) Hua Lu et al.   CHEMICAL SOCIETY REVIEWS

Copper-Free Click-Chemistry Platform to Functionalize Cisplatin Prodrugs

(2014) Rakesh K. Pathak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Molecular Pathways: The Immunogenic Effects of Platinum-Based Chemotherapeutics

(2014) S. V. Hato et al.   CLINICAL CANCER RESEARCH

Metal-based anticancer chemotherapeutic agents

(2014) Nafees Muhammad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A New Entry to Asymmetric Platinum(IV) Complexes via Oxidative Chlorination

(2014) Mauro Ravera et al.   INORGANIC CHEMISTRY

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

(2014) Zhuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery

(2014) Yao-Rong Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

(2014) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detouring of cisplatin to access mitochondrial genome for overcoming resistance

(2014) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway

(2014) Biyin Cao et al.   Scientific Reports

Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer

(2013) Aaron S. Mansfield et al.   ANTI-CANCER DRUGS

The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer

(2013) Jia Zhou et al.   BIOMATERIALS

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Influence of Equatorial and Axial Carboxylato Ligands on the Kinetic Inertness of Platinum(IV) Complexes in the Presence of Ascorbate and Cysteine and within DLD-1 Cancer Cells

(2013) Catherine K. J. Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Understanding platinum-induced ototoxicity

(2013) Thorsten Langer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Copper Complexes as Anticancer Agents

(2012) Cristina Marzano et al.   Anti-Cancer Agents in Medicinal Chemistry

Mechanisms of Cytotoxicity of Anticancer Titanocenes

(2012) Ulrike Olszewski et al.   Anti-Cancer Agents in Medicinal Chemistry

A Better Platinum-Based Anticancer Drug Yet to Come?

(2012) Ulrike Olszewski et al.   Anti-Cancer Agents in Medicinal Chemistry

Combination therapy: Histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer

(2012) Himashinie V.K. Diyabalanage et al.   CANCER LETTERS

Facile Preparation of Mono-, Di- and Mixed-Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

(2012) Jenny Z. Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery and Optimization of a Series of 2-Aryl-4-Amino-5-(3′,4′,5′-trimethoxybenzoyl)Thiazoles as Novel Anticancer Agents

(2012) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning the Activity of Platinum(IV) Anticancer Complexes through Asymmetric Acylation

(2012) Chee Fei Chin et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

(2012) Yan Lu et al.   PHARMACEUTICAL RESEARCH

Bioinorganic Chemistry of Titanium

(2011) Katherine M. Buettner et al.   CHEMICAL REVIEWS

Synthesis, Characterization, and Cytotoxicity of Platinum(IV) Carbamate Complexes

(2011) Justin J. Wilson et al.   INORGANIC CHEMISTRY

Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

(2011) Vineet Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Focused ultrasound modulates region-specific brain activity

(2011) Seung-Schik Yoo et al.   NEUROIMAGE

Novel photosensitisers derived from pyropheophorbide-a: uptake by cells and photodynamic efficiency in vitro

(2010) Ioanna Stamati et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

(2009) Kate Petersen Shay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells

(2009) Anwen M. Krause-Heuer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress induces degradation of mitochondrial DNA

(2009) Inna Shokolenko et al.   NUCLEIC ACIDS RESEARCH