Exploring the Molecular Mechanisms Underlying the Protective Effects of Microbial SCFAs on Intestinal Tolerance and Food Allergy

Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy

(2020) Ramona A. Hoh et al.   Science Immunology

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

(2019) Nielson T. Baxter et al.   mBio

Short‐chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells

(2019) Maik Luu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells

(2019) Alexander Visekruna et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production

(2019) Satoko Hara et al.   Frontiers in Immunology

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases

(2018) Jelle Folkerts et al.   Frontiers in Immunology

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

(2018) Yanhai Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy

(2018) Roberto Berni Canani et al.   Scientific Reports

High levels of butyrate and propionate in early life are associated with protection against atopy

(2018) Caroline Roduit et al.   ALLERGY

An Insight Into the Intestinal Web of Mucosal Immunity, Microbiota, and Diet in Inflammation

(2018) Yu Anne Yap et al.   Frontiers in Immunology

Immunology of Food Allergy

(2017) Leticia Tordesillas et al.   IMMUNITY

Sodium butyrate enhances intestinal integrity, inhibits mast cell activation, inflammatory mediator production and JNK signaling pathway in weaned pigs

(2017) Chun Chun Wang et al.   Innate Immunity

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells

(2017) Gera Goverse et al.   JOURNAL OF IMMUNOLOGY

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone propionylation is a mark of active chromatin

(2017) Adam F Kebede et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling

(2017) Maria M. M. Kaisar et al.   Frontiers in Immunology

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC

(2016) Ronald Schilderink et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2016) Aiden Haghikia et al.   IMMUNITY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

(2016) Sathish Sivaprakasam et al.   PHARMACOLOGY & THERAPEUTICS

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

Regulation of IgE-Mediated Food Allergy by IL-9 Producing Mucosal Mast Cells and Type 2 Innate Lymphoid Cells

(2016) Jee-Boong Lee   Immune Network

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids

(2013) Xiaojiao Zheng et al.   Metabolomics

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Therapeutic Modulation of Microbiota-Host Metabolic Interactions

(2012) E. Holmes et al.   Science Translational Medicine

Microbiota, Disease, and Back to Health: A Metastable Journey

(2012) R. Blumberg et al.   Science Translational Medicine

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE