The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
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Title
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
Authors
Keywords
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Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-10-13
DOI
10.1038/s12276-020-00513-7
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Related references
Note: Only part of the references are listed.- TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
- (2020) Lumi Zhang et al. Frontiers in Aging Neuroscience
- TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
- (2020) Wendi Huang et al. Frontiers in Molecular Neuroscience
- Protein transmission in neurodegenerative disease
- (2020) Chao Peng et al. Nature Reviews Neurology
- Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death
- (2019) Fatima Gasset-Rosa et al. NEURON
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
- (2019) Peter T Nelson et al. BRAIN
- Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
- (2019) Sneham Tiwari et al. International Journal of Nanomedicine
- Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis
- (2019) Luke McAlary et al. Frontiers in Molecular Neuroscience
- Assessing the Limitations and Biases in the Current Understanding of Chronic Traumatic Encephalopathy
- (2018) Nicole Schwab et al. JOURNAL OF ALZHEIMERS DISEASE
- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- RNA buffers the phase separation behavior of prion-like RNA binding proteins
- (2018) Shovamayee Maharana et al. SCIENCE
- TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease
- (2018) Sukriti Nag et al. Acta Neuropathologica Communications
- Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
- (2018) Mathias Jucker et al. NATURE NEUROSCIENCE
- Biomarkers for diseases with TDP-43 pathology
- (2018) Petra Steinacker et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates
- (2018) Florent Laferrière et al. NATURE NEUROSCIENCE
- Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
- (2018) Sílvia Porta et al. Nature Communications
- Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
- (2017) Matthew D. Cykowski et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD
- (2017) Sukriti Nag et al. NEUROLOGY
- Flow cytometric measurement of the cellular propagation of TDP-43 aggregation
- (2017) Rafaa Zeineddine et al. Prion
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
- (2017) Mauricio Budini et al. Frontiers in Molecular Neuroscience
- Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
- (2017) Sivan Peled et al. Scientific Reports
- Updated TDP-43 in Alzheimer’s disease staging scheme
- (2016) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- Exosome secretion is a key pathway for clearance of pathological TDP-43
- (2016) Yohei Iguchi et al. BRAIN
- Alpha-Synuclein as a Biomarker for Parkinson's Disease
- (2016) Anzari Atik et al. BRAIN PATHOLOGY
- The TDP-43 N-terminal domain structure at high resolution
- (2016) Miguel Mompeán et al. FEBS Journal
- The hnRNP family: insights into their role in health and disease
- (2016) Thomas Geuens et al. HUMAN GENETICS
- In vitro prion-like behaviour of TDP-43 in ALS
- (2016) Phillip Smethurst et al. NEUROBIOLOGY OF DISEASE
- TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion
- (2016) Edward Pokrishevsky et al. Scientific Reports
- TDP-43 is intercellularly transmitted across axon terminals
- (2015) Marisa S. Feiler et al. JOURNAL OF CELL BIOLOGY
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons
- (2015) R. Mutihac et al. NEUROBIOLOGY OF DISEASE
- Erratum to: TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets
- (2015) Emma L. Scotter et al. Neurotherapeutics
- Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure
- (2015) Xuebing Ding et al. Oncotarget
- Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
- (2014) Johannes Brettschneider et al. ACTA NEUROPATHOLOGICA
- TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
- (2014) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord
- (2014) Johannes Brettschneider et al. ACTA NEUROPATHOLOGICA
- Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD
- (2014) Michael E. Ward et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor
- (2014) L. Liu-Yesucevitz et al. JOURNAL OF NEUROSCIENCE
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- The phenotypic variability of amyotrophic lateral sclerosis
- (2014) Bart Swinnen et al. Nature Reviews Neurology
- The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity
- (2014) Chia-Sui Sun et al. PLoS One
- Staging TDP-43 pathology in Alzheimer’s disease
- (2013) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
- (2013) Johannes Brettschneider et al. ANNALS OF NEUROLOGY
- Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
- (2013) Jianbin Tong et al. EMBO JOURNAL
- Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones
- (2013) Maria Udan-Johns et al. HUMAN MOLECULAR GENETICS
- Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
- (2013) Mathias Jucker et al. NATURE
- Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
- (2013) Heiko Braak et al. Nature Reviews Neurology
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
- (2013) Takashi Nonaka et al. Cell Reports
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity
- (2012) Chung-ke Chang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Prions in Yeast
- (2012) S. W. Liebman et al. GENETICS
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- A harmonized classification system for FTLD-TDP pathology
- (2011) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
- (2011) Weirui Guo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
- (2010) Agnes L. Nishimura et al. BRAIN
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- Seeded Aggregation and Toxicity of α-Synuclein and Tau
- (2010) Takashi Nonaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
- (2010) C. M. Dewey et al. MOLECULAR AND CELLULAR BIOLOGY
- Cell-to-cell transmission of non-prion protein aggregates
- (2010) Seung-Jae Lee et al. Nature Reviews Neurology
- Clinical staging and disease progression in frontotemporal dementia
- (2010) E. Mioshi et al. NEUROLOGY
- Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis
- (2010) Ruth Chia et al. PLoS One
- Peripherally Applied A -Containing Inoculates Induce Cerebral -Amyloidosis
- (2010) Y. S. Eisele et al. SCIENCE
- Clinical and Pathological Continuum of Multisystem TDP-43 Proteinopathies
- (2009) Felix Geser et al. ARCHIVES OF NEUROLOGY
- Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
- (2009) Takashi Nonaka et al. HUMAN MOLECULAR GENETICS
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Prions hijack tunnelling nanotubes for intercellular spread
- (2009) Karine Gousset et al. NATURE CELL BIOLOGY
- The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion
- (2009) Basant K. Patel et al. NATURE CELL BIOLOGY
- ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration
- (2009) J. M. Ravits et al. NEUROLOGY
- The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids
- (2009) Adriano Aguzzi et al. NEURON
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions
- (2009) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
- (2008) Yuki Inukai et al. FEBS LETTERS
- A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro
- (2008) Matthew J. Winton et al. FEBS LETTERS
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia
- (2008) C C Weihl et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies
- (2008) Kunihiro Uryu et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
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