Joining the dots - protein-RNA interactions mediating local mRNA translation in neurons

Molecular control of local translation in axon development and maintenance

(2018) Jean-Michel Cioni et al.   CURRENT OPINION IN NEUROBIOLOGY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Staufen2 deficiency leads to impaired response to novelty in mice

(2018) Bastian Popper et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification

(2018) Siraj K. Zahr et al.   NEURON

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets

(2018) Fruzsina Hobor et al.   Nature Communications

The alternative life of RNA-sequencing meets single molecule approaches

(2017) Sandra M. Fernández-Moya et al.   FEBS LETTERS

mRNA localization in metazoans: A structural perspective

(2017) Daniela Lazzaretti et al.   RNA Biology

RNA localization is a key determinant of neurite-enriched proteome

(2017) Alessandra Zappulo et al.   Nature Communications

Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA

(2017) Raúl Ortiz et al.   Cell Reports

Mechanism of β-actin mRNA Recognition by ZBP1

(2017) Giuseppe Nicastro et al.   Cell Reports

RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

(2017) Kei Nakayama et al.   eLife

ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons

(2017) Anna S. Urbanska et al.   Scientific Reports

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

The new (dis)order in RNA regulation

(2016) Aino I. Järvelin et al.   Cell Communication and Signaling

De-coding and re-coding RNA recognition by PUF and PPR repeat proteins

(2016) Traci M Tanaka Hall   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dysregulation of mRNA Localization and Translation in Genetic Disease

(2016) Eric T. Wang et al.   JOURNAL OF NEUROSCIENCE

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Distal Alternative Last Exons Localize mRNAs to Neural Projections

(2016) J. Matthew Taliaferro et al.   MOLECULAR CELL

RNA-binding profiles ofDrosophilaCPEB proteins Orb and Orb2

(2016) Barbara Krystyna Stepien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation dynamics of single mRNAs in live cells and neurons

(2016) B. Wu et al.   SCIENCE

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

(2016) Anne E. Conway et al.   Cell Reports

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

(2016) Chase A Weidmann et al.   eLife

Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology

(2015) Janosch Hennig et al.   BIOESSAYS

Quantifying Protein-mRNA Interactions in Single Live Cells

(2015) Bin Wu et al.   CELL

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Specific interaction of KIF11 with ZBP1 regulates the transport of  -actin mRNA and cell motility

(2015) T. Song et al.   JOURNAL OF CELL SCIENCE

Fragile X mental retardation protein interactions with a G quadruplex structure in the 3′-untranslated region of NR2B mRNA

(2015) Snezana Stefanovic et al.   Molecular BioSystems

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1

(2015) Yoichiro Sugimoto et al.   NATURE

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

The FMRP/GRK4mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum

(2015) Thomas Maurin et al.   NUCLEIC ACIDS RESEARCH

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially resolved, highly multiplexed RNA profiling in single cells

(2015) K. H. Chen et al.   SCIENCE

Probing RNA–protein networks: biochemistry meets genomics

(2015) Zachary T. Campbell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model

(2015) Weirui Guo et al.   Cell Reports

The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation

(2015) Inga Loedige et al.   Cell Reports

FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA

(2015) Yang Zhang et al.   RNA Biology

Cytoplasmic Polyadenylation Element Binding Proteins in Development, Health, and Disease

(2014) Maria Ivshina et al.   Annual Review of Cell and Developmental Biology

Remote Control of Gene Function by Local Translation

(2014) Hosung Jung et al.   CELL

A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins

(2014) T. Afroz et al.   GENES & DEVELOPMENT

The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation

(2014) I. Loedige et al.   GENES & DEVELOPMENT

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain

(2014) Leila K. Myrick et al.   HUMAN MOLECULAR GENETICS

Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology

(2014) Teresa Carlomagno   JOURNAL OF MAGNETIC RESONANCE

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

(2014) Eileen Chen et al.   MOLECULAR CELL

Structural basis for the assembly of the Sxl–Unr translation regulatory complex

(2014) Janosch Hennig et al.   NATURE

In the right place at the right time: visualizing and understanding mRNA localization

(2014) Adina R. Buxbaum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single  -Actin mRNA Detection in Neurons Reveals a Mechanism for Regulating Its Translatability

(2014) A. R. Buxbaum et al.   SCIENCE

‘Black sheep’ that don’t leave the double-stranded RNA-binding domain fold

(2014) Michael L. Gleghorn et al.   TRENDS IN BIOCHEMICAL SCIENCES

The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity

(2014) Jacki E. Heraud-Farlow et al.   TRENDS IN NEUROSCIENCES

Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience

(2014) Joshua A. Ainsley et al.   Nature Communications

GraphProt: modeling binding preferences of RNA-binding proteins

(2014) Daniel Maticzka et al.   GENOME BIOLOGY

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains

(2013) Kristin Wächter et al.   BIOLOGICAL CHEMISTRY

Widespread and extensive lengthening of 3' UTRs in the mammalian brain

(2013) P. Miura et al.   GENOME RESEARCH

Defining the RGG/RG Motif

(2013) Palaniraja Thandapani et al.   MOLECULAR CELL

An Asymmetrically Localized Staufen2-Dependent RNA Complex Regulates Maintenance of Mammalian Neural Stem Cells

(2012) John P. Vessey et al.   Cell Stem Cell

Dynamics in multi-domain protein recognition of RNA

(2012) Cameron D Mackereth et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RRM–RNA recognition: NMR or crystallography…and new findings

(2012) Gerrit M Daubner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Principles and roles of mRNA localization in animal development

(2012) C. Medioni et al.   DEVELOPMENT

RNA-binding proteins involved in RNA localization and their implications in neuronal diseases

(2012) Marco Tolino et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

(2012) V. L. Patel et al.   GENES & DEVELOPMENT

The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons

(2012) Krishna H. Zivraj et al.   JOURNAL OF NEUROCHEMISTRY

Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis

(2012) Giuseppe Nicastro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Dendritic protein synthesis in the normal and diseased brain

(2012) S.A. Swanger et al.   NEUROSCIENCE

KH domains with impaired nucleic acid binding as a tool for functional analysis

(2012) David Hollingworth et al.   NUCLEIC ACIDS RESEARCH

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Brat Promotes Stem Cell Differentiation via Control of a Bistable Switch that Restricts BMP Signaling

(2011) Robin E. Harris et al.   DEVELOPMENTAL CELL

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

(2011) Michael Doyle et al.   EMBO JOURNAL

In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation

(2011) R. L. Coffee et al.   HUMAN MOLECULAR GENETICS

Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA

(2011) Cuong D. Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Netrin-1-Induced Local  -Actin Synthesis and Growth Cone Guidance Requires Zipcode Binding Protein 1

(2011) K. Welshhans et al.   JOURNAL OF NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28

(2011) Fionna E Loughlin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

(2011) Anh Tuân Phan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove

(2010) Richard Stefl et al.   CELL

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

ZBP1 recognition of  -actin zipcode induces RNA looping

(2010) J. A. Chao et al.   GENES & DEVELOPMENT

The E3-ubiquitin ligase TRIM2 regulates neuronal polarization

(2010) Mohammad R. Khazaei et al.   JOURNAL OF NEUROCHEMISTRY

Molecular basis of FIR-mediated c-myc transcriptional control

(2010) Cyprian D Cukier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

(2010) D.-I. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA processing and its regulation: global insights into biological networks

(2009) Donny D. Licatalosi et al.   NATURE REVIEWS GENETICS

Systematic analysis of posttranscriptional gene expression

(2009) Adam R. Morris et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

(2008) I.-Fan Wang et al.   JOURNAL OF NEUROCHEMISTRY

Translational control of localized mRNAs: restricting protein synthesis in space and time

(2008) Florence Besse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA

(2008) L. Menon et al.   RNA