Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs

(2020) Maja Thim Larsen et al.   JOURNAL OF CONTROLLED RELEASE

The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch

(2020) Elisa Wirthgen et al.   Frontiers in Immunology

Stability, Reduction, and Cytotoxicity of Platinum(IV) Anticancer Prodrugs Bearing Carbamate Axial Ligands: Comparison with Their Carboxylate Analogues

(2020) Shu Chen et al.   INORGANIC CHEMISTRY

Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemo-immunotherapy of colorectal cancer

(2020) Fengyun Shen et al.   BIOMATERIALS

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy

(2018) Na Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Indoleamine 2,3-Dioxygenase (IDO) Inhibition as a Strategy to Augment Cancer Immunotherapy

(2018) Sarah Yentz et al.   BIODRUGS

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

(2018) Yu-Hsuan Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Harnessing albumin as a carrier for cancer therapies

(2018) Ella N. Hoogenboezem et al.   ADVANCED DRUG DELIVERY REVIEWS

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

(2018) Bing Feng et al.   ADVANCED MATERIALS

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

Multi-action Pt(IV) anticancer agents; do we understand how they work?

(2018) Dan Gibson   JOURNAL OF INORGANIC BIOCHEMISTRY

Aldoxorubicin for the treatment of soft tissue sarcoma

(2017) Esha Sachdev et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes

(2017) Doris Höfer et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

(2017) Josef Mayr et al.   Chemical Science

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

(2017) Alice Coletti et al.   MedChemComm

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Platinum coordination compounds with potent anticancer activity

(2017) Krishant M. Deo et al.   COORDINATION CHEMISTRY REVIEWS

flowAI: automatic and interactive anomaly discerning tools for flow cytometry data

(2016) Gianni Monaco et al.   BIOINFORMATICS

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

(2016) Qingpeng Wang et al.   DALTON TRANSACTIONS

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs

(2016) Simone Göschl et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

(2016) Barbara Bernardim et al.   Nature Communications

Platinum Antitumor Complexes: 50 Years Since Barnett Rosenberg's Discovery

(2015) Franco M. Muggia et al.   JOURNAL OF CLINICAL ONCOLOGY

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells

(2015) Ivana Campia et al.   PLoS One

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Albumin and its application in drug delivery

(2014) Darrell Sleep   Expert Opinion on Drug Delivery

Safety and efficacy evaluation of albumin-bound paclitaxel

(2014) Sara Cecco et al.   Expert Opinion On Drug Safety

IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis

(2014) L. M. F. Merlo et al.   JOURNAL OF IMMUNOLOGY

Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950): GC-MS, LC-MS, NMR, and Clinical Laboratory Analyses, Libraries, and Web-Based Resources

(2013) Yamil Simón-Manso et al.   ANALYTICAL CHEMISTRY

Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery

(2013) Verena Pichler et al.   CHEMICAL COMMUNICATIONS

Facile Preparation of Mono-, Di- and Mixed-Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

(2012) Jenny Z. Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory

(2012) Rachael M. Crist et al.   Integrative Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

(2011) Jenny Z. Zhang et al.   CHEMICAL COMMUNICATIONS

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

(2010) A. Curti et al.   HAEMATOLOGICA

Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

(2009) Feng Qian et al.   CANCER RESEARCH

The sodium pump α1 sub-unit: a disease progression-related target for metastatic melanoma treatment

(2009) Véronique Mathieu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resistance against novel anticancer metal compounds: Differences and similarities

(2008) P HEFFETER et al.   DRUG RESISTANCE UPDATES

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE