Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health

The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study

(2020) Sherin Bakhashab et al.   Genes

Roles and mechanisms of alternative splicing in cancer — implications for care

(2020) Sophie C. Bonnal et al.   Nature Reviews Clinical Oncology

Specific histone modifications associate with alternative exon selection during mammalian development

(2020) Qiwen Hu et al.   NUCLEIC ACIDS RESEARCH

Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism

(2020) Ying-Chin Lin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation

(2019) Chiara Naro et al.   Cell Reports

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

(2019) Elena A. Matveeva et al.   Epigenetics & Chromatin

SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing

(2019) Suryasree Subramania et al.   NUCLEIC ACIDS RESEARCH

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells

(2019) Cheng Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging roles of histone modifications and HDACs in RNA splicing

(2019) Raneen Rahhal et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing events during adipogenesis from hMSCs

(2019) Xia Yi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A comprehensive study on genome-wide coexpression network of KHDRBS1/Sam68 reveals its cancer and patient-specific association

(2019) B. Sumithra et al.   Scientific Reports

Contribution of adipogenesis to healthy adipose tissue expansion in obesity

(2019) Lavanya Vishvanath et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing

(2019) Jessica S. Elman et al.   Cell Reports

Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis

(2019) Ching-Sheng Hung et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons

(2019) Matthew E. Klein et al.   Cell Reports

Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity

(2019) Zachary J. Ward et al.   NEW ENGLAND JOURNAL OF MEDICINE

The FTO gene polymorphism rs9939609 is associated with obesity and disability in multiple sclerosis patients

(2019) Ahmad Al-Serri et al.   Scientific Reports

Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression

(2019) Peng Xue et al.   Redox Biology

Histone and RNA-binding protein interaction creates crosstalk network for regulation of alternative splicing

(2018) Yong-Eun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis

(2018) Jung-Chun Lin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Characterization of RUNX1T1, an Adipogenesis Regulator in Ovine Preadipocyte Differentiation

(2018) Kaiping Deng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis

(2018) Yves Mugabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

(2018) Niels Grarup et al.   NATURE GENETICS

RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism

(2018) Yi-Lin Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis

(2018) Hui-Yu Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prespliceosome structure provides insights into spliceosome assembly and regulation

(2018) Clemens Plaschka et al.   NATURE

CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer

(2018) Jianbo Tian et al.   NUCLEIC ACIDS RESEARCH

PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation

(2018) Marianna Aprile et al.   Cell Reports

Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals

(2017) Marco Preußner et al.   MOLECULAR CELL

Alternative splicing: A thermometer controlling gene expression

(2017) Linda Koch   NATURE REVIEWS GENETICS

Splicing and transcription touch base: co-transcriptional spliceosome assembly and function

(2017) Lydia Herzel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision

(2017) Yungang Xu et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Alternative Splicing May Not Be the Key to Proteome Complexity

(2017) Michael L. Tress et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

(2017) Justin J. -L. Wong et al.   Nature Communications

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets

(2017) Naomi Li et al.   Oncotarget

RBM4–Nova1–SRSF6 splicing cascade modulates the development of brown adipocytes

(2016) Jung-Chun Lin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Corepressor diversification by alternative mRNA splicing is species specific

(2016) Martin L. Privalsky et al.   BMC EVOLUTIONARY BIOLOGY

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

(2016) Xiaochang Zhang et al.   CELL

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

(2016) Xinping Yang et al.   CELL

Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution

(2016) Anna Ehrlund et al.   DIABETES

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

(2016) Tassa Saldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes

(2016) Jung-Chun Lin et al.   Scientific Reports

Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes

(2016) Curtis A. Nutter et al.   Cell Reports

An alternative splicing program promotes adipose tissue thermogenesis

(2016) Santiago Vernia et al.   eLife

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Cellular origins of cold-induced brown adipocytes in adult mice

(2015) Yun-Hee Lee et al.   FASEB JOURNAL

Inhibition of Sam68 triggers adipose tissue browning

(2015) J. Zhou et al.   JOURNAL OF ENDOCRINOLOGY

Sam68 Regulates S6K1 Alternative Splicing during Adipogenesis

(2015) Jingwen Song et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling

(2015) Chelsea A. Snyder et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation

(2015) Qiong A. Wang et al.   NATURE CELL BIOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Replacing SNAP-25b with SNAP-25a expression results in metabolic disease

(2015) Ismael Valladolid-Acebes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes

(2015) Jung-Chun Lin   RNA Biology

Structural basis of pre-mRNA splicing

(2015) Jing Hang et al.   SCIENCE

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

14-3-3ζ coordinates adipogenesis of visceral fat

(2015) Gareth E. Lim et al.   Nature Communications

SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing

(2015) Ning Wei et al.   Cell Reports

SAM68: Signal Transduction and RNA Metabolism in Human Cancer

(2015) Paola Frisone et al.   Biomed Research International

Emerging role for RNA binding motif protein 4 in the development of brown adipocytes

(2014) Jung-Chun Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

NT-PGC-1α Activation Attenuates High-Fat Diet–Induced Obesity by Enhancing Brown Fat Thermogenesis and Adipose Tissue Oxidative Metabolism

(2014) Hee-Jin Jun et al.   DIABETES

Transformer 2β homolog (Drosophila) (TRA2B) Regulates Protein Kinase C δI (PKCδI) Splice Variant Expression during 3T3L1 Preadipocyte Cell Cycle

(2014) Rekha S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing

(2014) Chen Du et al.   JOURNAL OF LIPID RESEARCH

SRSF10 Regulates Alternative Splicing and Is Required for Adipocyte Differentiation

(2014) H. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping

(2014) Gwendal Dujardin et al.   MOLECULAR CELL

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation

(2014) Xuexia Zhou et al.   NUCLEIC ACIDS RESEARCH

PPARGin Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms

(2014) M. Aprile et al.   PPAR Research

Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells

(2014) Denise Cooper et al.   Genes

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels

(2013) D. A. Baerenwald et al.   DIABETOLOGIA

Protein Kinase C δ (PKCδ) Splice Variants Modulate Apoptosis Pathway in 3T3L1 Cells during Adipogenesis

(2013) Rekha Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Clk/STY (cdc2-Like Kinase 1) and Akt Regulate Alternative Splicing and Adipogenesis in 3T3-L1 Pre-Adipocytes

(2013) Pengfei Li et al.   PLoS One

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

(2012) D. Kaminska et al.   DIABETES

The Sam68 STAR RNA-Binding Protein Regulates mTOR Alternative Splicing during Adipogenesis

(2012) Marc-Étienne Huot et al.   MOLECULAR CELL

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

(2012) Pierre Close et al.   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

(2012) Madapura M. Pradeepa et al.   PLoS Genetics

Stay lean without dieting

(2012) Marc-Étienne Huot et al.   Adipocyte

An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming

(2011) Mathieu Gabut et al.   CELL

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

(2011) Jussi Pihlajamäki et al.   Cell Metabolism

Alternative mRNA Splicing of Corepressors Generates Variants That Play Opposing Roles in Adipocyte Differentiation

(2011) Michael L. Goodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

(2011) K. H. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels

(2010) Qi Sun et al.   HUMAN MOLECULAR GENETICS

Deciphering the splicing code

(2010) Yoseph Barash et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Developmentally spliced PKCβII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport

(2009) E. Kleiman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart

(2009) Ying Feng et al.   DEVELOPMENTAL CELL

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients

(2009) Riccardo Sarzani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Alternative splicing determines the interaction of SMRT isoforms with nuclear receptor–DNA complexes

(2008) Flavie Faist et al.   BIOSCIENCE REPORTS

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator

(2008) Ying Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LMNAmRNA Expression Is Altered in Human Obesity and Type 2 Diabetes

(2008) Merce Miranda et al.   Obesity

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

(2008) R. R. Nofsinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative approach to a heavy weight problem

(2007) A. Goren et al.   GENOME RESEARCH