Short-chain fatty acid – A critical interfering factor for allergic diseases

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

(2023) Albert Stec et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut-derived short-chain fatty acids bridge cardiac and systemic metabolism and immunity in heart failure

(2023) Anzhu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

(2023) Yijie Yang et al.   Cell Death & Disease

Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

(2023) William Fusco et al.   Nutrients

Gut microbiota changes associated with Clostridioides difficile infection and its various treatment strategies

(2023) Anne J. Gonzales-Luna et al.   Gut Microbes

The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials

(2023) Hongliang Duan et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin in food allergy: Mechanism and potential therapy

(2023) Hao Wang et al.   JOURNAL OF PINEAL RESEARCH

Human milk oligosaccharides: potential therapeutic aids for allergic diseases

(2023) Isabel Tarrant et al.   TRENDS IN IMMUNOLOGY

Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease

(2023) Courtney Hoskinson et al.   Nature Communications

Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier

(2023) Xiuchuan Hu et al.   Nature Communications

Gut microbiome and health: mechanistic insights

(2022) Willem M de Vos et al.   GUT

Lower caprylate and acetate levels in the breast milk is associated with atopic dermatitis in infancy

(2022) Li‐Chieh Wang et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Gut microbiota and allergic diseases in children

(2022) Shohei Akagawa et al.   ALLERGOLOGY INTERNATIONAL

Disordered development of gut microbiome interferes with the establishment of the gut ecosystem during early childhood with atopic dermatitis

(2022) Min-Jung Lee et al.   Gut Microbes

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

(2022) Aurélien Trompette et al.   Mucosal Immunology

Breastfeeding and Allergy Effect Modified by Genetic, Environmental, Dietary, and Immunological Factors

(2022) Hanna Danielewicz   Nutrients

Effect of gut microbial composition and diversity on major inhaled allergen sensitization and onset of allergic rhinitis

(2022) Taimu Yamaguchi et al.   ALLERGOLOGY INTERNATIONAL

Current use of probiotics and prebiotics in allergy

(2022) Alessandro Fiocchi et al.   Journal of Allergy and Clinical Immunology-In Practice

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

(2022) Morgane Modoux et al.   Gut Microbes

Allergic disease trajectories up to adolescence: Characteristics, early‐life, and genetic determinants

(2022) Anna Kilanowski et al.   ALLERGY

Gut Microbiota and Fecal Microbiota Transplantation in Patients with Food Allergies: A Systematic Review

(2022) Caroline Jensen et al.   Microorganisms

Oral Tolerance Induction—Opportunities and Mechanisms

(2022) Ru-Xin Foong et al.   Foods

Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

(2022) Min Zhao et al.   Nature Communications

Transcription factor ZNF22 regulates blood-tumor barrier permeability by interacting with HDAC3 protein

(2022) Baicheng Zhu et al.   Frontiers in Molecular Neuroscience

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

(2021) Wenjing Yang et al.   Cellular & Molecular Immunology

Both living and dead Faecalibacterium prausnitzii alleviate HDM ‐induced allergic asthma through the modulation of gut microbiota and short‐chain fatty acid ( SCFAs ) production

(2021) Wenbing Hu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

EAACI guideline: preventing the development of food allergy in infants and young children (2020 update)

(2021) Susanne Halken et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action

(2021) Miguel Hernandez-Quiles et al.   Frontiers in Endocrinology

Exploring the Effect of Probiotics, Prebiotics, and Postbiotics in Strengthening Immune Activity in the Elderly

(2021) Hiroyasu Akatsu   Vaccines

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

(2021) Chang H. Kim   Cellular & Molecular Immunology

Induction of the apoptosis, degranulation and IL‐13 production of human basophils by butyrate and propionate via suppression of histone deacetylation

(2021) Yanbiao Shi et al.   IMMUNOLOGY

Molecular Mechanisms of Atopic Dermatitis Pathogenesis

(2021) Jowita Sroka-Tomaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis

(2021) Dong Hoon Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin D and Microbiota: Is There a Link with Allergies?

