Gut-derived short-chain fatty acids bridge cardiac and systemic metabolism and immunity in heart failure

Inflammation in obesity, diabetes, and related disorders

(2022) Theresa V. Rohm et al.   IMMUNITY

Weight Loss and Short-Chain Fatty Acids Reduce Systemic Inflammation in Monocytes and Adipose Tissue Macrophages from Obese Subjects

(2022) Shaun Eslick et al.   Nutrients

HMGB1‐Promoted Neutrophil Extracellular Traps Contribute to Cardiac Diastolic Dysfunction in Mice

(2022) Xin‐Lin Zhang et al.   Journal of the American Heart Association

Mitochondrial protein hyperacetylation underpins heart failure with preserved ejection fraction in mice

(2022) Xin Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms

(2022) Jibraan A. Fawad et al.   GASTROENTEROLOGY

The Future of Synbiotics: Rational Formulation and Design

(2022) David F. Gomez Quintero et al.   Frontiers in Microbiology

Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake

(2022) Zachary C. Holmes et al.   Microbiome

Short-Chain Fatty Acids in the Metabolism of Heart Failure – Rethinking the Fat Stigma

(2022) Constantin L. Palm et al.   Frontiers in Cardiovascular Medicine

Short Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart

(2021) Andrew N. Carley et al.   CIRCULATION

SGLT2 inhibitors break the vicious circle between heart failure and insulin resistance: targeting energy metabolism

(2021) Xiaodan Wang et al.   HEART FAILURE REVIEWS

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure

(2021) Matthew A. Walker et al.   JCI Insight

HDAC Inhibition in the Heart

(2021) Thomas G. Gillette   CIRCULATION

Obesity Cardiomyopathy: Evidence, Mechanisms and Therapeutic Implications

(2021) Jun Ren et al.   PHYSIOLOGICAL REVIEWS

Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

(2021) Chaoran Li et al.   Cell Metabolism

The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension

(2021) Vijaya Karoor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiome of Heart Failure With Preserved Ejection Fraction

(2021) Anna L. Beale et al.   Journal of the American Heart Association

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism

(2021) Arash Haghikia et al.   EUROPEAN HEART JOURNAL

Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers

(2020) Jeffrey I. Mechanick et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

(2020) Markus Wallner et al.   Science Translational Medicine

Low fibre intake is associated with gut microbiota alterations in chronic heart failure

(2020) Cristiane C.K. Mayerhofer et al.   ESC Heart Failure

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

(2020) David M. Kaye et al.   CIRCULATION

Obesity, Hypertension, and Cardiac Dysfunction

(2020) Alan J. Mouton et al.   CIRCULATION RESEARCH

T-cell regulation of fibroblast and cardiac fibrosis

(2020) Amy D. Bradshaw et al.   MATRIX BIOLOGY

Improving prevention strategies for cardiometabolic disease

(2020) Naveed Sattar et al.   NATURE MEDICINE

Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure

(2020) Michael Thomas Davidson et al.   CIRCULATION RESEARCH

NAFLD and cardiovascular diseases: a clinical review

(2020) Philipp Kasper et al.   Clinical Research in Cardiology

Epidemiology of heart failure

(2020) Amy Groenewegen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

Gut dysbiosis induced by cardiac pressure overload enhances adverse cardiac remodeling in a T cell-dependent manner

(2020) Francisco J Carrillo-Salinas et al.   Gut Microbes

Cross-Priming Dendritic Cells Exacerbate Immunopathology after Ischemic Tissue Damage in the Heart

(2020) Elvira Forte et al.   CIRCULATION

Non-alcoholic fatty liver disease and risk of incident chronic kidney disease: an updated meta-analysis

(2020) Alessandro Mantovani et al.   GUT

CaMKII exacerbates heart failure progression by activating class I HDACs

(2020) Manling Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of Gut Microbiota Alters Immune System Composition and Cripples Post-Infarction Cardiac Repair

(2019) Tony WH Tang et al.   CIRCULATION

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

The Interleukin-1 Axis and Risk of Death in Patients With Acutely Decompensated Heart Failure

(2019) Domingo A. Pascual-Figal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

