H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism

(2020) Kenneth R. Olson et al.   MOLECULES

Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity

(2020) Shashank Shrishrimal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment

(2020) Taylor McElroy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses

(2020) Arpita Chatterjee et al.   Redox Biology

Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes

(2020) Ramya Ambur Sankaranarayanan et al.   Journal of Clinical Medicine

MnTE-2-PyP Suppresses Prostate Cancer Cell Growth via H2O2 Production

(2020) Yuxiang Zhu et al.   Antioxidants

Redox inhibition of Protein Phosphatase PP2A: potential implications in oncogenesis and its progression

(2019) Deepika Raman et al.   Redox Biology

MnTE-2-PyP Attenuates TGF-β-Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Inhibiting the Smad2/3 Signaling Pathway

(2019) Yu Yang et al.   Oxidative Medicine and Cellular Longevity

A Comprehensive Review of Ovarian Serous Carcinoma

(2019) Yuichiro Hatano et al.   ADVANCES IN ANATOMIC PATHOLOGY

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

(2019) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress

(2019) Xueqing Zhou et al.   Frontiers in Endocrinology

First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma

(2019) Bryan G. Allen et al.   CLINICAL CANCER RESEARCH

Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer

(2019) Carryn M. Anderson et al.   JOURNAL OF CLINICAL ONCOLOGY

MnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer

(2019) Anery Patel et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

25 years of development of Mn porphyrins — from mimics of superoxide dismutase enzymes to thiol signaling to clinical trials: The story of our life in the USA

(2019) Ines Batinic-Haberle et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Mn porphyrin-based redox-active drugs – Differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury

(2018) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

(2018) Artak Tovmasyan et al.   ANTIOXIDANTS & REDOX SIGNALING

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

(2018) Niraj Shenoy et al.   CANCER CELL

Mn porphyrin/ascorbate sensitizes serous epithelial ovarian cancer to chemotherapy

(2018) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues

(2018) Kranti A. Mapuskar et al.   SEMINARS IN RADIATION ONCOLOGY

Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue

(2018) Joshua D. Schoenfeld et al.   SEMINARS IN RADIATION ONCOLOGY

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP 5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

(2018) Wanda Anselmo et al.   Journal of the American Heart Association

The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells

(2018) Ana Flórido et al.   Redox Biology

Novel fluorinated Mn porphyrin as a powerful SOD mimic and catalyst for ascorbate-coupled anticancer therapy

(2017) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protection of rat prostate and erectile function from radiation-induced damage by novel Mn(III) N - substituted pyridylporphyrin and ascorbate

(2017) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular Fates of Manganese(II) Pentaazamacrocyclic Superoxide Dismutase (SOD) Mimetics: Fluorescently Labeled MnSOD Mimetics, X-ray Absorption Spectroscopy, and X-ray Fluorescence Microscopy Studies

(2017) Claire M. Weekley et al.   INORGANIC CHEMISTRY

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues

(2017) Zrinka Rajic et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Oxidative Stress Contributes to Status Epilepticus Associated Mortality

(2017) Jennifer N. Pearson-Smith et al.   NEUROCHEMICAL RESEARCH

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin

(2017) Samuel R. Birer et al.   RADIATION RESEARCH

MnTE-2-PyP Treatment, or NOX4 Inhibition, Protects against Radiation-Induced Damage in Mouse Primary Prostate Fibroblasts by Inhibiting the TGF-Beta 1 Signaling Pathway

(2017) Arpita Chatterjee et al.   RADIATION RESEARCH

PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production

(2017) Manutea Serrero et al.   Scientific Reports

A novel redox regulator, MnTnBuOE-2-PyP 5+ , enhances normal hematopoietic stem/progenitor cell function

(2017) Y. Zhao et al.   Redox Biology

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP 5+

(2017) David Leu et al.   Redox Biology

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III)n-butoxyethylpyridylporphyrin-based redox modifier

(2016) Douglas H. Weitzel et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP 5+ /Ascorbate System

(2016) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene

(2016) Qiang Tong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling

(2016) Sumitra Miriyala et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001)

(2016) Shayne Cox Gad et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells

(2016) Elizabeth A. Kosmacek et al.   Oncotarget

Anticancer therapeutic potential of Mn porphyrin/ascorbate system

(2015) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics

(2015) Artak Tovmasyan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comprehensive Study of GPx Activity of Different Classes of Redox-Active Therapeutics - Implications for Their Therapeutic Actions

(2015) Jacqueline C Bueno-Janice et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells

(2015) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynecologic oncology group study

(2015) Lisa M. Hess et al.   GYNECOLOGIC ONCOLOGY

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma

(2015) Sharareh Siamakpour-Reihani et al.   GYNECOLOGIC ONCOLOGY

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model

(2015) Kathleen A. Ashcraft et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Computational predictions of corroles as a class of Hsp90 inhibitors

(2015) Ruijie D. Teo et al.   Molecular BioSystems

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

(2015) Yulyana Yulyana et al.   Stem Cell Reviews and Reports

Impact of the SOD mimic MnTnHex-2-PyP on the adhesion and migration of doxorubicin-treated MDA-MB-231 cells

(2015) A. Flórido et al.   TOXICOLOGY LETTERS

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

(2015) Yulyana Yulyana et al.   Stem Cell Reviews and Reports

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H 2 O 2 -driven pathways

(2015) Ines Batinic-Haberle et al.   Redox Biology

Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects

(2014) Neera Tewari-Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin-Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

(2014) D. H. Weitzel et al.   MOLECULAR CANCER THERAPEUTICS

Nrf2, a Regulator of the Proteasome, Controls Self-Renewal and Pluripotency in Human Embryonic Stem Cells

(2014) Jiwon Jang et al.   STEM CELLS

Metalloporphyrins as Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders

(2013) Huaxin Sheng et al.   ANTIOXIDANTS & REDOX SIGNALING

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

(2013) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

(2013) J. L. Welsh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-PyP5+

(2013) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+

(2013) Tin Weitner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactivity and Cytoprotective Capacity of the Synthetic Catalytic Antioxidants Mnporphyrins towards Peroxynitrite and Hypochlorite

(2013) Sebastidn Carballal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

(2013) Myron K. Evans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential Coordination Demands in Fe versus Mn Water-Soluble Cationic Metalloporphyrins Translate into Remarkably Different Aqueous Redox Chemistry and Biology

(2013) Artak Tovmasyan et al.   INORGANIC CHEMISTRY

Recent Developments in Texaphyrin Chemistry and Drug Discovery

(2013) Christian Preihs et al.   INORGANIC CHEMISTRY

A Nonclinical Safety Assessment of MnTE-2-PyP, a Manganese Porphyrin

(2013) Shayne C. Gad et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II)N-Alkylpyridylporphyrins

(2013) Rima Ezzeddine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice

(2013) Karla M. Pires et al.   Obesity

Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance

(2013) Ling Xie et al.   Cell Reports

Superoxide dismutase mimic, MnTE-2-PyP5+ ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum

(2013) John O. Archambeau et al.   Redox Biology

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications

(2013) Dana K. Ali et al.   Redox Biology

Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution

(2012) Tin Weitner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese Porphyrin, MnTE-2-PyP5+, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells

(2012) Melba C. Jaramillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity

(2012) Zrinka Rajic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators

(2012) Artak Tovmasyan et al.   MEDICAL PRINCIPLES AND PRACTICE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Manganese superoxide dismutase, MnSOD and its mimics

(2011) Sumitra Miriyala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study

(2011) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression

(2011) Hongliang Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low-grade serous carcinomas of the ovary contain very few point mutations

(2011) Siân Jones et al.   JOURNAL OF PATHOLOGY

Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

(2011) H. Sheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amelioration of Renal Ischemia-Reperfusion Injury With a Novel Protective Cocktail

(2011) Thambi Dorai et al.   JOURNAL OF UROLOGY

NADPH oxidase inhibition attenuates total body irradiation-induced haematopoietic genomic instability

(2011) S. K. Pazhanisamy et al.   MUTAGENESIS

Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer

(2011) Robert A. Burger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

(2010) Ines Batinic-Haberle et al.   AMINO ACIDS

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

(2010) Ines Batinić-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox sensing: orthogonal control in cell cycle and apoptosis signalling

(2010) D. P. Jones   JOURNAL OF INTERNAL MEDICINE

Increased Manganese Superoxide Dismutase Expression or Treatment with Manganese Porphyrin Potentiates Dexamethasone-Induced Apoptosis in Lymphoma Cells

(2009) Melba C. Jaramillo et al.   CANCER RESEARCH

Microarray Analysis of Early Stage Serous Ovarian Cancers Shows Profiles Predictive of Favorable Outcome

(2009) A. Berchuck et al.   CLINICAL CANCER RESEARCH

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia–telangiectasia cells

(2009) Julianne M. Pollard et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat

(2009) Huaxin Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Welcome to ‘Fluorine in Medicinal Chemistry’

(2009) P Veeraraghavan Ramachandran   Future Medicinal Chemistry

Fluorinated molecules in the diagnosis and treatment of neurodegenerative diseases

(2009) Boyenoh Gaye et al.   Future Medicinal Chemistry

Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights

(2009) Robert Filler et al.   Future Medicinal Chemistry

Redox Regulation of the Human Dual Specificity Phosphatase YVH1 through Disulfide Bond Formation

(2009) Christopher A. Bonham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SOD-like activity of Mn(II) β-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

(2008) Gilson DeFreitas-Silva et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1  Induction via Superoxide

(2008) S. Kaewpila et al.   CANCER RESEARCH

Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP5+, in plasma and major organs of B6C3F1 mice

(2008) Ivan Spasojević et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy

(2008) Ines Batinić-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydroxamic acid and fluorinated derivatives of valproic acid: Anticonvulsant activity, neurotoxicity and teratogenicity

(2008) Ute Gravemann et al.   NEUROTOXICOLOGY AND TERATOLOGY

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA