Amlexanox-modified platinum(IV) complex triggers apoptotic and autophagic bimodal death of cancer cells

Pt(IV) Prodrugs with NSAIDs as Axial Ligands

(2021) Daniil Spector et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

δ‐Tocotrienol sensitizes and re‐sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK‐mediated apoptosis

(2021) Fabrizio Fontana et al.   CELL PROLIFERATION

Autophagy is a major metabolic regulator involved in cancer therapy resistance

(2021) Laura Poillet-Perez et al.   Cell Reports

Calcium Signaling Regulates Autophagy and Apoptosis

(2021) Pramod Sukumaran et al.   Cells

19 F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions

(2021) Siming Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate

(2021) Xin Qiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer

(2021) Fabrizio Fontana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria-targeted Pt(IV) prodrugs conjugated with an aggregation-induced emission luminogen against breast cancer cells by dual modulation of apoptosis and autophagy inhibition

(2021) Yan Su et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

DNA-Unresponsive Platinum(II) Complex Induces ERS-Mediated Mitophagy in Cancer Cells

(2021) Yan Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways

(2020) Moritz Möller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activatable Mitochondria‐Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy

(2020) Xiangjie Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex

(2019) Kun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer

(2019) Ryan T. Bishop et al.   CANCER LETTERS

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression

(2019) Suxing Jin et al.   INORGANIC CHEMISTRY

Mitochondria as playmakers of apoptosis, autophagy and senescence

(2019) Marianna Abate et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Enhancing Cytotoxicity of a Monofunctional Platinum Complex via a Dual-DNA-Damage Approach

(2019) Yan Guo et al.   INORGANIC CHEMISTRY

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

(2019) Lele Zhu et al.   NATURE CELL BIOLOGY

Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield

(2018) Muhammad Zaeem Noman et al.   Autophagy

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Towards rational design of RAD51-targeting prodrugs: platinumIV–artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells

(2018) Shuren Zhang et al.   CHEMICAL COMMUNICATIONS

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions

(2017) Susanne Meßling et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway

(2017) Shengtao Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

(2017) Yang Liu et al.   Cell Death & Disease

Enhanced antitumor efficacy of cisplatin for treating ovarian cancer in vitro and in vivo via transferrin binding

(2017) Huifang Peng et al.   Oncotarget

Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts

(2017) Dongfang Hu et al.   Scientific Reports

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance

(2016) Zhigang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

A New Approach to Sensitize Antitumor Monofunctional Platinum(II) Complexes via Short Time Photo-Irradiation

(2016) Xuling Xue et al.   INORGANIC CHEMISTRY

An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

(2015) Albert Gandioso et al.   CHEMICAL COMMUNICATIONS

An inhibition of p62/SQSTM1 caused autophagic cell death of several human carcinoma cells

(2014) Kaito Nihira et al.   CANCER SCIENCE

The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma

(2014) G Tufo et al.   CELL DEATH AND DIFFERENTIATION

Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin

(2013) Wen-Jie Guo et al.   Autophagy

The Role of Calcium Stores in Apoptosis and Autophagy

(2013) S. S. Smaili et al.   CURRENT MOLECULAR MEDICINE

Anticancer Potency of Platinum(II) Complexes Containing Both Chloride Anion and Chelated Carboxylate as Leaving Groups

(2013) Jian Zhao et al.   INORGANIC CHEMISTRY

Selective Detection and Inhibition of Active Caspase-3 in Cells with Optimized Peptides

(2013) Chris J. Vickers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

(2013) Sukhendu Maiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autophagy protein p62/SQSTM1 is involved in HAMLET-induced cell death by modulating apotosis in U87MG cells

(2013) Y-B Zhang et al.   Cell Death & Disease

BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions

(2012) Victoria Del Gaizo Moore et al.   CANCER LETTERS

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

(2011) C. G. Twitty et al.   CLINICAL CANCER RESEARCH

Pt(IV) complexes as prodrugs for cisplatin

(2011) Yi Shi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL