Article
Medicine, Research & Experimental
Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain
Summary: Cisplatin is an anticancer drug with challenges in drug delivery. Cisplatin(IV) prodrug formation can effectively resolve these challenges. The selection of axial ligands plays a key role in determining the therapeutic outcomes. Rational design of cisplatin(IV) derivatives can improve their stability and cellular uptake, reducing side effects and offering potential in resolving cisplatin drug delivery challenges.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Jiafan Lin, Jishuai Zhang, Ziqi Ma, Xiaoqin Wu, Fuyi Wang, Yao Zhao, Kui Wu, Yi Liu
Summary: The interaction between a photoactivatable Pt(iv) prodrug and human telomeric DNA was studied. Two major mono-platinated DNA adducts were detected, with trans-[Pt-II(N-3)(py)(2)](+) and trans-[Pt-II(py)(2)](2+) as the bound Pt moieties. The platination sites were found to be G(6) and A(3) in one adduct, and a potential intrastrand crosslink was speculated after G(4) and G(6) in the other adduct. Minor platinated adducts and oxidized DNA adducts were also observed. These results provide valuable chemical information about the photoreaction between photoactivatable Pt(iv) anticancer prodrugs and human telomeric DNA.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Shunzhe Zheng, Guanting Li, Jianbin Shi, Xinying Liu, Meng Li, Zhonggui He, Chutong Tian, Ken-ichiro Kamei
Summary: Due to the severe dose-dependent toxicity and drug resistance, platinum (Pt)-based chemotherapy has limitations. Pt(IV) prodrug nanotherapeutics have emerged as a promising approach to improve the antitumor performance of Pt drugs. This article summarizes the latest advances in Pt(IV) prodrug nano-therapeutics, including their potential for overcoming biological barriers and their synergistic effects with other therapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Neelu Singh, Ajay Gupta, Puja Prasad, Raj Kumar Sah, Arvind Singh, Sunil Kumar, Shailja Singh, Shalini Gupta, Pijus K. Sasmal
Summary: A novel drug delivery platform has been developed for targeted and monitored drug release in cancer cells, which can be achieved through photoactivation. The system allows for drug release targeted at mitochondria and temporally controlled cell death within cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. K. Keppler, Christian R. R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Summary: Platinum compounds are effective treatment options for various cancer types, but their use is limited by side effects and drug resistance. A new multi-targeted platinum(IV) prodrug, cisPt(PhB)(2), has shown promising anticancer activity and the ability to overcome drug resistance mechanisms. The drug's mode of action is influenced by cellular fatty acid metabolism and mitochondrial activity. Specifically, it is more effective against cisplatin-resistant cancer cells with Warburg-like properties. This orally applicable prodrug has the potential to improve cancer treatment outcomes.
Article
Chemistry, Physical
Stefano Scoditti, Eslam Dabbish, German E. Pieslinger, Elixabete Rezabal, Xabier Lopez, Emilia Sicilia, Luca Salassa
Summary: The mechanism for the photocatalytic activation of Pt(iv) anticancer prodrugs by riboflavin in the presence of NADH has been investigated. The results demonstrate that riboflavin accelerates the hydride transfer from NADH to riboflavin in the excited state, and facilitates the reduction of Pt(iv) complexes via an inner sphere mechanism.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Jingjing Huang, Weize Ding, Xingfan Zhu, Bingbing Li, Fangang Zeng, Kui Wu, Xiaoqin Wu, Fuyi Wang
Summary: This article reviews the development of photoactivatable Pt(IV) anticancer prodrugs, focusing on the coordinated ligands and their effects on the photochemistry and photoactivity of the drugs. These drugs offer higher spatial and temporal controllability and improved safety compared to traditional chemotherapy.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoqian Zhao, Guoshan Zhang, Jianlin Ke, Jianguo Wang, Hongqing Zhuo
Summary: Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths. Finding a suitable drug delivery system for gastric cancer chemotherapy has been of great value. Platinum-based drugs, while popular, have severe side effects that limit their use. Pt(IV) prodrugs and nanocarriers may be the future of platinum-based drugs.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Li, Weiheng Zhao, Chen Jin, Huihua Xiong
Summary: In this study, a series of platinum(IV) complexes with 4-amino-quinazoline as ligands were synthesized and evaluated for their anticancer activities. Among them, 17b exhibited higher cytotoxicity against lung cancer cells and lower cytotoxicity towards normal cells, suggesting it as a novel strategy to overcome resistance to platinum(II) drugs.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zibo Li, Qing Xu, Xuefeng Lin, Kunyi Yu, Ling Lin, Yangjia Liu, Zhiqiang Yu, Tiancai Liu, Dixian Luo
Summary: A promising liposomal drug CholesPt(IV)-Liposomes was synthesized to overcome the limitations of platinum-based anticancer agents, such as poor water-solubility and chemoresistance. The liposomes showed small particle size, rapid release of platinum ions, and significant apoptosis of cancer cells. In animal experiments, CholesPt(IV)-Liposomes demonstrated better therapeutic effect and reduced drug toxicity compared to traditional platinum drugs.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Physical
Juan Gurruchaga-Pereda, Virginia Martinez-Martinez, Elena Formoso, Oksana Azpitarte, Elixabete Rezabal, Xabier Lopez, Aitziber L. Cortajarena, Luca Salassa
Summary: Our recent research shows that protein engineering can enhance the catalytic capacity of certain flavoproteins towards metal-containing substrates. By using site-directed mutagenesis, the photocatalytic activity of flavoprotein towards Pt(IV) substrates can be modulated. Among the mutants prepared, Q103V mSOG exhibited improved catalytic efficiency due to its longer triplet excited-state lifetime.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Yue Yu, Liping Sun, Yanfei Tang, Huixia Zhu, Huai Wang, Hua Xiao, Feng Wang, Wei Tao
Summary: Encapsulating cisplatin in calcium phosphate nanoparticles is challenging due to its low solubility and weak binding affinity. This study presents a unique strategy using a polymer bearing numerous carboxyl side groups and incorporating redox-sensitive cisplatin prodrugs for encapsulation in CPNPs. The encapsulated CPNPs showed enhanced stability and efficacy against cancerous cells compared to free cisplatin and the prodrug alone.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Biyun Ren, Bing Chen, Jianxiong Zhao, Yang Guo, Xin Zhang, Xian Chen, Yangyang Du, Zhiqin Deng, Guangyu Zhu, Feng Wang
Summary: Lanthanide-doped ScF3 nanoparticles were synthesized and studied for their thermal enhancement of upconversion, showing a significant increase in emission within a certain temperature range and high temperature sensitivity. The development of new methods may inspire the creation of thermally enhanced upconversion nanoparticles with high emission intensities.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Bo Li, Jiahua Liu, Fucong Lyu, Zhiqin Deng, Bo Yi, Peng Du, Xi Yao, Guangyu Zhu, Zhengtao Xu, Jian Lu, Yang Yang Li
Summary: This study introduces a novel hydrogel synthesized from water and inorganic salts, offering high ionic conductivity and energy density. The gel is biocompatible and sheds light on prebiotic evolution.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Environmental
Binbin Zhou, Weihui Ou, Chenghao Zhao, Junda Shen, Guobin Zhang, Xianghu Tang, Zhiqin Deng, Guangyu Zhu, Yang Yang Li, Jian Lu
Summary: A novel strategy for mass fabrication of SERS sensors through electrochemical nanoetching of commercial Ag needles has been reported in this study. These sensors feature rich surface nanostructures of ultrahigh SERS sensitivity, allowing for on-site detection and depth-profile information retrieval from products such as purine, proteins, and lipids, while also exhibiting strong durability and repeatability.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Shu Chen, Ka-Yan Ng, Qiyuan Zhou, Houzong Yao, Zhiqin Deng, Man-Kit Tse, Guangyu Zhu
Summary: This study synthesized six mono-carbonated Pt(iv) complexes with axial carbonate ligands of various electron-withdrawing abilities, and prepared corresponding mono-carboxylated analogues as references to investigate the differences in hydrolysis and reduction rates. It was found that mono-carbonated Pt(iv) complexes are less stable and reduced faster compared to mono-carboxylated ones, and the hydrolysis and reduction profiles depend on both the electron-withdrawing ability of the carbonates and the nature of the opposite axial ligands.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Houzong Yao, Zhigang Wang, Na Wang, Zhiqin Deng, Gongyuan Liu, Jianghong Zhou, Shu Chen, Jiahai Shi, Guangyu Zhu
Summary: This study presents a rational design of a platinum(IV) anticancer prodrug that can bind to erythrocytes, greatly extending its circulatory half-life and enhancing tumor accumulation. The prodrug demonstrates significantly enhanced antitumor activity and reduced side effects compared to carboplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Zhiqin Deng, Guangyu Zhu
Summary: The development of novel chemotherapeutic metallo-drugs with improved efficacies has been inspired by the clinical application of Pt-based anticancer drugs. Pt(IV) prodrugs have shown great anticancer performance and can overcome the limitations of conventional Pt(II) drugs through judicious modification of axial ligands. This review summarizes recent developments in Pt(IV) anticancer complexes, focusing on their axial functionalization with other anticancer agents, immunotherapeutic agents, photosensitive ligands, peptides, and theranostic agents. It is hoped that this concise overview of Pt(IV) coordination complexes will aid researchers in designing next-generation multi-functional anti-cancer agents based on a comprehensive Pt(IV) platform.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qiaolin Yan, Meng Duan, Cien Chen, Zhiqing Deng, Mandi Wu, Peiyuan Yu, Ming-Liang He, Guangyu Zhu, K. N. Houk, Jianwei Sun
Summary: This study demonstrates excellent enantioselection between aryl and heteroaryl groups using a robust organocatalytic system. By studying the versatile 2-indole imine methide, highly enantioenriched indole-containing triarylmethanes were synthesized, and the mechanism was explored through control experiments and kinetic studies. Preliminary biological studies also indicate the potential of these compounds for anticancer and antiviral drug development.
Article
Chemistry, Multidisciplinary
Na Wang, Zhiqin Deng, Qi Zhu, Jianxiong Zhao, Kai Xie, Peng Shi, Zhigang Wang, Xianfeng Chen, Feng Wang, Jiahai Shi, Guangyu Zhu
Summary: This study introduces an erythrocyte-delivered and NIR photoactivatable Pt-IV nanoprodrug that enhances accumulation in tumors, reduces side effects, and releases oxaliplatin in a controllable manner to achieve significant antitumor activity.
Review
Nanoscience & Nanotechnology
Zhiqin Deng, Na Wang, Fujin Ai, Zhigang Wang, Guangyu Zhu
Summary: Platinum-based drugs play a crucial role in cancer chemotherapy but are limited by side effects and drug resistance. The application of nanotechnology offers opportunities to overcome these limitations, with nanoparticles co-loading platinum drugs and other anticancer agents enhancing synergistic efficacy and pharmacokinetic properties, favoring cancer treatment.
Article
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Wai Kit Tang, Qiyuan Zhou, Shu Chen, Chi-Kit Siu, Guangyu Zhu
Summary: The study revealed that the hydrolytic stability of Pt(iv) complexes is influenced by other ligands, with successful application to improve the stability of Pt(iv) complexes containing axial dichloroacetate ligands.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Zhiqin Deng, Cai Li, Shu Chen, Qiyuan Zhou, Zoufeng Xu, Zhigang Wang, Houzong Yao, Hajime Hirao, Guangyu Zhu
Summary: Selective activation of prodrugs at diseased tissue through bioorthogonal catalysis using Pt(iv) complexes with internal photoswitches shows promise for precision cancer treatment. These complexes exhibit significantly increased photoconversion efficiency and photocytotoxicity compared to conventional platforms, demonstrating potential for highly effective prodrugs in medical applications.
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)