Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response

Pt(IV) Prodrugs with NSAIDs as Axial Ligands

(2021) Daniil Spector et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment

(2021) Zhong-Ying Ma et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of new mono naphthalimide platinum(IV) derivatives as antitumor agents with dual DNA damage mechanism

(2020) Zuojie Li et al.   MONATSHEFTE FUR CHEMIE

Ototoxicity and Platinum Uptake Following Cyclic Administration of Platinum-Based Chemotherapeutic Agents

(2020) Benjamin K. Gersten et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Novel Pt(IV) Prodrugs Displaying Antimitochondrial Effects

(2020) Leila Tabrizi et al.   MOLECULAR PHARMACEUTICS

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Platinum(IV) antitumor complexes and their nano-drug delivery

(2020) Chunyan Jia et al.   COORDINATION CHEMISTRY REVIEWS

Anti-tumor platinum (IV) complexes bearing the anti-inflammatory drug naproxen in the axial position

(2019) Dina A. Tolan et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Inflammation as a Target in Cancer Therapy

(2019) Sonia Leon-Cabrera et al.   MEDIATORS OF INFLAMMATION

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo

(2019) Xue-Qing Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A view on multi-action Pt(IV) antitumor prodrugs

(2019) Mauro Ravera et al.   INORGANICA CHIMICA ACTA

Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †

(2019) Mauro Ravera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma

(2019) Xiaochen Wang et al.   JOURNAL OF HEPATOLOGY

A potent aminonaphthalimide platinum(IV) complex with effective antitumor activities in vitro and in vivo displaying dual DNA damage effects on tumor cells

(2019) Qingpeng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents

(2019) Hanfang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

(2019) Wen-qiang Cao et al.   PHARMACEUTICAL BIOLOGY

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Synthesis, characterization, and in vitro cytotoxicity of a Kiteplatin-Ibuprofen Pt(IV) prodrug

(2018) Alessandra Curci et al.   INORGANICA CHIMICA ACTA

A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity

(2018) Jingjie Tan et al.   MOLECULAR PHARMACEUTICS

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

(2018) Emanuele Petruzzella et al.   Chemical Science

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Inflammation and cancer

(2018) Mariko Murata   Environmental Health and Preventive Medicine

Advances in antitumor effects of NSAIDs

(2018) Zhen Zhang et al.   Cancer Management and Research

Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery

(2017) Jing Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

(2017) Gerardo Botti et al.   Journal of Translational Medicine

COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

(2017) Victor Prima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

(2017) Zijun Y. Xu-Monette et al.   Frontiers in Immunology

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

(2016) Qingpeng Wang et al.   DALTON TRANSACTIONS

Metal-based drugs that break the rules

(2016) Claire S. Allardyce et al.   DALTON TRANSACTIONS

CTC immune escape mediated by PD-L1

(2016) Xuefei Wang et al.   MEDICAL HYPOTHESES

Asplatin enhances drug efficacy by altering the cellular response

(2016) Qinqin Cheng et al.   Metallomics

Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells

(2016) YANLI WANG et al.   ONCOLOGY REPORTS

Combined Chemo-Anti-Inflammatory Prodrugs and Nanoparticles

(2016) Shanta Dhar et al.   SYNLETT

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Cancer Metastases: So Close and So Far

(2015) Carlos Sonnenschein et al.   JNCI-Journal of the National Cancer Institute

Cancer Metastases: So Close and So Far

(2015) Carlos Sonnenschein et al.   JNCI-Journal of the National Cancer Institute

The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

(2014) Qinqin Cheng et al.   CHEMICAL COMMUNICATIONS

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Inflammasomes in cancer: a double-edged sword

(2014) Ryan Kolb et al.   Protein & Cell

The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells

(2013) Ilaria Zanellato et al.   Metallomics

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma

(2008) Setsuya Kamei et al.   JOURNAL OF ORTHOPAEDIC RESEARCH