Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1

(2015) Yoichiro Sugimoto et al.   NATURE

Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5

(2015) Karlie Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc–dependent mechanism

(2014) Aymeric Ravel-Chapuis et al.   MOLECULAR BIOLOGY OF THE CELL

Functional signature for the recognition of specific target mRNAs by human Staufen1 protein

(2014) Susana de Lucas et al.   NUCLEIC ACIDS RESEARCH

RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1

(2014) Roscoe Klinck et al.   PLoS One

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown

(2013) R. A. Elbarbary et al.   GENES & DEVELOPMENT

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Staufen1 senses overall transcript secondary structure to regulate translation

(2013) Emiliano P Ricci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity

(2013) John D. Laver et al.   NUCLEIC ACIDS RESEARCH

Myotonic dystrophy

(2012) Mani S. Mahadevan   CURRENT OPINION IN NEUROLOGY

Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model

(2012) B. Llamusi et al.   Disease Models & Mechanisms

The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

(2012) Aymeric Ravel-Chapuis et al.   JOURNAL OF CELL BIOLOGY

MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1

(2012) Vincent Huin et al.   JOURNAL OF NEUROLOGY

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

(2012) Yang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Muscleblind-Like 1 Knockout Mice Reveal Novel Splicing Defects in the Myotonic Dystrophy Brain

(2012) Koichi Suenaga et al.   PLoS One

Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

(2012) J. Merkin et al.   SCIENCE

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing

(2011) C.M. Dhaenens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

(2011) Chenguang Gong et al.   NATURE

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy

(2011) Charlotte Fugier et al.   NATURE MEDICINE

New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

(2011) François-Xavier Laurent et al.   NUCLEIC ACIDS RESEARCH

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

(2011) Agnieszka Mykowska et al.   NUCLEIC ACIDS RESEARCH

Alu elements: know the SINEs

(2011) Prescott Deininger   GENOME BIOLOGY

Muscleblind-like 1 (Mbnl1) Promotes Insulin Receptor Exon 11 Inclusion via Binding to a Downstream Evolutionarily Conserved Intronic Enhancer

(2010) Supriya Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy

(2010) Hongqing Du et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multimerization of Staufen1 in live cells

(2010) C. Martel et al.   RNA

Mammalian Staufen 1 is recruited to stress granules and impairs their assembly

(2009) M. G. Thomas et al.   JOURNAL OF CELL SCIENCE

Pathogenic RNAs in microsatellite expansion disease

(2009) Jihae Shin et al.   NEUROSCIENCE LETTERS

An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM

(2009) Tibor Pastor et al.   NUCLEIC ACIDS RESEARCH

Modulation of alternative splicing by long-range RNA structures in Drosophila

(2009) Veronica A. Raker et al.   NUCLEIC ACIDS RESEARCH

SRp20 and CUG-BP1 Modulate Insulin Receptor Exon 11 Alternative Splicing

(2008) S. Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Conserved RNA secondary structures promote alternative splicing

(2008) P. J. Shepard et al.   RNA

Intronic Alus Influence Alternative Splicing

(2008) Galit Lev-Maor et al.   PLoS Genetics