FoxP3 in T reg cell biology: a molecular and structural perspective

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

(2019) Catherine Konopacki et al.   NATURE IMMUNOLOGY

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

(2019) Veerle Fleskens et al.   Cell Reports

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis

(2019) Qiao Su et al.   JOURNAL OF AUTOIMMUNITY

Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

(2018) Anusara Daenthanasanmak et al.   BLOOD

Ring finger protein 31–mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function

(2018) Fuxiang Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation

(2015) Guoping Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination

(2015) Yixia Zhao et al.   JOURNAL OF IMMUNOLOGY

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions

(2015) Yongheng Chen et al.   NUCLEIC ACIDS RESEARCH

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation

(2014) Zhiyuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

(2014) Samik Basu et al.   JOURNAL OF IMMUNOLOGY

Isoform-Specific Inhibition of ROR -Mediated Transcriptional Activation by Human FOXP3

(2014) J. Du et al.   JOURNAL OF IMMUNOLOGY

Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

(2014) Yan Xiao et al.   Cell Reports

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

(2013) Zuojia Chen et al.   IMMUNITY

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

(2013) Jorg van Loosdregt et al.   IMMUNITY

Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2

(2013) Peter A. Morawski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial

(2013) Sung Won Choi et al.   LANCET ONCOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Phosphorylation of FOXP3 by LCK Downregulates MMP9 Expression and Represses Cell Invasion

(2013) Kumiko Nakahira et al.   PLoS One

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells

(2012) Guoping Deng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes

(2012) Jaime Darce et al.   IMMUNITY

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

(2012) Matthew L. Bettini et al.   IMMUNITY

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Cyclin-Dependent Kinase 2 Controls Peripheral Immune Tolerance

(2012) N. Chunder et al.   JOURNAL OF IMMUNOLOGY

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms

(2012) U. H. Beier et al.   Science Signaling

Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function

(2012) Xiaomin Song et al.   Cell Reports

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells

(2011) Ulf H Beier et al.   CURRENT OPINION IN IMMUNOLOGY

CD4+CD25lowGITR+ cells: A novel human CD4+ T-cell population with regulatory activity

(2011) Rodolfo Bianchini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

(2011) Hozefa S. Bandukwala et al.   IMMUNITY

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3

(2009) Wayne W. Hancock et al.   PLoS One

Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells

(2009) F. Pan et al.   SCIENCE

FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity

(2008) Zhaocai Zhou et al.   IMMUNOLOGIC RESEARCH

TGF-  and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3

(2008) A. Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA