Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents
Authors
Keywords
-
Journal
Frontiers in Molecular Biosciences
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-09-17
DOI
10.3389/fmolb.2021.741316
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Disulfiram: a novel repurposed drug for cancer therapy
- (2021) Chen Lu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative
- (2021) Man Pan et al. Nature Communications
- Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System against Chemoresistant Triple Negative Breast Cancer Cell Lines
- (2021) Ammar Said Suliman et al. Pharmaceutics
- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Copper: An intracellular Achilles heel allowing the targeting of epigenetics, kinase pathways and cell metabolism in cancer therapeutics
- (2021) Filip Michniewicz et al. ChemMedChem
- Kinase drug discovery 20 years after imatinib: progress and future directions
- (2021) Philip Cohen et al. NATURE REVIEWS DRUG DISCOVERY
- Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization
- (2021) Luke Koog et al. Advanced Healthcare Materials
- EMT and Cancer Cell Stemness Associated With Chemotherapeutic Resistance in Esophageal Cancer
- (2021) Xiaojie Liu et al. Frontiers in Oncology
- An Arm and a Leg: The Rising Cost of Cancer Drugs and Impact on Access
- (2021) Natasha B. Leighl et al. American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
- Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAFV600E-driven melanoma
- (2020) Ye-Jin Kim et al. CANCER RESEARCH
- Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells
- (2020) Francesca Rolle et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration
- (2020) Stéphanie Blockhuys et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways
- (2020) Yiqiu Li et al. Cancers
- Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway
- (2020) Dusana Majera et al. Cells
- Small molecules, big impact: 20 years of targeted therapy in oncology
- (2020) Philippe L Bedard et al. LANCET
- Evaluation of the accumulation of disulfiram and its copper complex in A549 cells using mass spectrometry
- (2020) Xinling Lu et al. TALANTA
- Life, death, and autophagy in cancer: NF-κB turns up everywhere
- (2020) Daniela Verzella et al. Cell Death & Disease
- Disulfiram/copper markedly induced myeloma cell apoptosis through activation of JNK and intrinsic and extrinsic apoptosis pathways
- (2020) Yaqi Xu et al. BIOMEDICINE & PHARMACOTHERAPY
- Copper homeostasis: Emerging target for cancer treatment
- (2020) Yueqin Li IUBMB LIFE
- Epithelial–mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts
- (2020) Xuefeng Xuefeng et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma
- (2020) Hirofumi Yoshino et al. PLoS One
- Copper metabolism as a unique vulnerability in cancer
- (2020) Vinit C. Shanbhag et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
- (2020) Florida Voli et al. CANCER RESEARCH
- Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy
- (2020) Nur Aininie Yusoh et al. ChemMedChem
- Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
- (2020) Sang Yeul Lee et al. Drug Design Development and Therapy
- The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy
- (2020) Pierre Lelièvre et al. Cancers
- Disulfiram-loaded functionalized magnetic nanoparticles combined with copper and sodium nitroprusside in breast cancer cells
- (2020) Kübra Solak et al. Materials Science & Engineering C-Materials for Biological Applications
- ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis
- (2019) Vinit Shanbhag et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors
- (2019) Parikshit Banerjee et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Disulfiram modulates ROS accumulation and overcomes synergistically cisplatin resistance in breast cancer cell lines
- (2019) Zhi Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Repurposing Disulfiram as an Anti-Cancer Agent: Updated Review on Literature and Patents
- (2019) Elmira Ekincia et al. Recent Patents on Anti-Cancer Drug Discovery
- Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
- (2019) Zdenek Skrott et al. ONCOGENE
- Disulfiram Overcomes Cisplatin Resistance in Human Embryonal Carcinoma Cells
- (2019) Silvia Schmidtova et al. Cancers
- Inhibitory effect on ovarian cancer ALDH+ stem-like cells by Disulfiram and Copper treatment through ALDH and ROS modulation
- (2019) Fang Guo et al. BIOMEDICINE & PHARMACOTHERAPY
- Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy
- (2019) Seyedeh Alia Moosavian et al. SEMINARS IN CANCER BIOLOGY
- Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment
- (2019) Mohammad Najlah et al. Pharmaceutics
- Antitumor effects of disulfiram/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel
- (2019) Xiao Xu et al. BIOMEDICINE & PHARMACOTHERAPY
- Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line
- (2018) Kate Butcher et al. BMC CANCER
- Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors
- (2018) Nan-nan Wang et al. EXPERIMENTAL CELL RESEARCH
- Disulfiram/copper targets stem cell-like ALDH+ population of multiple myeloma by inhibition of ALDH1A1 and Hedgehog pathway
- (2018) Na Jin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Disulfiram-loaded mixed nanoparticles with high drug-loading and plasma stability by reducing the core crystallinity for intravenous delivery
- (2018) Xuezhi Zhuo et al. JOURNAL OF COLLOID AND INTERFACE SCIENCE
- mPEG5k-b-PLGA2k/PCL3.4k/MCT Mixed Micelles as Carriers of Disulfiram for Improving Plasma Stability and Antitumor Effect in Vivo
- (2018) Linlin Miao et al. MOLECULAR PHARMACEUTICS
- Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy
- (2018) Pengfei Zhao et al. Chemical Science
- Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
- (2018) Nan Ding et al. Translational Cancer Research
- Examining Trends in Cost and Clinical Benefit of Novel Anticancer Drugs Over Time
- (2018) Ronak Saluja et al. Journal of Oncology Practice
- Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer
- (2017) Mohammad Najlah et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer
- (2017) Chenhui Wang et al. International Journal of Nanomedicine
- pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer
- (2017) Qiang Huo et al. International Journal of Nanomedicine
- Polymeric micelles: Basic research to clinical practice
- (2017) Anand S. Deshmukh et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Polymeric nanoparticles: Promising platform for drug delivery
- (2017) Khalid M. El-Say et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways
- (2017) Yi Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Recent views of heavy metals as possible risk factors and potential preventive and therapeutic agents in prostate cancer
- (2017) Veronica Vella et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells
- (2017) Zhipeng Wang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2
- (2017) Bing Xu et al. Cell Death & Disease
- Metal complexes in cancer therapy – an update from drug design perspective
- (2017) Umar Ndagi et al. Drug Design Development and Therapy
- Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts
- (2017) Hanumantha Rao Madala et al. Oncotarget
- Combination of Fe/Cu –chelators and docosahexaenoic acid: an exploration for the treatment of colorectal cancer
- (2017) Nanhui Yu et al. Oncotarget
- Development of a copper-clioquinol formulation suitable for intravenous use
- (2017) Moe Wehbe et al. Drug Delivery and Translational Research
- Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients
- (2016) Abdulkerim Kasim Baltaci et al. BIOLOGICAL TRACE ELEMENT RESEARCH
- Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy
- (2016) Wantong Song et al. Nanomedicine-Nanotechnology Biology and Medicine
- Assessment of serum copper, iron and immune complexes in potentially malignant disorders and oral cancer
- (2016) Ritu TIWARI et al. Brazilian Oral Research
- Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations
- (2016) Hamidreza Fasehee et al. JOURNAL OF NANOBIOTECHNOLOGY
- Effects of Acute Lymphoblastic Leukemia on Ceruloplasmin Oxidase, Copper and Several Markers of Oxidative Damage, in Children
- (2015) Wesen Adel Mehdi et al. Asian Pacific Journal of Cancer Prevention
- Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria
- (2015) ML Adeoti et al. INDIAN JOURNAL OF CANCER
- Hot melt extruded and injection moulded disulfiram-loaded PLGA millirods for the treatment of glioblastoma multiforme via stereotactic injection
- (2015) Christopher McConville et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Drug repurposing in oncology—patient and health systems opportunities
- (2015) Francesco Bertolini et al. Nature Reviews Clinical Oncology
- Copper activates HIF-1α/GPER/VEGF signalling in cancer cells
- (2015) Damiano Cosimo Rigiracciolo et al. Oncotarget
- The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
- (2015) Patricia Erebi Tawari et al. Toxicology Research
- Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria
- (2015) ML Adeoti et al. INDIAN JOURNAL OF CANCER
- Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide
- (2015) Joanna Triscott et al. Oncotarget
- Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo
- (2015) Peng Liu et al. Oncotarget
- Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis
- (2014) G. P. Nagaraju et al. CARCINOGENESIS
- Oxidizing to death
- (2014) Ansgar Brüning et al. CELL CYCLE
- On the interaction of copper(ii) with disulfiram
- (2014) David J. Lewis et al. CHEMICAL COMMUNICATIONS
- Aldehyde dehydrogenases in cancer: an opportunity for biomarker and drug development?
- (2014) Klaus Pors et al. DRUG DISCOVERY TODAY
- Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China
- (2014) Xiao Ding et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells
- (2014) Joan Fernando et al. INTERNATIONAL JOURNAL OF CANCER
- Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram
- (2014) Xiaopin Duan et al. NANOTECHNOLOGY
- Copper is required for oncogenic BRAF signalling and tumorigenesis
- (2014) Donita C. Brady et al. NATURE
- Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners
- (2014) Tetsuhiro Chiba et al. PLoS One
- Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis
- (2014) G. MacDonald et al. Science Signaling
- Serum levels of ferritin, copper, and zinc in patients with oral cancer
- (2014) Hamed Mortazavi et al. Biomedical Journal
- Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells
- (2013) P Liu et al. BRITISH JOURNAL OF CANCER
- D-penicillamine and other low molecular weight thiols: Review of anticancer effects and related mechanisms
- (2013) Saurabh Wadhwa et al. CANCER LETTERS
- The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease
- (2013) Natalie K.Y. Wee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- P38/NF-κB/Snail Pathway Is Involved in Caffeic Acid-Induced Inhibition of Cancer Stem Cells-Like Properties and Migratory Capacity in Malignant Human Keratinocyte
- (2013) Ye Yang et al. PLoS One
- Bioavailable copper modulates oxidative phosphorylation and growth of tumors
- (2013) S. Ishida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heavy and Trace Metals in Carcinoma of the Gallbladder
- (2013) Somprakas Basu et al. WORLD JOURNAL OF SURGERY
- Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
- (2012) P Liu et al. BRITISH JOURNAL OF CANCER
- Copper levels in patients with hematological malignancies
- (2012) Georgia D. Kaiafa et al. European Journal of Internal Medicine
- Gallium-containing anticancer compounds
- (2012) Christopher R Chitambar Future Medicinal Chemistry
- Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells
- (2012) TAO HUANG et al. ONCOLOGY REPORTS
- Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer
- (2011) Michael A. Cater et al. BIOCHEMICAL JOURNAL
- Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- (2011) N C Yip et al. BRITISH JOURNAL OF CANCER
- Disulfiram, and Disulfiram Derivatives as Novel Potential Anticancer Drugs Targeting the Ubiquitin Proteasome System in Both Preclinical and Clinical Studies
- (2011) F. R. Kona et al. CURRENT CANCER DRUG TARGETS
- Serum total oxidant/antioxidant status and trace element levels in breast cancer patients
- (2011) Jia-Fu Feng et al. International Journal of Clinical Oncology
- Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: A hospital based case–control study in China
- (2010) Yongtang Jin et al. Cancer Epidemiology
- Novel Metals and Metal Complexes as Platforms for Cancer Therapy
- (2010) Michael Frezza et al. CURRENT PHARMACEUTICAL DESIGN
- Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma
- (2010) Brian W. Morrison et al. MELANOMA RESEARCH
- Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
- (2009) Yadi Wu et al. CANCER CELL
- Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
- (2009) Xiaoxia Guo et al. CANCER LETTERS
- Disseminated Tumor Cells in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease Predicts Biochemical Recurrence
- (2009) T. M. Morgan et al. CLINICAL CANCER RESEARCH
- Role of Copper in Angiogenesis and Its Medicinal Implications
- (2009) Huiqi Xie et al. CURRENT MEDICINAL CHEMISTRY
- COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION
- (2008) Lydia Finney et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- The value of proteasome inhibition in cancer
- (2008) Boris Cvek et al. DRUG DISCOVERY TODAY
- Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells
- (2008) Boris Cvek et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
- (2007) Melissa R. Junttila et al. FASEB JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started