Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

GPR43 – A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases

(2015) Craig I. McKenzie et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

(2014) Chang H. Kim et al.   Immune Network

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host

(2013) Vadivel Ganapathy et al.   CURRENT OPINION IN PHARMACOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage

(2012) Donna Kirkland et al.   IMMUNITY

Th17 Cells Upregulate Polymeric Ig Receptor and Intestinal IgA and Contribute to Intestinal Homeostasis

(2012) Anthony T. Cao et al.   JOURNAL OF IMMUNOLOGY

Prominent Role for Plasmacytoid Dendritic Cells in Mucosal T Cell-Independent IgA Induction

(2011) Hiroyuki Tezuka et al.   IMMUNITY

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

(2011) Laurence Macia et al.   IMMUNOLOGICAL REVIEWS

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF- 1 and Retinoic Acid Signaling

(2010) K. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Generation of Mucosal Dendritic Cells from Bone Marrow Reveals a Critical Role of Retinoic Acid

(2010) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3

(2009) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota

(2009) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

The Biology of Intestinal Immunoglobulin A Responses

(2008) Andrea Cerutti et al.   IMMUNITY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE