The potential of engineered eukaryotic RNA‐binding proteins as molecular tools and therapeutics

Delineation of pentatricopeptide repeat codes for target RNA prediction

(2019) Junjie Yan et al.   NUCLEIC ACIDS RESEARCH

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Advances in CRISPR-Cas systems for RNA targeting, tracking and editing

(2019) Fei Wang et al.   BIOTECHNOLOGY ADVANCES

Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells

(2019) Joseph R. Simon et al.   MOLECULAR CELL

Bioactive cell penetrating peptides and proteins in cancer: a bright future ahead

(2019) Toni Jauset et al.   CURRENT OPINION IN PHARMACOLOGY

Engineering the AAV capsid to evade immune responses

(2019) Christopher Barnes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems

(2018) Mitchell R. O'Connell   JOURNAL OF MOLECULAR BIOLOGY

Expanding RNA binding specificity and affinity of engineered PUF domains

(2018) Yang-Yang Zhao et al.   NUCLEIC ACIDS RESEARCH

An engineered RNA binding protein with improved splicing regulation

(2018) Melissa A Hale et al.   NUCLEIC ACIDS RESEARCH

Development of Toolboxes for Precision Genome/epigenome Editing and Imaging of Epigenetics

(2018) Wataru Nomura   CHEMICAL RECORD

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity

(2017) Lingna Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular delivery of proteins by nanocarriers

(2017) Moumita Ray et al.   Nanomedicine

RNA-binding specificity landscapes of designer pentatricopeptide repeat proteins elucidate principles of PPR–RNA interactions

(2017) Rafael G Miranda et al.   NUCLEIC ACIDS RESEARCH

RNA-binding specificity landscape of the pentatricopeptide repeat protein PPR10

(2017) Rafael G. Miranda et al.   RNA

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Design of a synthetic luminescent probe from a biomolecule binding domain: selective detection of AU-rich mRNA sequences

(2017) Laurent Raibaut et al.   Chemical Science

Inducible Control of mRNA Transport Using Reprogrammable RNA-Binding Proteins

(2017) Zhanar Abil et al.   ACS Synthetic Biology

RNA biology of disease-associated microsatellite repeat expansions

(2017) Kushal J. Rohilla et al.   Acta Neuropathologica Communications

An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription

(2016) David W. Crawford et al.   ACS Chemical Biology

The new (dis)order in RNA regulation

(2016) Aino I. Järvelin et al.   Cell Communication and Signaling

Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants

(2016) Shifeng Cheng et al.   PLANT JOURNAL

Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins

(2016) Cuicui Shen et al.   Nature Communications

G-Quadruplex DNA- and RNA-Specific-Binding Proteins Engineered from the RGG Domain of TLS/FUS

(2015) Kentaro Takahama et al.   ACS Chemical Biology

Myotonic dystrophies: An update on clinical aspects, genetic, pathology, and molecular pathomechanisms

(2015) Giovanni Meola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RNA Toxicity and Missplicing in the Common Eye Disease Fuchs Endothelial Corneal Dystrophy

(2015) Jintang Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific RNA Recognition by Designer Pentatricopeptide Repeat Protein

(2015) Cuicui Shen et al.   Molecular Plant

A giant molecular proton pump: structure and mechanism of respiratory complex I

(2015) Leonid A. Sazanov   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A universal strategy for regulating mRNA translation in prokaryotic and eukaryotic cells

(2015) Jicong Cao et al.   NUCLEIC ACIDS RESEARCH

Predictable Alteration of Sequence Recognition by RNA Editing Factors from Arabidopsis

(2015) Peter Kindgren et al.   PLANT CELL

In vivo analysis of trypanosome mitochondrial RNA function by artificial site-specific RNA endonuclease-mediated knockdown

(2015) Anthony J. Szempruch et al.   RNA

Engineering RNA-binding proteins with diverse activities

(2015) Huanhuan Wei et al.   Wiley Interdisciplinary Reviews-RNA

Bidirectional Regulation of mRNA Translation in Mammalian Cells by Using PUF Domains

(2014) Jicong Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease

(2014) Arunoday Bhan et al.   ChemMedChem

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

A protein-RNA specificity code enables targeted activation of an endogenous human transcript

(2014) Zachary T Campbell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative analysis of motifs contributing to the interaction between PLS-subfamily members and their target RNA sequences in plastid RNA editing

(2014) Kenji Okuda et al.   PLANT JOURNAL

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

An artificial PPR scaffold for programmable RNA recognition

(2014) Sandrine Coquille et al.   Nature Communications

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

(2013) Kentaro Takahama et al.   CHEMISTRY & BIOLOGY

Engineered proteins with Pumilio/fem-3mRNA binding factor scaffold to manipulate RNA metabolism

(2013) Yang Wang et al.   FEBS Journal

Replication and trafficking of a plant virus are coupled at the entrances of plasmodesmata

(2013) Jens Tilsner et al.   JOURNAL OF CELL BIOLOGY

Treatment of Type 1 Myotonic Dystrophy by Engineering Site-specific RNA Endonucleases that Target (CUG) n Repeats

(2013) Wenjing Zhang et al.   MOLECULAR THERAPY

Structural basis for the modular recognition of single-stranded RNA by PPR proteins

(2013) Ping Yin et al.   NATURE

The RNA-binding protein repertoire of embryonic stem cells

(2013) S Chul Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elucidation of the RNA Recognition Code for Pentatricopeptide Repeat Proteins Involved in Organelle RNA Editing in Plants

(2013) Yusuke Yagi et al.   PLoS One

Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein

(2013) D. Melamed et al.   RNA

The many functions of mRNA localization during normal development and disease: from pillar to post

(2013) Neal A.L. Cody et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Fusion protein linkers: Property, design and functionality

(2012) Xiaoying Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2

(2012) J. C. Schwartz et al.   GENES & DEVELOPMENT

Combinatorial Mutagenesis of MBNL1 Zinc Fingers Elucidates Distinct Classes of Regulatory Events

(2012) J. Purcell et al.   MOLECULAR AND CELLULAR BIOLOGY

A Eukaryotic Translation Initiation Factor 4E-Binding Protein Promotes mRNA Decapping and Is Required for PUF Repression

(2012) N. H. Blewett et al.   MOLECULAR AND CELLULAR BIOLOGY

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

KH domains with impaired nucleic acid binding as a tool for functional analysis

(2012) David Hollingworth et al.   NUCLEIC ACIDS RESEARCH

The TGB1 Movement Protein of Potato virus X Reorganizes Actin and Endomembranes into the X-Body, a Viral Replication Factory

(2012) J. Tilsner et al.   PLANT PHYSIOLOGY

ATP-independent diffusion of double-stranded RNA binding proteins

(2012) H. R. Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements

(2012) A. Y. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkers in the structural biology of protein-protein interactions

(2012) Vishnu Priyanka Reddy Chichili et al.   PROTEIN SCIENCE

Engineering RNA endonucleases with customized sequence specificities

(2012) Rajarshi Choudhury et al.   Nature Communications

A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins

(2012) Alice Barkan et al.   PLoS Genetics

Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems

(2012) Yutaka Muto et al.   Wiley Interdisciplinary Reviews-RNA

The birth of the Epitranscriptome: deciphering the function of RNA modifications

(2012) Yogesh Saletore et al.   GENOME BIOLOGY

Alternative splicing regulation by Muscleblind proteins: from development to disease

(2011) Juan M. Fernandez-Costa et al.   BIOLOGICAL REVIEWS

RNA splicing: disease and therapy

(2011) A. G. L. Douglas et al.   Briefings in Functional Genomics

Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains

(2011) Shuyun Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA

(2011) Cuong D. Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Evolution of RNA-Binding Proteins in Animals: Insights from Genome-Wide Analysis in the Sponge Amphimedon queenslandica

(2011) P. Kerner et al.   MOLECULAR BIOLOGY AND EVOLUTION

A universal code for RNA recognition by PUF proteins

(2011) Aleksandra Filipovska et al.   Nature Chemical Biology

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

RNA targets of wild-type and mutant FET family proteins

(2011) Jessica I Hoell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The prospects for designer single-stranded RNA-binding proteins

(2011) Joel P Mackay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted translational regulation using the PUF protein family scaffold

(2011) A. Cooke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2

(2011) S. Sun et al.   RNA

Stacking interactions in PUF-RNA complexes

(2011) Y. Y. Koh et al.   RNA

The DEAD-box RNA Helicase DDX6 is Required for Efficient Encapsidation of a Retroviral Genome

(2011) Shuyuarn F. Yu et al.   PLoS Pathogens

Fabrication of a Structure-Specific RNA Binder for Array Detection of Label-Free MicroRNA

(2010) Jeong Min Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin

(2010) Bernard Krust et al.   BIOCHIMIE

Nucleolin on the Cell Surface as a New Molecular Target for Gastric Cancer Treatment

(2010) Tatsuro Watanabe et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove

(2010) Richard Stefl et al.   CELL

Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy

(2010) Hongqing Du et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins

(2010) Andrew G. Cridge et al.   NUCLEIC ACIDS RESEARCH

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

Sequential Recruitment of the Endoplasmic Reticulum and Chloroplasts for Plant Potyvirus Replication

(2009) T. Wei et al.   JOURNAL OF VIROLOGY

Engineering splicing factors with designed specificities

(2009) Yang Wang et al.   NATURE METHODS

The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences

(2009) F. E. Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1

(2008) Marianna Teplova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Live-cell imaging of viral RNA genomes using a Pumilio-based reporter

(2008) Jens Tilsner et al.   PLANT JOURNAL

Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin

(2008) Damien Destouches et al.   PLoS One

Genome-Wide Survey and Expression Profiling of CCCH-Zinc Finger Family Reveals a Functional Module in Macrophage Activation

(2008) Jian Liang et al.   PLoS One

Structures of Human Pumilio with Noncognate RNAs Reveal Molecular Mechanisms for Binding Promiscuity

(2008) Yogesh K. Gupta et al.   STRUCTURE

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY