2021 year in review: Spotlight on eosinophils

miR103a-3p in extracellular vesicles from FcεRI-aggregated human mast cells enhances IL-5 production by group 2 innate lymphoid cells

(2021) Shota Toyoshima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A tribute to eosinophils from a comparative and evolutionary perspective

(2021) Nicole I. Stacy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilia in Asthma Patients Is Protective Against Severe COVID-19 Illness

(2021) Denisa Ferastraoaru et al.   Journal of Allergy and Clinical Immunology-In Practice

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

(2021) Elizabeth A. Jacobsen et al.   Annual Review of Immunology

A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis

(2021) Lance Y. Hsieh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Benralizumab for Adolescent Patients with Severe, Eosinophilic Asthma: Safety and Efficacy after Three Years of Treatment

(2021) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma

(2021) Natasha A. Winter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

(2021) Simon Gebremeskel et al.   Frontiers in Immunology

Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

(2021) Yael Renert-Yuval et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

What is the contribution of IgE to nasal polyposis?

(2021) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes

(2021) Julia L. M. Dunn et al.   Mucosal Immunology

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease

(2021) Kathleen M. Buchheit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A genome-wide association meta-analysis identifies new Eosinophilic esophagitis loci

(2021) Xiao Chang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenetic Analysis of the Chromatin Landscape Identifies a Repertoire of Murine Eosinophil-Specific PU.1-Bound Enhancers

(2021) Jennifer M. Felton et al.   JOURNAL OF IMMUNOLOGY

Aiolos regulates eosinophil migration into tissues

(2021) Jennifer M. Felton et al.   Mucosal Immunology

Unsedated transnasal esophagoscopy with virtual reality distraction enables earlier monitoring of dietary therapy in eosinophilic esophagitis

(2021) Joel A. Friedlander et al.   Journal of Allergy and Clinical Immunology-In Practice

Patients with eosinophilic gastrointestinal disorders have lower in-hospital mortality rates related to COVID-19

(2021) Fares Qeadan et al.   Journal of Allergy and Clinical Immunology-In Practice

Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis

(2021) Duncan M. Morgan et al.   Science Immunology

Charcot–Leyden crystals and other protein crystals driving type 2 immunity and allergy

(2021) Helena Aegerter et al.   CURRENT OPINION IN IMMUNOLOGY

The genetic etiology of eosinophilic esophagitis

(2020) Leah C. Kottyan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Serum IL-6: A biomarker in childhood asthma?

(2020) Daniel J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis

(2020) Asawari Korde et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biologics for chronic rhinosinusitis with nasal polyps

(2020) Claus Bachert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis

(2020) Takeshi Tsuda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin

(2020) Tetsuji Takabayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Understanding the Asthmatic Response to an Experimental Rhinovirus Infection: Exploring the Effects of Blocking IgE

(2020) Peter W. Heymann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

(2020) Milica M. Grozdanovic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

αIIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis

(2020) Mats W. Johansson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe eosinophilic asthma with nasal polyposis: A phenotype for improved sino-nasal and asthma outcomes with mepolizumab therapy

(2020) Peter Howarth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Diagnosis and treatment of eosinophilic esophagitis

(2020) Nirmala P. Gonsalves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Baseline sputum eosinophil+neutrophil subgroups’ clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) Cohort

(2020) A.T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Disconnect between effects of mepolizumab on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps

(2020) Rory Chan et al.   Journal of Allergy and Clinical Immunology-In Practice

Eosinophil‐derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma

(2020) Peter Howarth et al.   ALLERGY

Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis

(2020) Evan S. Dellon et al.   Clinical Gastroenterology and Hepatology

Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice

(2020) Cynthia Kanagaratham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

(2020) Rosita Rigoni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 Inflammation in Chronic Rhinosinusitis without Nasal Polyps: Another Relevant Endotype

(2020) Tim Delemarre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 Inflammation Modulates ACE2 and TMPRSS2 in Airway Epithelial Cells

(2020) Hiroki Kimura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of eosinophils in chronic spontaneous urticaria

(2020) Sabine Altrichter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China

(2020) Ruchong Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophil responses during COVID-19 infections and coronavirus vaccination

(2020) Andrew W. Lindsley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An anti-IL-13 antibody reverses epithelial-mesenchymal transition biomarkers in eosinophilic esophagitis: phase 2 trial results

(2020) Peter H. Gann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multi-site cohort

(2020) Julia L.M. Dunn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Active control of mucosal tolerance and inflammation by human IgA and IgG antibodies

(2020) Willianne Hoepel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis

(2020) Nurit P. Azouz et al.   Science Translational Medicine

Eosinophil paradox with mepolizumab in chronic rhinosinusitis with nasal polyposis