(2021) Giuseppe Murdaca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multi-dimensional study of the oral microbiome, metabolite, and immunologic environment in peanut allergy

(2021) Hsi-en Ho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function

(2021) Mirelle T.A. Kleuskens et al.   ALLERGY

Gut-microbiota-targeted diets modulate human immune status

(2021) Hannah C. Wastyk et al.   CELL

The Dietary Fiber Pectin: Health Benefits and Potential for the Treatment of Allergies by Modulation of Gut Microbiota

(2021) Frank Blanco-Pérez et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Tolerance development in cow’s milk–allergic infants receiving amino acid–based formula: A randomized controlled trial

(2021) Pantipa Chatchatee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The maternal gut microbiome during pregnancy and offspring allergy and asthma

(2021) Yuan Gao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

(2021) Naschla Gasaly et al.   Frontiers in Immunology

Associations Between Gut Microbiota and Asthma Endotypes: A Cross-Sectional Study in South China Based on Patients with Newly Diagnosed Asthma

(2021) Xiao-Ling Zou et al.   Journal of Asthma and Allergy

Low Concentration of Fecal Valeric Acid at 1 Year of Age Is Linked with Eczema and Food Allergy at 13 Years of Age: Findings from a Swedish Birth Cohort

(2021) Monica Gio-Batta et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

2021 year in review: Spotlight on eosinophils

(2021) Julia L.M. Dunn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Food allergy across the globe

(2021) Vanitha Sampath et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dietary Fibers: Effects, Underlying Mechanisms and Possible Role in Allergic Asthma Management

(2021) Roos E. M. Verstegen et al.   Nutrients

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

(2021) Shuting Wen et al.   Frontiers in Immunology

Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma

(2021) Xinyue Hu et al.   Frontiers in Immunology

Short-Chain Fatty Acids Calibrate RARα Activity Regulating Food Sensitization

(2021) Xiefang Yuan et al.   Frontiers in Immunology

Clinical efficacy of fecal microbial transplantation treatment in adults with moderate‐to‐severe atopic dermatitis

(2021) Jacob Mashiah et al.   Immunity Inflammation and Disease

Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI‐mediated signaling

(2020) Jelle Folkerts et al.   ALLERGY

Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

(2020) Gianluca Galazzo et al.   GASTROENTEROLOGY

New Perspectives in Food Allergy

(2020) Massimo De Martinis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysbiosis of Fecal Microbiota in Allergic Rhinitis Patients

(2020) Xiang Liu et al.   American Journal of Rhinology & Allergy

SCFA: mechanisms and functional importance in the gut

(2020) Camille Martin-Gallausiaux et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review

(2020) Małgorzata Moszak et al.   Nutrients

Atopic dermatitis

(2020) Sinéad M Langan et al.   LANCET

Dietary fiber metabolites regulate innate lymphoid cell responses

(2020) Ali Sepahi et al.   Mucosal Immunology

Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy

(2020) Maik Luu et al.   Frontiers in Immunology

Food Allergy from Infancy Through Adulthood

(2020) Scott H. Sicherer et al.   Journal of Allergy and Clinical Immunology-In Practice

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity

(2020) Fangcong Dong et al.   Gut Microbes

Butyrate as bioactive human milk protective component against food allergy

(2020) Lorella Paparo et al.   ALLERGY

Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy

(2020) Nathalie Esber et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

Effects of Maternal Fiber Intake on Intestinal Morphology, Bacterial Profile and Proteome of Newborns Using Pig as Model

(2020) Ying He et al.   Nutrients

Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma

(2020) Arwa Abu Khweek et al.   Frontiers in Immunology

Allergic rhinitis

(2020) Jean Bousquet et al.   Nature Reviews Disease Primers

The Role of Prebiotics and Probiotics in Prevention of Allergic Diseases in Infants

(2020) Simona Sestito et al.   Frontiers in Pediatrics

Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow’s Milk Allergic Mice

(2019) Marlotte M. Vonk et al.   MEDIATORS OF INFLAMMATION

Healthy infants harbor intestinal bacteria that protect against food allergy

(2019) Taylor Feehley et al.   NATURE MEDICINE

Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

(2019) Ludovica Marinelli et al.   Scientific Reports

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

(2019) Rikke Meineche Schmidt et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

