A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action

(2015) Hong Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells

(2015) Rafael Salto et al.   PLoS One

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells

(2013) Dandan Zhang et al.   CANCER SCIENCE

Highly water-soluble platinum(ii) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties

(2013) Pengxing Liu et al.   CHEMICAL COMMUNICATIONS

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glucose conjugation for the specific targeting and treatment of cancer

(2013) Emilia C. Calvaresi et al.   Chemical Science

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Targeting and delivery of platinum-based anticancer drugs

(2012) Xiaoyong Wang et al.   CHEMICAL SOCIETY REVIEWS

Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy

(2012) Tae Rim Kim et al.   FEBS LETTERS

1H NMR study of the reactions between carboplatin analogues [Pt(en)(Me-mal-O,O′)] and [Pt(en)(Me2-mal-O,O′)] and various methionine- and histidine-containing peptides under physiologically relevant conditions

(2012) Snežana Rajković et al.   INORGANICA CHIMICA ACTA

Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues

(2012) Irina Buß et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Design, Synthesis, and Preliminary Biological Evaluation of 6-O-Glucose–Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors

(2012) Piyush Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications

(2012) Woong Hee Kim et al.   SENSORS

Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

(2012) Matthias König et al.   PLoS Computational Biology

F-18 FDG PET/CT for Detection of Malignant Involvement of Peripheral Nerves

(2011) Yulia Bronstein et al.   CLINICAL NUCLEAR MEDICINE

Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)

(2010) H Burger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis

(2010) Gui Fang Guo et al.   MEDICAL ONCOLOGY

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Synthesis of Novel gluco- and galacto-Functionalized Platinum Complexes

(2009) Janina Möker et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

(2009) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes

(2009) Luis Felipe Barros et al.   JOURNAL OF NEUROCHEMISTRY

18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response

(2009) S. Ben-Haim et al.   JOURNAL OF NUCLEAR MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Carbohydrate-Metal Complexes and their Potential as Anticancer Agents

(2008) Christian Hartinger et al.   CURRENT MEDICINAL CHEMISTRY