(2020) Brian Lipworth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ISOLATION, IDENTIFICATION AND CHARACTERIZATION OF THE HUMAN AIRWAY LIGAND FOR THE EOSINOPHIL AND MAST CELL IMMUNOINHIBITORY RECEPTOR SIGLEC-8

(2020) Anabel Gonzalez-Gil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH cell diversity and response to dupilumab in patients with atopic dermatitis

(2020) Coline Trichot et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic esophagitis with extremely high esophageal eosinophil counts

(2020) Kelly M. O’Shea et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

(2020) Daphne S. Bakker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proteomic analysis of nasal mucus samples of healthy and chronic rhinosinusitis patients

(2020) Stephen Shih-Teng Kao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype

(2020) Matthew Camiolo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials

(2020) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of whole blood gene expressions correlated with responsiveness to benralizumab

(2020) Masayuki Nakajima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma Among Hospitalized Patients with COVID-19 and Related Outcomes

(2020) Stephanie Lovinsky-Desir et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies

(2020) Helen Kühn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single Cell Transcriptomic Analysis Reveals Key Immune Cell Phenotypes in the lung of Asthma Exacerbation

(2020) Hui Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Broad Transcriptional Response of the Human Esophageal Epithelium to Proton Pump Inhibitors

(2020) M. Rochman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Replication and Meta-Analyses Nominate Numerous Eosinophilic Esophagitis Risk Genes

(2020) Leah C. Kottyan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Very Early Onset Eosinophilic Esophagitis is Common, Responds to Standard Therapy, and Demonstrates Enrichment for CAPN14 Genetic Variants

(2020) John L. Lyles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of mepolizumab in hypereosinophilic syndrome: A phase III, randomized, placebo-controlled trial

(2020) Florence Roufosse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps

(2020) Tim Delemarre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Benralizumab for Chronic Spontaneous Urticaria

(2020) Jonathan A. Bernstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

(2020) Evan S. Dellon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms and biomarkers of inflammatory endotypes in chronic rhinosinusitis without nasal polyps

(2020) Aiko I. Klingler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic pulmonary vasculitis as a manifestation of the hyperinflammatory phase of COVID-19

(2020) Eva Luecke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

(2020) Hai Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 Immunity and Age Modify Gene Expression of COVID19 Receptors in Eosinophilic Gastrointestinal Disorders

(2020) Austin W.T. Chiang et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium

(2019) Robert D. Pesek et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis

(2019) Ting Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-37-Mex3B-TLR3 axis in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

(2019) Jin-Xin Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

(2019) Xingnan Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment

(2019) Pavel Kolkhir et al.   Journal of Allergy and Clinical Immunology-In Practice

Emerging therapies for eosinophilic esophagitis

(2019) Thomas Greuter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Advancing Patient Care Through the Consortium of Eosinophilic Gastrointestinal Disease Researchers

(2019) Seema Aceves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic gastrointestinal disease below the belt

(2019) Robert D. Pesek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Relationship of skin barrier breakdown and eosinophilic esophagitis

(2019) Dagmar Simon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe asthma during childhood and adolescence: A longitudinal study

(2019) Kristie R. Ross et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes

(2019) Bruce D. Levy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of anoctamin 1 (ANO1) as a key driver of esophageal epithelial proliferation in eosinophilic esophagitis

(2019) Simone Vanoni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular, Endoscopic, Histologic and Circulating Biomarker-Based Diagnosis of Eosinophilic Gastritis: Multi-Site Study

(2019) Tetsuo Shoda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis

(2019) Ikuo Hirano et al.   GASTROENTEROLOGY

Severe asthma in the US population and eligibility for mAb therapy

(2019) Ayobami Akenroye et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expert-level diagnosis of nasal polyps using deep learning on whole-slide imaging

(2019) Qingwu Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

(2018) Mats W. Johansson et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses

(2018) Nurit P. Azouz et al.   Science Translational Medicine

Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference

(2018) Evan S. Dellon et al.   GASTROENTEROLOGY

RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis

(2018) Ikuo Hirano et al.   GASTROENTEROLOGY

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

(2018) Fanny Legrand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

(2017) Gen Kano et al.   IMMUNOBIOLOGY

Eosinophils in mucosal immune responses

(2015) J Travers et al.   Mucosal Immunology

Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis

(2014) Eileen S. Alexander et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting eosinophils in allergy, inflammation and beyond

(2013) Patricia C. Fulkerson et al.   NATURE REVIEWS DRUG DISCOVERY

Long-term outcomes in pediatric-onset esophageal eosinophilia

(2011) Charles W. DeBrosse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999

(2010) Charles W. DeBrosse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared With Sporadic Cases

(2008) Margaret H. Collins et al.   Clinical Gastroenterology and Hepatology