(2019) Ioana Agache et al.   JOURNAL OF CLINICAL INVESTIGATION

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

(2019) Anna Theiler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The pros, cons, and many unknowns of probiotics

(2019) Jotham Suez et al.   NATURE MEDICINE

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance

(2019) Wei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

FoxP3 in T reg cell biology: a molecular and structural perspective

(2019) G. Deng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells

(2019) Christopher J.M. Piper et al.   Cell Reports

Altered microbial community structure and metabolism in cow’s milk allergic mice treated with oral immunotherapy and fructo-oligosaccharides

(2019) M.M. Vonk et al.   Beneficial Microbes

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Mechanisms of Oral Tolerance

(2018) Leticia Tordesillas et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Oral Tolerance Development and Maintenance

(2018) Erik Wambre et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Regulation of type 2 innate lymphoid cell–dependent airway hyperreactivity by butyrate

(2018) Christina Li-Ping Thio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast cells signal their importance in health and disease

(2018) Ana Olivera et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PPAR-γ in innate and adaptive lung immunity

(2018) Samuel Philip Nobs et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Aryl hydrocarbon receptor and intestinal immunity

(2018) Bruno Lamas et al.   Mucosal Immunology

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Different Upper Airway Microbiome and Their Functional Genes Associated with Asthma in Young Adults and Elderly Individuals

(2018) Jin-Jae Lee et al.   ALLERGY

Airway Epithelial Cell Peroxisome Proliferator–Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease

(2018) Sowmya P. Lakshmi et al.   JOURNAL OF IMMUNOLOGY

Early Dietary Intervention with a Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Allergic Manifestations and Infections during the First Two Years of Life

(2018) Sertac Arslanoglu et al.   JOURNAL OF NUTRITION

Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy

(2018) Roberto Berni Canani et al.   Scientific Reports

High levels of butyrate and propionate in early life are associated with protection against atopy

(2018) Caroline Roduit et al.   ALLERGY

Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years

(2018) Kristin Wickens et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Taking a prebiotic approach to early immunomodulation for allergy prevention

(2017) Rachelle Pretorius et al.   Expert Review of Clinical Immunology

The nutrition-gut microbiome-physiology axis and allergic diseases

(2017) Craig McKenzie et al.   IMMUNOLOGICAL REVIEWS

Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial

(2017) Roberto Berni Canani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

(2017) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation

(2017) Zuzana Tylichová et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria

(2017) Jean Guy LeBlanc et al.   Microbial Cell Factories

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion

(2017) Mariana X. Byndloss et al.   SCIENCE

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

(2017) Annie Luo et al.   Frontiers in Immunology

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow’s Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells

(2017) Marlotte M. Vonk et al.   Frontiers in Immunology

Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial

(2016) R. J. Boyle et al.   ALLERGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Faecalibacterium prausnitzii subspecies–level dysbiosis in the human gut microbiome underlying atopic dermatitis

(2016) Han Song et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

A dendritic cell subset designed for oral tolerance

(2016) Reinhard Hinterleitner et al.   NATURE IMMUNOLOGY

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

(2016) Takanori Hidaka et al.   NATURE IMMUNOLOGY

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

(2016) Elizabeth E. Hull et al.   Biomed Research International

Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity

(2016) Song Hui Chng et al.   Scientific Reports

Infant gut microbiota and food sensitization: associations in the first year of life

(2015) M. B. Azad et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

A protective effect of Lactobacillus rhamnosusHN001 against eczema in the first 2 years of life persists to age 4 years

(2012) K. Wickens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants

(2010) Christoph Grüber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Early markers of allergic disease in a primary prevention study using probiotics: 2.5-year follow-up phase

(2008) S. L. Prescott et al.   ALLERGY

Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases

(2008) M. Tachibana et al.   ALLERGY

A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial

(2008) Kristin Wickens et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Randomized, Double-Blind, Placebo-Controlled Trial of Probiotics for Primary Prevention: No Clinical Effects of Lactobacillus GG Supplementation

(2008) M. V. Kopp et al.   PEDIATRICS