Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

(2022) Miguel A. Ortega et al.   Metabolites

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure

(2022) Muhammad Imran et al.   CELL BIOLOGY AND TOXICOLOGY

Host/microbiota interactions-derived tryptophan metabolites modulate oxidative stress and inflammation via aryl hydrocarbon receptor signaling

(2022) Yue-Qi Tan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice

(2022) Aneta Grycová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

(2022) Aimée Parker et al.   Microbiome

Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma

(2021) Michal Fiedorowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-93/STAT3 signalling pathway mediates retinal microglial activation and protects retinal ganglion cells in an acute ocular hypertension model

(2021) Yayi Wang et al.   Cell Death & Disease

Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma

(2021) Sujith Kumar Pulukool et al.   Scientific Reports

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

(2021) Gülgün Tezel   PROGRESS IN RETINAL AND EYE RESEARCH

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice

(2021) Meng Ye et al.   Cell Death & Disease

Association of systemic inflammation indices with visual field loss progression in patients with primary angle-closure glaucoma: potential biomarkers for 3P medical approaches

(2021) Shengjie Li et al.   EPMA Journal

Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation

(2020) Giada Mondanelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy

(2020) Thi Hong Khanh Vu et al.   AMERICAN JOURNAL OF PATHOLOGY

Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease

(2020) Patrick L. Heilman et al.   MOVEMENT DISORDERS

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

(2020) Xiangjun Yang et al.   Journal of Neuroinflammation

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Polyamines and Kynurenines at the Intersection of Immune Modulation

(2020) Elisa Proietti et al.   TRENDS IN IMMUNOLOGY

Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

(2020) Pia Grotegut et al.   Journal of Neuroinflammation

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Glaucoma: Current treatment and impact of advanced drug delivery systems

(2019) Khushwant S. Yadav et al.   LIFE SCIENCES

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

(2019) Peixing Wan et al.   CELL DEATH AND DIFFERENTIATION

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation

(2019) Kumar Abhiram Jha et al.   Stem Cell Research & Therapy

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Recent advances in drug and nutrient transport across the blood-retinal barrier

(2018) Yoshiyuki Kubo et al.   Expert Opinion on Drug Metabolism & Toxicology

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Oral Memantine for the Treatment of Glaucoma

(2018) Robert N. Weinreb et al.   OPHTHALMOLOGY

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

(2018) Abdelrahman Y. Fouda et al.   Cell Death & Disease

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

(2018) Huihui Chen et al.   Nature Communications

Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course

(2018) Bardia Nourbakhsh et al.   Annals of Clinical and Translational Neurology

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

(2018) Rahul Shinde et al.   TRENDS IN IMMUNOLOGY

Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases

(2017) Michael D. Lovelace et al.   NEUROPHARMACOLOGY

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

(2017) Sheldon Rowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary angle closure glaucoma: What we know and what we don’t know

(2017) Xinghuai Sun et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

(2016) Shahin Aeinehband et al.   BRAIN BEHAVIOR AND IMMUNITY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Glaucoma

(2011) Harry A Quigley   LANCET

NF-κB and innate immunity in ischemic stroke

(2010) Olivier A. Harari et al.   Annals of the New York Academy of Sciences

Repeated Intraocular Pressure Measurement in Awake Lewis Rats Does Not Bias Retinal Ganglion Cell Survival

(2010) C. S. Cuny et al.   CURRENT EYE RESEARCH