B Cell Responses: Cell Interaction Dynamics and Decisions

(2019) Jason G. Cyster et al.   CELL

The clinical significance of interleukin‐6 in heart failure: results from the BIOSTAT‐CHF study

(2019) George Markousis‐Mavrogenis et al.   EUROPEAN JOURNAL OF HEART FAILURE

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

(2019) Edward S Chambers et al.   GUT

The economic burden of heart failure in Denmark from 1998 to 2016

(2019) Johan S. Bundgaard et al.   EUROPEAN JOURNAL OF HEART FAILURE

Propionate suppresses hepatic gluconeogenesis via GPR43/AMPK signaling pathway

(2019) Hiroki Yoshida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Developments in understanding and applying prebiotics in research and practice—an ISAPP conference paper

(2019) K.P. Scott et al.   JOURNAL OF APPLIED MICROBIOLOGY

Increased circulating IgG levels, myocardial immune cells and IgG deposits support a role for an immune response in pre‐ and end‐stage heart failure

(2019) Patricia Hoogen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Free Fatty Acid Receptors in Health and Disease

(2019) Ikuo Kimura et al.   PHYSIOLOGICAL REVIEWS

SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity

(2019) Ning Wang et al.   Science Advances

Metabolic reprogramming orchestrates CD4+ T-cell immunological status and restores cardiac dysfunction in autoimmune induced-dilated cardiomyopathy mice

(2019) Jian Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

(2019) Mattea Müller et al.   Scientific Reports

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Assessing the evidence–practice gap for heart failure in China: the Heart Failure Registry of Patient Outcomes (HERO) study design and baseline characteristics

(2019) Li Li et al.   EUROPEAN JOURNAL OF HEART FAILURE

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms

(2019) Rebecca Sadler et al.   JOURNAL OF NEUROSCIENCE

Mapping macrophage polarization over the myocardial infarction time continuum

(2018) Alan J. Mouton et al.   BASIC RESEARCH IN CARDIOLOGY

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice

(2018) Yogi Umbarawan et al.   CARDIOVASCULAR RESEARCH

Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic ResonanceNovelty and Significance

(2018) Andrew J.M. Lewis et al.   CIRCULATION RESEARCH

Cardiac macrophages promote diastolic dysfunction

(2018) Maarten Hulsmans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut Microbiota Signature in Heart Failure Defined From Profiling of 2 Independent Cohorts

(2018) Martin Kummen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals

(2018) Nathalie Conrad et al.   LANCET

Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

(2018) Natasha Fillmore et al.   MOLECULAR MEDICINE

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

The human heart contains distinct macrophage subsets with divergent origins and functions

(2018) Geetika Bajpai et al.   NATURE MEDICINE

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

(2018) Xiao Cui et al.   Scientific Reports

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

(2018) KEC Bouter et al.   Clinical and Translational Gastroenterology

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

(2018) Nazir Savji et al.   JACC-Heart Failure

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

(2018) Agnieszka D. Truax et al.   Cell Host & Microbe

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction

(2018) Jasper Tromp et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling

(2018) Gabor Voros et al.   Circulation-Heart Failure

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Progress in the biology and analysis of short chain fatty acids

(2017) Roel J. Vonk et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice

(2017) Charlotte Pelgrim et al.   Nutrients

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

(2017) Toru Suzuki et al.   Cell Reports

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

(2017) Takehiro Kamo et al.   PLoS One

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

Mortality Among Patients Hospitalized With Heart Failure and Diabetes MellitusCLINICAL PERSPECTIVE

(2016) Theingi Tiffany Win et al.   Circulation-Heart Failure

Short-Chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes

(2016) Jiamiao Hu et al.   ENDOCRINOLOGY

In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure: results from the ESC-HFA Heart Failure Long-Term Registry

(2016) Giovanni Targher et al.   EUROPEAN JOURNAL OF HEART FAILURE

Mast cell proteases as pharmacological targets

(2016) George H. Caughey   EUROPEAN JOURNAL OF PHARMACOLOGY

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice

(2016) Satoko Hanatani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

(2016) Eef Boets et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Cardiac-Specific Deletion of thePdha1Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

