Pt(IV)-Deferasirox Prodrug Combats DNA Damage Repair by Regulating RNA N6-Methyladenosine Methylation

Role of iron in cancer

(2021) Konstantin Salnikow   SEMINARS IN CANCER BIOLOGY

Recent advances in the synthesis, stability, and activation of platinum(IV) anticancer prodrugs

(2021) Zoufeng Xu et al.   COORDINATION CHEMISTRY REVIEWS

Chromatin and transcriptional regulation by reversible RNA methylation

(2021) Jiangbo Wei et al.   CURRENT OPINION IN CELL BIOLOGY

What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives

(2021) Kun Peng et al.   COORDINATION CHEMISTRY REVIEWS

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells

(2020) Yabing Chen et al.   Autophagy

CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors

(2020) Qian Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria‐Targeted Rhenium(I) Complexes

(2020) Zheng‐Yin Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

(2020) Canfeng Zhang et al.   MOLECULAR CELL

CD44 regulates epigenetic plasticity by mediating iron endocytosis

(2020) Sebastian Müller et al.   Nature Chemistry

Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

(2020) Suxing Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regulating Tumor N 6 ‐Methyladenosine Methylation Landscape using Hypoxia‐Modulating OsS x Nanoparticles

(2020) Yue Zheng et al.   Small

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

(2019) Yongtai Bai et al.   MOLECULAR CELL

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

(2019) Yuhang Jiang et al.   Nature Communications

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

High expression of PRKDC promotes breast cancer cell growth via p38 MAPK signaling and is associated with poor survival

(2019) Yan Zhang et al.   Molecular Genetics & Genomic Medicine

A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy

(2018) Na Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent PtIV Anticancer Prodrug

(2018) Lili Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast

(2018) Kim Kiat Lim et al.   NUCLEIC ACIDS RESEARCH

Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases

(2018) Caitlyn Q Herr et al.   TRENDS IN BIOCHEMICAL SCIENCES

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

PRKDC regulates chemosensitivity and is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients

(2017) Gang Sun et al.   ONCOLOGY REPORTS

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin Resistance

(2016) Zhigang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(iv) prodrug with unique mode of action

(2015) Lili Ma et al.   CHEMICAL COMMUNICATIONS

A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy

(2015) Samuel G. Awuah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

IRP2 Regulates Breast Tumor Growth

(2013) Wei Wang et al.   CANCER RESEARCH

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents

(2012) Nicolai J. Birkbak et al.   Cancer Discovery

An Iron Regulatory Gene Signature Predicts Outcome in Breast Cancer

(2011) L. D. Miller et al.   CANCER RESEARCH

Functional relevance of the histone  H2Ax in the response to DNA damaging agents

(2011) I. Revet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Ferritin Heavy Chain–Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production Are Essential for Epithelial-Mesenchymal Transition

(2009) Ke-Hua Zhang et al.   CANCER RESEARCH