Pt(iv) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

New insights into the molecular and epigenetic effects of antitumor Pt(IV)-valproic acid conjugates in human ovarian cancer cells

(2015) Vojtech Novohradsky et al.   BIOCHEMICAL PHARMACOLOGY

Cellular trafficking, accumulation and DNA platination of a series of cisplatin-based dicarboxylato Pt(IV) prodrugs

(2015) Mauro Ravera et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo

(2014) Nataly Tarasenko et al.   BIOCHEMICAL PHARMACOLOGY

Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands

(2014) Vojtech Novohradsky et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Novel Antitumor Cisplatin and Transplatin Derivatives Containing 1-Methyl-7-Azaindole: Synthesis, Characterization, and Cellular Responses

(2014) Jitka Pracharova et al.   JOURNAL OF MEDICINAL CHEMISTRY

A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies

(2013) Wei-Jan Huang et al.   CANCER LETTERS

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antiproliferative activity of Pt(IV)-bis(carboxylato) conjugates on malignant pleural mesothelioma cells

(2013) Manuela Alessio et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Combination therapy: Histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer

(2012) Himashinie V.K. Diyabalanage et al.   CANCER LETTERS

Facile Preparation of Mono-, Di- and Mixed-Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

(2012) Jenny Z. Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

What do we know about the reduction of Pt(IV) pro-drugs?

(2012) Ezequiel Wexselblatt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity

(2012) Verena Pichler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tuning the Activity of Platinum(IV) Anticancer Complexes through Asymmetric Acylation

(2012) Chee Fei Chin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Valuable Insight into the Anticancer Activity of the Platinum-Histone Deacetylase Inhibitor Conjugate, cis-[Pt(NH3)2malSAHA–2H)]

(2012) Viktor Brabec et al.   MOLECULAR PHARMACEUTICS

Conjugate of Pt(IV)–Histone Deacetylase Inhibitor as a Prodrug for Cancer Chemotherapy

(2012) Jun Yang et al.   MOLECULAR PHARMACEUTICS

Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21waf1/cip1-independent pathway in human colorectal cancer cells

(2011) Murugan Kalimutho et al.   ACTA PHARMACOLOGICA SINICA

Non-Classical Structures Among Current Platinum Complexes with Potential as Antitumor Drugs

(2011) Adoracion G. Quiroga   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Anticancer Platinum (IV) Prodrugs with Novel Modes of Activity

(2011) Chee Fei Chin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells

(2011) Ke Long Jin et al.   Journal of Gynecologic Oncology

Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity

(2011) Darren M. Griffith et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Phenylbutyrate inhibits homologous recombination induced by camptothecin and methyl methanesulfonate

(2011) Gitte S. Kaiser et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

(2010) Daniel M. Fass et al.   ACS Medicinal Chemistry Letters

A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity

(2009) Darren Griffith et al.   CHEMICAL COMMUNICATIONS

Status of Non-Classical Mononuclear Platinum Anticancer Drug Development

(2009) Jinchao Zhang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Histone deacetylase inhibitors in cancer therapy

(2008) Min-Jung Lee et al.   CURRENT OPINION IN ONCOLOGY

Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin

(2008) Kyunghee Burkitt et al.   Molecular Cancer