The hnRNP family: insights into their role in health and disease

Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

(2016) Xianxun Liu et al.   GENE

hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation

(2016) Kathryn R. Williams et al.   MOLECULAR BIOLOGY OF THE CELL

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

(2015) Johnathan Cooper-Knock et al.   ACTA NEUROPATHOLOGICA

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells

(2015) So Jung Park et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nanoparticle-conjugated aptamer targeting hnRNP A2/B1 can recognize multiple tumor cells and inhibit their proliferation

(2015) Hui Li et al.   BIOMATERIALS

hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies

(2015) Miguel Gallardo et al.   CANCER CELL

TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor

(2015) Fatemeh Mohagheghi et al.   HUMAN MOLECULAR GENETICS

Heterogeneous ribonucleoprotein R regulates arylalkylamine N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner

(2015) Hwa-Rim Lee et al.   JOURNAL OF PINEAL RESEARCH

Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease

(2015) Antonella Borreca et al.   MOLECULAR NEUROBIOLOGY

CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer

(2015) TIING JEN LOH et al.   ONCOLOGY REPORTS

SRSF3 and hnRNP H1 regulate a splicing hotspot ofHER2in breast cancer cells

(2015) Hannah Gautrey et al.   RNA Biology

Evidence for cooperative tandem binding of hnRNP C RRMs in mRNA processing

(2015) Zuzana Cieniková et al.   RNA

Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer

(2015) XIAO-HAN QU et al.   Oncology Letters

Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation

(2015) Xiaoqin Fan et al.   Scientific Reports

DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability

(2014) Cong Ren et al.   BIOCHEMICAL JOURNAL

hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7

(2014) Sunghee Cho et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

(2014) Y. Xu et al.   GENES & DEVELOPMENT

Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons

(2014) Ilham A. Muslimov et al.   JOURNAL OF CELL BIOLOGY

Antisense Oligonucleotide Therapy for the Treatment of C9ORF72 ALS/FTD Diseases

(2014) Giulietta Riboldi et al.   MOLECULAR NEUROBIOLOGY

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

(2014) Ahmed Moursy et al.   NUCLEIC ACIDS RESEARCH

Presynaptic Localization of Smn and hnRNP R in Axon Terminals of Embryonic and Postnatal Mouse Motoneurons

(2014) Benjamin Dombert et al.   PLoS One

Cerebrospinal Fluid Extracellular Vesicles Undergo Age Dependent Declines and Contain Known and Novel Non-coding RNAs

(2014) Ashlee Tietje et al.   PLoS One

Crosslinking-immunoprecipitation (iCLIP) analysis reveals global regulatory roles of hnRNP L

(2014) Oliver Rossbach et al.   RNA Biology

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Regulation of mRNA Abundance by Polypyrimidine Tract-Binding Protein-Controlled Alternate 5′ Splice Site Choice

(2014) Fursham M. Hamid et al.   PLoS Genetics

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

(2013) Kohji Mori et al.   ACTA NEUROPATHOLOGICA

H19 inhibits RNA polymerase II-mediated transcription by disrupting the hnRNP U–actin complex

(2013) Hai-shan Bi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antisense Oligonucleotides for the Treatment of Spinal Muscular Atrophy

(2013) Paul N. Porensky et al.   HUMAN GENE THERAPY

hnRNP A1: The Swiss Army Knife of Gene Expression

(2013) Jacques Jean-Philippe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L

(2013) Ngoc T. Vu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures and RNA-binding Properties of the RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein L

(2013) Wenjuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-Terminal Kinase Phosphorylation of Heterogeneous Nuclear Ribonucleoprotein K Regulates Vertebrate Axon Outgrowth via a Posttranscriptional Mechanism

(2013) E. J. Hutchins et al.   JOURNAL OF NEUROSCIENCE

 CP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation

(2013) X. Ji et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

hnRNPA2B1 and hnRNPA1 mutations are rare in patients with “multisystem proteinopathy” and frontotemporal lobar degeneration phenotypes

(2013) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

Prediction of clustered RNA-binding protein motif sites in the mammalian genome

(2013) Chaolin Zhang et al.   NUCLEIC ACIDS RESEARCH

Requirement of Heterogeneous Nuclear Ribonucleoprotein C for BRCA Gene Expression and Homologous Recombination

(2013) Rachel W. Anantha et al.   PLoS One

Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability

(2013) Seong-Jun Cho et al.   PLoS One

Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK

(2013) Y. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA

(2013) Mohammad Alinoor Rahman et al.   Scientific Reports

Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

(2013) Youn-Bok Lee et al.   Cell Reports

Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q

(2013) Yuri V. Svitkin et al.   PLOS BIOLOGY

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

(2012) Hitomi Tsuiji et al.   EMBO Molecular Medicine

THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line

(2012) Wen-Xi Lian et al.   FEBS LETTERS

Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: From structural insights to post-transcriptional regulatory roles

(2012) Uriya Bekenstein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis

(2012) Lei Xing et al.   MOLECULAR BIOLOGY OF THE CELL

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation

(2012) Wenguang Cao et al.   NUCLEIC ACIDS RESEARCH

The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA

(2012) Brighton Samatanga et al.   NUCLEIC ACIDS RESEARCH

Polypyrimidine Tract Binding Protein (hnRNP I) Is Possibly a Conserved Modulator of miRNA-Mediated Gene Regulation

(2012) Bart Engels et al.   PLoS One

hnRNP C Tetramer Measures RNA Length to Classify RNA Polymerase II Transcripts for Export

(2012) A. McCloskey et al.   SCIENCE

Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

(2012) Charles Pin-Kuang Lai et al.   Frontiers in Physiology

hnRNP K post-transcriptionally co-regulates multiple cytoskeletal genes needed for axonogenesis

(2011) Y. Liu et al.   DEVELOPMENT

Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L

(2011) Faegheh Jafarifar et al.   EMBO JOURNAL

An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5′ splice site of tau exon 10, whose misregulation causes frontotemporal dementia

(2011) Yan Wang et al.   GENE

Regulatory Roles of Heterogeneous Nuclear Ribonucleoprotein M and Nova-1 Protein in Alternative Splicing of Dopamine D2 Receptor Pre-mRNA

(2011) Eonyoung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Control of Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms by the Heterogeneous Nuclear Ribonuclear Proteins hnRNP L, hnRNP A1, and hnRNP M

(2011) Kenneth J. Dery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step

(2011) George S. Hussey et al.   MOLECULAR CELL

Functional diversity of the hnRNPs: past, present and perspectives

(2010) Siew Ping Han et al.   BIOCHEMICAL JOURNAL

Telomeric DNA-binding activities of heterogeneous nuclear ribonucleoprotein A3 in vitro and in vivo

(2010) Pei-Rong Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

(2010) Yuko Hasegawa et al.   DEVELOPMENTAL CELL

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice

(2010) David Llères et al.   EMBO REPORTS

PCBP-1 regulates alternative splicing of the CD44 gene and inhibits invasion in human hepatoma cell line HepG2 cells

(2010) Tong Zhang et al.   Molecular Cancer

Context-Dependent Regulatory Mechanism of the Splicing Factor hnRNP L

(2010) Laura B. Motta-Mena et al.   MOLECULAR CELL

TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI

(2010) Arindam Chaudhury et al.   NATURE CELL BIOLOGY

Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs

(2010) Cyril Dominguez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

(2010) Eun Kyung Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel missense and truncating mutations in FUS/TLS in familial ALS

(2010) S. Waibel et al.   NEUROLOGY

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles

(2010) A. Chaudhury et al.   RNA

TERRA transcripts are bound by a complex array of RNA-binding proteins

(2010) Isabel López de Silanes et al.   Nature Communications

hnRNP M interacts with PSF and p54nrb and co-localizes within defined nuclear structures

(2009) Marija Marko et al.   EXPERIMENTAL CELL RESEARCH

hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions

(2009) Toshiyuki Fukuda et al.   GENES TO CELLS

Heterogeneous Nuclear Ribonucleoprotein R Enhances Transcription from the Naturally Configured c-fosPromoterin Vitro

(2009) Aya Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Heterogeneous Nuclear Ribonucleoprotein-recognition Region in the HIV Rev Protein

(2009) Kamyar Hadian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of the Poly(C)-binding Proteins αCP1 and αCP2 from K562 Cells Leads to p53-independent Induction of Cyclin-dependent Kinase Inhibitor (CDKN1A) and G1Arrest

(2009) Shelly A. Waggoner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hnRNA-Binding Proteins hnRNP L and PTB Are Required for Efficient Translation of the Cat-1 Arginine/Lysine Transporter mRNA during Amino Acid Starvation

(2009) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

The Germ Cell Nuclear Proteins hnRNP G-T and RBMY Activate a Testis-Specific Exon

(2009) Yilei Liu et al.   PLoS Genetics

A crucial role for hnRNP K in axon development in Xenopus laevis

(2008) Y. Liu et al.   DEVELOPMENT

mRNA Silencing in Human Erythroid Cell Maturation

(2008) Isabel S. Naarmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteomics Approach for Identification of Single Strand DNA-binding Proteins Involved in Transcriptional Regulation of Mouse μ Opioid Receptor Gene

(2008) Hack Sun Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene

(2008) H.-H. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Multiplexed Dendritic Targeting of α Calcium Calmodulin-dependent Protein Kinase II, Neurogranin, and Activity-regulated Cytoskeleton-associated Protein RNAs by the A2 Pathway

(2008) Yuanzheng Gao et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic endogenous association of neurofilament mRNAs with K-homology domain ribonucleoproteins in developing cerebral cortex

(2007) Amar Thyagarajan et al.   BRAIN RESEARCH