Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation

(2017) Liang Lu et al.   Cell Death & Disease

IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR

(2016) S. Challa et al.   CANCER RESEARCH

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

(2016) Biao Ma et al.   Nature Communications

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

(2015) Shannon M. Reilly et al.   Nature Communications

Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss

(2015) Yong Zhang et al.   Scientific Reports

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

(2014) Thanh U. Barbie et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

(2014) Biao Ma et al.   NATURE CELL BIOLOGY

The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy

(2013) Hai Wang et al.   CANCER AND METASTASIS REVIEWS

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

IKBKE Phosphorylation and Inhibition of FOXO3a: A Mechanism of IKBKE Oncogenic Function

(2013) Jian-Ping Guo et al.   PLoS One

I B Kinase   Phosphorylates TRAF2 To Promote Mammary Epithelial Cell Transformation

(2012) R. R. Shen et al.   MOLECULAR AND CELLULAR BIOLOGY

Beneficial effects of IKKε-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice

(2011) Ludger Scheja et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The origins of glioma: E Pluribus Unum?

(2011) F. A. Siebzehnrubl et al.   GLIA

KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

(2011) Ling Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Kinase IKK  Is a Potential Target for the Treatment of Inflammatory Hyperalgesia

(2011) C. V. Moser et al.   JOURNAL OF IMMUNOLOGY

Yes-Associated Protein 1 Is Widely Expressed in Human Brain Tumors and Promotes Glioblastoma Growth

(2011) Brent A. Orr et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

(2011) Katarzyna Bulek et al.   NATURE IMMUNOLOGY

I B kinase   and TANK-binding kinase 1 activate AKT by direct phosphorylation

(2011) X. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

(2010) Johanna K Sandling et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB

(2010) Hongyu Guan et al.   JOURNAL OF PATHOLOGY

Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer

(2009) Jian-Ping Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Over-expression of IκB-kinase-ε (IKKε/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines

(2009) Benjamin Péant et al.   PROSTATE

Synergistic benefit in inflammatory arthritis by targeting I B kinase   and interferon  

(2008) M Corr et al.   ANNALS OF THE RHEUMATIC DISEASES

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway

(2008) J. Zhang et al.   CANCER RESEARCH