RNA-Binding Proteins: A Role in Neurotoxicity?

Downregulation of NUDT21 contributes to cervical cancer progression through alternative polyadenylation

(2021) Yifei Xing et al.   ONCOGENE

The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex

(2021) Rebecca M. Sena et al.   MOLECULES

Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health

(2021) Yunqi Chao et al.   Cell and Bioscience

The role of CPEB family proteins in the nervous system function in the norm and pathology

(2021) Eugene Kozlov et al.   Cell and Bioscience

The involvement of stress granules in aging and aging‐associated diseases

(2020) Xiuling Cao et al.   AGING CELL

The emerging role of RNA modifications in the regulation of mRNA stability

(2020) Sung Ho Boo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

(2020) Jack Humphrey et al.   NUCLEIC ACIDS RESEARCH

FUS P525L mutation causing amyotrophic lateral sclerosis and movement disorders

(2020) Binbin Zhou et al.   Brain and Behavior

The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

(2020) Alexander Bampton et al.   ACTA NEUROPATHOLOGICA

A large-scale binding and functional map of human RNA-binding proteins

(2020) Eric L. Van Nostrand et al.   NATURE

The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies

(2020) Myungjin Jo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

STAU1 selectively regulates the expression of inflammatory and immune response genes and alternative splicing of the nerve growth factor receptor signaling pathway

(2020) Yi Zhong et al.   ONCOLOGY REPORTS

RNA-binding proteins balance brain function in health and disease

(2020) Rico Schieweck et al.   PHYSIOLOGICAL REVIEWS

Molecular mechanisms behind mRNA localization in axons

(2020) Benita Turner-Bridger et al.   Open Biology

Molecular mechanisms of stress granule assembly and disassembly

(2020) Sarah Hofmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RBPsuite: RNA-protein binding sites prediction suite based on deep learning

(2020) Xiaoyong Pan et al.   BMC GENOMICS

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

(2019) Alexandros Poulopoulos et al.   NATURE

Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS

(2019) Sarah Y. Ebstein et al.   Cell Reports

Molecular Mechanisms of Synaptic Dysregulation in Fragile X Syndrome and Autism Spectrum Disorders

(2019) Michael Telias   Frontiers in Molecular Neuroscience

Post-translational modification control of RNA-binding protein hnRNPK function

(2019) Yongjie Xu et al.   Open Biology

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

(2019) Jacob R. Mann et al.   NEURON

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

(2019) Manuel Garcia-Moreno et al.   MOLECULAR CELL

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

(2019) Stephen Moore et al.   ACTA NEUROPATHOLOGICA

The emerging roles of hnRNPK

(2019) Ziyi Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The potential of engineered eukaryotic RNA‐binding proteins as molecular tools and therapeutics

(2019) Carl R. Shotwell et al.   Wiley Interdisciplinary Reviews-RNA

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

(2018) Jade-Emmanuelle Deshaies et al.   BRAIN

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Joining the dots - protein-RNA interactions mediating local mRNA translation in neurons

(2018) Christopher Gallagher et al.   FEBS LETTERS

Locally translated mTOR controls axonal local translation in nerve injury

(2018) Marco Terenzio et al.   SCIENCE

Quality control of mRNAs at the entry of the nuclear pore: Cooperation in a complex molecular system

(2018) Mohammad Soheilypour et al.   Nucleus

Quality control of mRNAs at the entry of the nuclear pore: Cooperation in a complex molecular system

(2018) Mohammad Soheilypour et al.   Nucleus

Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain

(2018) Yi-Mei Yang et al.   MOLECULAR PSYCHIATRY

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

(2018) Alberto Parras et al.   NATURE

RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis

(2018) Kat S. Moore et al.   Frontiers in Physiology

RBP-Maps enables robust generation of splicing regulatory maps

(2018) Brian A. Yee et al.   RNA

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

(2018) Aaron C. Goldstrohm et al.   TRENDS IN GENETICS

RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae

(2017) Camila Oliveira et al.   GENETICS AND MOLECULAR BIOLOGY

Genetic mutations in RNA-binding proteins and their roles in ALS

(2017) Katannya Kapeli et al.   HUMAN GENETICS

Hu antigen R (HuR) multimerization contributes to glioma disease progression

(2017) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

(2017) Daniel J. Apicco et al.   NATURE NEUROSCIENCE

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

(2017) Marta M. Fay et al.   Cell Reports

Genetics of Amyotrophic Lateral Sclerosis

(2017) Mehdi Ghasemi et al.   Cold Spring Harbor Perspectives in Medicine

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

(2017) Barbara Celona et al.   eLife

Ataxin-2: From RNA Control to Human Health and Disease

(2017) Lauren Ostrowski et al.   Genes

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

RNA-binding proteins, neural development and the addictions

(2016) C. D. Bryant et al.   GENES BRAIN AND BEHAVIOR

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

Dysregulation of mRNA Localization and Translation in Genetic Disease

(2016) Eric T. Wang et al.   JOURNAL OF NEUROSCIENCE

The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions

(2016) Benedikt M. Beckmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hypo- and Hyper-Assembly Diseases of RNA–Protein Complexes

(2016) Siddharth Shukla et al.   TRENDS IN MOLECULAR MEDICINE

TIA-1 Is a Functional Prion-Like Protein

(2016) Joseph B. Rayman et al.   Cold Spring Harbor Perspectives in Biology

Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier

(2016) Emma Bondy-Chorney et al.   PLoS Genetics

Neurodegeneration and RNA-binding proteins

(2016) Laura De Conti et al.   Wiley Interdisciplinary Reviews-RNA

Posttranslational control of HuR function

(2016) Ioannis Grammatikakis et al.   Wiley Interdisciplinary Reviews-RNA

Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development

(2016) Nanako Hamada et al.   Scientific Reports

The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion

(2015) Guramrit Singh et al.   Annual Review of Biochemistry

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Position-specific binding of FUS to nascent RNA regulates mRNA length

(2015) Akio Masuda et al.   GENES & DEVELOPMENT

Specific interaction of KIF11 with ZBP1 regulates the transport of  -actin mRNA and cell motility

(2015) T. Song et al.   JOURNAL OF CELL SCIENCE

Specificity and nonspecificity in RNA–protein interactions

(2015) Eckhard Jankowsky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

(2015) Bushra Raj et al.   NEURON

Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing

(2015) Saravana P. Selvanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles of Disordered Sequences in RNA-Binding Proteins

(2015) Sara Calabretta et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain

(2015) Louis-Jan Pilaz et al.   Wiley Interdisciplinary Reviews-RNA

Cytoplasmic Polyadenylation Element Binding Proteins in Development, Health, and Disease

(2014) Maria Ivshina et al.   Annual Review of Cell and Developmental Biology

Remote Control of Gene Function by Local Translation

(2014) Hosung Jung et al.   CELL

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

(2014) Ranjan Batra et al.   MOLECULAR CELL

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

(2014) Iren Wang et al.   NUCLEIC ACIDS RESEARCH

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

(2014) P.-H. Kuo et al.   NUCLEIC ACIDS RESEARCH

RNA-binding proteins in neurological diseases

(2014) HuaLin Zhou et al.   Science China-Life Sciences

Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience

(2014) Joshua A. Ainsley et al.   Nature Communications

The RBPome: where the brains meet the brawn

(2014) Naomi Attar   GENOME BIOLOGY

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells

(2014) Sophie Martin et al.   Jove-Journal of Visualized Experiments

PABPN1: molecular function and muscle disease

(2013) Ayan Banerjee et al.   FEBS Journal

Role of Stress Granules and RNA-Binding Proteins in Neurodegeneration: A Mini-Review

(2013) Tara Vanderweyde et al.   GERONTOLOGY

U1A Regulates 3′ Processing of the Survival Motor Neuron mRNA

(2013) Eileen Workman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The function of the RNA-binding protein hnRNP in cancer metastasis

(2013) Mengxian Zhang et al.   Journal of Cancer Research and Therapeutics

Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice

(2013) Jonathan Janssens et al.   MOLECULAR NEUROBIOLOGY

Cytoplasmic RNA: a case of the tail wagging the dog

(2013) Chris J. Norbury   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

(2012) Matthew Brook et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Translational control by 3'-UTR-binding proteins

(2012) E. Szostak et al.   Briefings in Functional Genomics

High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity

(2012) Sang Hwa Kim et al.   HUMAN MOLECULAR GENETICS

Translation of the cell adhesion molecule ALCAM in axonal growth cones – regulation and functional importance

(2012) Karsten Thelen et al.   JOURNAL OF CELL SCIENCE

Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability

(2012) Gulayse Ince-Dunn et al.   NEURON

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells.

(2012) Eva Matoulkova et al.   RNA Biology

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Pre-mRNA splicing in disease and therapeutics

(2012) Ravi K. Singh et al.   TRENDS IN MOLECULAR MEDICINE

Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function

(2012) J. C. Darnell et al.   Cold Spring Harbor Perspectives in Biology

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges

(2012) A. G. Hinnebusch et al.   Cold Spring Harbor Perspectives in Biology

Translational control mechanisms in metabolic regulation: critical role of RNA binding proteins, microRNAs, and cytoplasmic RNA granules

(2011) Khosrow Adeli   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulatory Roles of Heterogeneous Nuclear Ribonucleoprotein M and Nova-1 Protein in Alternative Splicing of Dopamine D2 Receptor Pre-mRNA

(2011) Eonyoung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Low-Complexity Sequences in the Formation of Novel Protein Coding Sequences

(2011) M. Toll-Riera et al.   MOLECULAR BIOLOGY AND EVOLUTION

A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)

(2011) R. A. Armstrong et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Implications of the prion-related Q/N domains in TDP-43 and FUS

(2011) Maria Udan et al.   Prion

Myotonic Dystrophies 1 and 2: Complex Diseases with Complex Mechanisms

(2010) Benedikt Schoser et al.   CURRENT GENOMICS

Neurotoxic effects of TDP-43 overexpression in C. elegans

(2010) Peter E.A. Ash et al.   HUMAN MOLECULAR GENETICS

Identification of a self-association domain in the Ewing's sarcoma protein: a novel function for arginine-glycine-glycine rich motifs?

(2010) D. J. Shaw et al.   JOURNAL OF BIOCHEMISTRY

Ubiquilin Modifies TDP-43 Toxicity in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

(2010) Keith A. Hanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

mRNA Localization: Gene Expression in the Spatial Dimension

(2009) Kelsey C. Martin et al.   CELL

Depletion of TDP-43 affectsDrosophila motoneuronsterminal synapsis and locomotive behavior

(2009) Fabian Feiguin et al.   FEBS LETTERS

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

(2009) G. S. Pesiridis et al.   HUMAN MOLECULAR GENETICS

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

RNA granules: post-transcriptional and epigenetic modulators of gene expression

(2009) Paul Anderson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

(2008) Jason B. Dictenberg et al.   DEVELOPMENTAL CELL

Structure and function of KH domains

(2008) Roberto Valverde et al.   FEBS Journal

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

(2008) Donny D. Licatalosi et al.   NATURE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

RNA-binding proteins in human genetic disease

(2008) Kiven E. Lukong et al.   TRENDS IN GENETICS

Developmental expression profile ofquaking, a candidate gene for schizophrenia, and its target genes in human prefrontal cortex and hippocampus shows regional specificity

(2007) Tara L. Lauriat et al.   JOURNAL OF NEUROSCIENCE RESEARCH