(2016) Wanqing Sun et al.   TOXICOLOGICAL SCIENCES

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

The Nutritional Value and Health Benefits of Chickpeas and Hummus

(2016) Taylor Wallace et al.   Nutrients

Pathogenic Gut Flora in Patients With Chronic Heart Failure

(2016) Evasio Pasini et al.   JACC-Heart Failure

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

(2016) Constantijn Franssen et al.   JACC-Heart Failure

SCFA transport in rat duodenum

(2015) Izumi Kaji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Evidence of autoantibodies against cardiac troponin I and sarcomeric myosin in peripartum cardiomyopathy

(2015) Arash Haghikia et al.   BASIC RESEARCH IN CARDIOLOGY

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart FailureCLINICAL PERSPECTIVE

(2015) Tania Nevers et al.   Circulation-Heart Failure

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

(2015) Sarah Forbes et al.   DIABETES

Role of T-cells in myocardial infarction

(2015) Ulrich Hofmann et al.   EUROPEAN HEART JOURNAL

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

(2014) Tracey McLaughlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Role of Monocarboxylate Transporters in Drug Delivery to the Brain

(2014) Nisha Vijay et al.   CURRENT PHARMACEUTICAL DESIGN

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

(2014) Nicole Reichardt et al.   ISME Journal

Intestinal Blood Flow in Patients With Chronic Heart Failure

(2014) Anja Sandek et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation

(2014) E.C. Aguilar et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data

(2014) M. Vital et al.   mBio

Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis

(2014) G Frost et al.   Nutrition & Diabetes

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes

(2014) John M. Rumberger et al.   PeerJ

Propionic and butyric acids, formed in the caecum of rats fed highly fermentable dietary fibre, are reflected in portal and aortic serum

(2013) Greta Jakobsdottir et al.   BRITISH JOURNAL OF NUTRITION

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: humoral activation, a potential contributor of disease progression

(2013) K. A. Youker et al.   EUROPEAN HEART JOURNAL

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

(2013) Yasmine Zouggari et al.   NATURE MEDICINE

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Metabolic Rates of ATP Transfer Through Creatine Kinase (CK Flux) Predict Clinical Heart Failure Events and Death

(2013) P. A. Bottomley et al.   Science Translational Medicine

GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle

(2012) Lauren Aerni-Flessner et al.   Cardiovascular Diabetology

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity

(2012) Lan He et al.   CIRCULATION

Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation

(2012) Jun Mori et al.   Circulation-Heart Failure

Targeting myocardial substrate metabolism in heart failure: potential for new therapies

(2012) Hossein Ardehali et al.   EUROPEAN JOURNAL OF HEART FAILURE

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Fermentable Carbohydrate Alters Hypothalamic Neuronal Activity and Protects Against the Obesogenic Environment

(2012) Jelena Anastasovska et al.   Obesity

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Insulin Resistance and Heart Failure

(2012) Annayya R. Aroor et al.   Heart Failure Clinics

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac mast cells: the centrepiece in adverse myocardial remodelling

(2010) S. P. Levick et al.   CARDIOVASCULAR RESEARCH

The Th17/Treg imbalance exists in patients with heart failure with normal ejection fraction and heart failure with reduced ejection fraction

(2010) Na Li et al.   CLINICA CHIMICA ACTA

Dissecting thein VivoMetabolic Potential of Two Human Gut Acetogens

(2010) Federico E. Rey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FFA-Induced Adipocyte Inflammation and Insulin Resistance: Involvement of ER Stress and IKKβ Pathways

(2010) Ping Jiao et al.   Obesity

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Neutrophilia Predicts Death and Heart Failure After Myocardial Infarction

(2009) Adelaide M. Arruda-Olson et al.  

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene

(2009) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Targeted GLUT-4 deficiency in the heart induces cardiomyocyte hypertrophy and impaired contractility linked with Ca2+ and proton flux dysregulation

(2009) Andrea A. Domenighetti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy

(2009) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle

(2008) Jane Shearer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumor Necrosis Factor-α and Mortality in Heart Failure

(2008) Shannon M. Dunlay et al.   CIRCULATION

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

(2008) Andrew J. Murray et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY