Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing

RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1

(2015) Hayriye Verda Erkizan et al.   NUCLEIC ACIDS RESEARCH

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

(2015) Julie S. Barber-Rotenberg et al.   Oncotarget

N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

(2014) Brandon E. Aubol et al.   BIOCHEMICAL JOURNAL

The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response

(2014) Xu Cao et al.   BMC BIOCHEMISTRY

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

(2014) A. S. Adler et al.   GENES & DEVELOPMENT

Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications

(2014) A. Veloso et al.   GENOME RESEARCH

Transcriptional outcome of telomere signalling

(2014) Jing Ye et al.   NATURE REVIEWS GENETICS

Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein

(2014) Maria Paola Paronetto et al.   Cell Reports

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Feedback regulation of telomerase reverse transcriptase: new insight into the evolving field of telomerase in cancer

(2013) Xiao-qin Wu et al.   CELLULAR SIGNALLING

A Multifunctional Protein, EWS, Is Essential for Early Brown Fat Lineage Determination

(2013) Jun Hong Park et al.   DEVELOPMENTAL CELL

Partitioning RS Domain Phosphorylation in an SR Protein through the CLK and SRPK Protein Kinases

(2013) Brandon E. Aubol et al.   JOURNAL OF MOLECULAR BIOLOGY

Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA

(2013) Michelle T. Paulsen et al.   METHODS

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

(2013) Mandy S. Wong et al.   Cell Reports

Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

(2012) Richard B. Womer et al.   JOURNAL OF CLINICAL ONCOLOGY

Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks

(2012) Jonathan D. Ellis et al.   MOLECULAR CELL

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Children's Oncology Group's 2013 blueprint for research: Bone tumors

(2012) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

(2012) J. Merkin et al.   SCIENCE

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Oncogenic Fusion Protein EWS/FLI1 Down-regulates Gene Expression by Both Transcriptional and Posttranscriptional Mechanisms

(2011) Kelly A. France et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor

(2011) Kensuke Ninomiya et al.   JOURNAL OF CELL BIOLOGY

The Ewing Sarcoma Protein Regulates DNA Damage-Induced Alternative Splicing

(2011) Maria Paola Paronetto et al.   MOLECULAR CELL

Liprin-Mediated Large Signaling Complex Organization Revealed by the Liprin-α/CASK and Liprin-α/Liprin-β Complex Structures

(2011) Zhiyi Wei et al.   MOLECULAR CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

SomaticSF3B1Mutation in Myelodysplasia with Ring Sideroblasts

(2011) E. Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modeling Initiation of Ewing Sarcoma in Human Neural Crest Cells

(2011) Cornelia von Levetzow et al.   PLoS One

Oncogenic Partnerships: EWS-FLI1 Protein Interactions Initiate Key Pathways of Ewing's Sarcoma

(2010) H. V. Erkizan et al.   CLINICAL CANCER RESEARCH

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Impact ofEWS-ETSFusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results From the Cooperative Euro-E.W.I.N.G. 99 Trial

(2010) Marie-Cecile Le Deley et al.   JOURNAL OF CLINICAL ONCOLOGY

Current Treatment Protocols Have Eliminated the Prognostic Advantage of Type 1 Fusions in Ewing Sarcoma: A Report From the Children's Oncology Group

(2010) John A. van Doorninck et al.   JOURNAL OF CLINICAL ONCOLOGY

Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial

(2010) Ruth Ladenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

easyExon – A Java-based GUI tool for processing and visualization of Affymetrix exon array data

(2009) Ting-Yu Chang et al.   BMC BIOINFORMATICS

Polypyrimidine tract binding proteins (PTB) regulate the expression of apoptotic genes and susceptibility to caspase-dependent apoptosis in differentiating cardiomyocytes

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Analysis of Ewing Sarcoma (EWS)-Binding Proteins: Interaction with hnRNP M, U, and RNA-Helicases p68/72 within Protein−RNA Complexes

(2009) Steffen Pahlich et al.   JOURNAL OF PROTEOME RESEARCH

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

CASP3 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck

(2008) K. Chen et al.   CLINICAL CANCER RESEARCH

Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

(2008) G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA