Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

(2020) Barbora Vyhlídalová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

(2020) Laura Wrzosek et al.   GUT

The gut microbiota–brain axis in behaviour and brain disorders

(2020) Livia H. Morais et al.   NATURE REVIEWS MICROBIOLOGY

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

(2020) Bruno Lamas et al.   Science Translational Medicine

Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine

(2020) Zdeněk Dvořák et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

(2020) Wenjing Yang et al.   Nature Communications

Gut microbiota-derived metabolites as central regulators in metabolic disorders

(2020) Allison Agus et al.   GUT

Tryptophan Metabolism as a Pharmacological Target

(2020) Morgane Modoux et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

(2019) Ludovica Marinelli et al.   Scientific Reports

To boldly go where no cell has gone before

(2019) Ashley York   NATURE REVIEWS MICROBIOLOGY

Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk

(2019) Rachel Fellows et al.   Molecular Metabolism

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

(2018) Junduo Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor

(2018) Martina Stepankova et al.   MOLECULAR PHARMACOLOGY

The fecal metabolome as a functional readout of the gut microbiome

(2018) Jonas Zierer et al.   NATURE GENETICS

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR

(2018) Christopher Manzella et al.   Scientific Reports

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

(2018) Camille Martin-Gallausiaux et al.   Frontiers in Immunology

Validation of a global quantitative analysis methodology of tryptophan metabolites in mice using LC-MS

(2018) Antoine Lefèvre et al.   TALANTA

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

(2017) Un-Ho Jin et al.   Scientific Reports

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

(2016) Roman M. Stilling et al.   NEUROCHEMISTRY INTERNATIONAL

Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism

(2016) Agata Korecka et al.   npj Biofilms and Microbiomes

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

(2013) Theresa Alenghat et al.   NATURE

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

(2012) E. Wincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome

(2012) Mitsuharu Matsumoto et al.   Scientific Reports

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE