Role of Diet–Microbiome Interaction in Gastrointestinal Disorders and Strategies to Modulate Them with Microbiome-Targeted Therapies

Global prevalence and burden of meal-related abdominal pain

(2022) Esther Colomier et al.   BMC Medicine

Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet, and the Gluten-Free Diet

(2022) Anupam Rej et al.   Clinical Gastroenterology and Hepatology

Consumption of Yeast-Fermented Wheat and Rye Breads Increases Colitis and Mortality in a Mouse Model of Colitis

(2022) Julia Zimmermann et al.   DIGESTIVE DISEASES AND SCIENCES

Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø

(2022) Catherine Dong et al.   Journal of Crohns & Colitis

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome

(2022) Adam L. Edwinson et al.   Nature Microbiology

A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!

(2022) Arezina Kasti et al.   Microorganisms

Adherence to the Mediterranean Diet Improved Clinical Scores and Inflammatory Markers in Children with Active Inflammatory Bowel Disease: A Randomized Trial

(2022) Doaa El Amrousy et al.   Journal of Inflammation Research

Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients

(2022) Heather K. Armstrong et al.   GASTROENTEROLOGY

Local immune response to food antigens drives meal-induced abdominal pain

(2021) Javier Aguilera-Lizarraga et al.   NATURE

Synbiotics improve clinical indicators of ulcerative colitis: systematic review with meta-analysis

(2021) Marcos Natal Rufino et al.   NUTRITION REVIEWS

Direct impact of commonly used dietary emulsifiers on human gut microbiota

(2021) Sabrine Naimi et al.   Microbiome

A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn’s Disease

(2021) James D. Lewis et al.   GASTROENTEROLOGY

n-6 High Fat Diet Induces Gut Microbiome Dysbiosis and Colonic Inflammation

(2021) Ornella I. Selmin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa

(2021) Yoshinori Hanawa et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study

(2021) Neeraj Narula et al.   BMJ-British Medical Journal

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

(2021) María Chaparro et al.   Journal of Clinical Medicine

Probiotics, Prebiotics, and Synbiotics in the Irritable Bowel Syndrome Treatment: A Review

(2021) Agnieszka Chlebicz-Wójcik et al.   Biomolecules

Association of Coffee and Caffeine Intake With Irritable Bowel Syndrome in Adults

(2021) Glareh Koochakpoor et al.   Frontiers in Nutrition

Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer

(2021) Rekha Jalandra et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada

(2021) Jasbir Dhaliwal et al.   Clinical Epidemiology

High FODMAP diet causes barrier loss via lipopolysaccharide-mediated mast cell activation

(2021) Prashant Singh et al.   JCI Insight

Dietary Intake of Total Carbohydrates, Sugar and Sugar-Sweetened Beverages, and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

(2021) Zeinab Khademi et al.   Frontiers in Nutrition

Novel findings of the association between gut microbiota–derived metabolite trimethylamine N-oxide and inflammation: results from a systematic review and dose-response meta-analysis

(2020) Mahdieh Abbasalizad Farhangi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Multidimensional Impact of Mediterranean Diet on IBD Patients

(2020) Fabio Chicco et al.   INFLAMMATORY BOWEL DISEASES

Gut Microbiota Metabolism and Interaction with Food Components

(2020) Pamela Vernocchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbiota in Celiac Disease: Is There Any Role for Probiotics?

(2020) Francesco Pecora et al.   Frontiers in Immunology

Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study

(2020) Zelei Miao et al.   DIABETES CARE

AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders

(2020) Geoffrey A. Preidis et al.   GASTROENTEROLOGY

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome—A Randomized Double-Blind, Placebo-Controlled Study

(2020) Barbara Skrzydło-Radomańska et al.   Nutrients

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

(2020) Natalia Arias et al.   Nutrients

Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome

(2020) Ruben A.T. Mars et al.   CELL

Epidemiology, Presentation, and Diagnosis of Celiac Disease

(2020) Benjamin Lebwohl et al.   GASTROENTEROLOGY

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

(2020) Bruno Lamas et al.   Science Translational Medicine

The hidden hazardous effects of stevia and sucralose consumption in male and female albino mice in comparison to sucrose

(2020) Alyaa Farid et al.   SAUDI PHARMACEUTICAL JOURNAL

Altered gene expression signatures by calcitonin gene‐related peptide promoted mast cell activity in the colon of stress‐induced visceral hyperalgesia mice

(2020) Hanliang Sun et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of synbiotic therapy in mild-to-moderately active ulcerative colitis: A randomized placebo-controlled study

(2019) Hulya Kamarli Altun et al.   Turkish Journal of Gastroenterology

Dietary polyunsaturated fatty acids promote neutrophil accumulation in spleen by altering chemotaxis and delaying cell death

(2019) Sara L. Svahn et al.   INFECTION AND IMMUNITY

Celiac disease: a comprehensive current review

(2019) Giacomo Caio et al.   BMC Medicine

Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome

(2019) Mohd Fyzal Bahrudin et al.   DIGESTIVE DISEASES AND SCIENCES

Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial

(2019) Arie Levine et al.   GASTROENTEROLOGY

Food Preservatives Induce Proteobacteria Dysbiosis in Human-Microbiota Associated Nod2-Deficient Mice

(2019) Hrncirova et al.   Microorganisms

Irritable Bowel Syndrome Subtypes: New Names for Old Medical Conditions

(2019) Simona Grad  et al.   DIGESTIVE DISEASES

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis

(2018) Daniel So et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

(2018) Yogesh Bhattarai et al.   Cell Host & Microbe

Eicosapentaenoic Acid Reduces Fecal Levels of Calprotectin and Prevents Relapse in Patients With Ulcerative Colitis

(2018) Eleonora Scaioli et al.   Clinical Gastroenterology and Hepatology

Effects of Prebiotics vs a Diet Low in Fodmaps in Patients with Functional Gut Disorder

(2018) Jose-Walter Huaman et al.   GASTROENTEROLOGY

Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice

(2018) Sean R. Llewellyn et al.   GASTROENTEROLOGY

Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice

(2018) Liang Chi et al.   MOLECULES

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Systematic Review and Meta-Analysis Evaluating the Efficacy of a Gluten-Free Diet and a Low FODMAPs Diet in Treating Symptoms of Irritable Bowel Syndrome

(2018) Joanna Dionne et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Gluten intake increases bacterial translocation and aggravates intestinal inflammation in experimental colitis

(2018) P.L. Menta et al.   CLINICAL NUTRITION

Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor-nerve growth factor-transient receptor potential vanilloid 1 axis

(2018) Wen-Ting Li et al.   FASEB JOURNAL

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects

(2018) Tim J. Sloan et al.   PLoS One

5-HT3 receptor signaling in serotonin transporter-knockout rats: a female sex-specific animal model of visceral hypersensitivity

(2018) Nadine El-Ayache et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Yogurt and other fermented foods as sources of health-promoting bacteria

(2018) Car Reen Kok et al.   NUTRITION REVIEWS

Lactose Intolerance, Dairy Avoidance, and Treatment Options

(2018) Andrew Szilagyi et al.   Nutrients

A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial

(2017) Heidi Maria Staudacher et al.   GASTROENTEROLOGY

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

(2017) Gilaad G. Kaplan et al.   GASTROENTEROLOGY

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota

(2017) Henry Watson et al.   GUT

Dietary fiber in irritable bowel syndrome (Review)

(2017) Magdy El-Salhy et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

(2017) Lulu Shen et al.   JOURNAL OF LIPID RESEARCH

Beverage consumption and risk of ulcerative colitis

(2017) Jia-Yan Nie et al.   MEDICINE

G protein-coupled estrogen receptor and estrogen receptor ligands regulate colonic motility and visceral pain

(2017) M. Zielińska et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease

(2017) Natalia Pedersen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review

(2017) Amber MacLellan et al.   Nutrients

Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice

(2017) Takashi Uebanso et al.   Nutrients

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

(2017) Warren N. D’Souza et al.   PLoS One

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

(2016) Karolina Skagen et al.   ATHEROSCLEROSIS

Efficacy of a Gluten-Free Diet in Subjects With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/8 Genotype

(2016) Imran Aziz et al.   Clinical Gastroenterology and Hepatology

Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity

(2016) Alberto Caminero et al.   GASTROENTEROLOGY

α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABA B receptors

(2016) Joel Castro et al.   GUT

Fermentable Carbohydrate Restriction (Low FODMAP Diet) in Clinical Practice Improves Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease

(2016) Alexis C. Prince et al.   INFLAMMATORY BOWEL DISEASES

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

(2016) Antoine Racine et al.   INFLAMMATORY BOWEL DISEASES

Early Changes in Microbial Community Structure Are Associated with Sustained Remission After Nutritional Treatment of Pediatric Crohnʼs Disease

(2016) Katherine A. Dunn et al.   INFLAMMATORY BOWEL DISEASES

Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial

(2016) Bojana Bogovič Matijašić et al.   JOURNAL OF DAIRY SCIENCE

Effect of n-3 fatty acids on the expression of inflammatory genes in THP-1 macrophages

(2016) Bénédicte Allam-Ndoul et al.   Lipids in Health and Disease

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study

(2016) F. Azpiroz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Interplay between bile acid metabolism and microbiota in irritable bowel syndrome

(2016) M. Dior et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome

(2016) E. Niv et al.   Nutrition & Metabolism

The role of exclusive enteral nutrition in the management of orofacial granulomatosis in children

(2016) Mohamed Mutalib et al.   World Journal of Pediatrics

Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis

(2016) Dawn M. Wiese et al.   PLoS One

La nutrición enteral exclusiva continua siendo el tratamiento de primera línea en la enfermedad de Crohn pediátrica en la era de los biológicos

(2015) V.M. Navas-López et al.   ANALES DE PEDIATRIA

Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel

(2015) Neelendu Dey et al.   CELL

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

(2015) Francesca De Filippis et al.   GUT

Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome

(2015) A. Dlugosz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Dietary fiber intake reduces risk of inflammatory bowel disease: result from a meta-analysis

(2015) Xiaoqin Liu et al.   NUTRITION RESEARCH

The Overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Clinical Dilemma

(2015) Archita Makharia et al.   Nutrients

The Effect of Fiber Supplementation on Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

(2014) Paul Moayyedi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease

(2014) Irina Costea et al.   GASTROENTEROLOGY

A High-Fiber Diet May Improve Bowel Function and Health-Related Quality of Life in Patients With Crohn Disease

(2014) Carol S. Brotherton et al.   Gastroenterology Nursing

Prevalence of a Gluten-free Diet and Improvement of Clinical Symptoms in Patients with Inflammatory Bowel Diseases

(2014) Hans H. Herfarth et al.   INFLAMMATORY BOWEL DISEASES

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice

(2013) Sanjoy Ghosh et al.   BRITISH JOURNAL OF NUTRITION

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

(2013) Emma P. Halmos et al.   GASTROENTEROLOGY

Geographical variability and environmental risk factors in inflammatory bowel disease

(2013) Siew C Ng et al.   GUT

Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity

(2013) Daniel S. Pearl et al.   Journal of Crohns & Colitis

Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan

(2013) G. Li et al.   MICROBIOLOGY-SGM

Use of exclusive enteral nutrition in adults with Crohn’s disease: A review

(2013) Catherine L Wall   WORLD JOURNAL OF GASTROENTEROLOGY

Trends in Overall and Cause-Specific Mortality Among Patients With Inflammatory Bowel Disease From 1982 to 2010

(2012) Tine Jess et al.   Clinical Gastroenterology and Hepatology

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

A randomised clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life

(2012) Carmelina Cappello et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Enteral nutrition to suppress postoperative Crohn’s disease recurrence: a five-year prospective cohort study

(2012) Takayuki Yamamoto et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Crohn's Disease-Associated Adherent-Invasive Escherichia coli Adhesion Is Enhanced by Exposure to the Ubiquitous Dietary Polysaccharide Maltodextrin

(2012) Kourtney P. Nickerson et al.   PLoS One

Effect of composite yogurt enriched with acacia fiber andBifidobacterium lactis

(2012) Yang Won Min   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature

(2011) Jason K Hou et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Synbiotics for inflammatory bowel disease: useful in adults but problematic in paediatrics

(2011) R. Hansen et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Effect of oligofructose-enriched inulin (OF-IN) on bacterial composition and disease activity of patients with Crohn's disease: results from a double-blinded randomised controlled trial: Table 1

(2011) Marie Joossens et al.   GUT

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease

(2011) J. L. Benjamin et al.   GUT

Effects of an oral supplementation of germinated barley foodstuff on serum tumour necrosis factor- , interleukin-6 and -8 in patients with ulcerative colitis

(2011) Z. Faghfoori et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study

(2010) Prévost Jantchou et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers

(2010) C. L. Roberts et al.   GUT

Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet

(2010) Mitsuro Chiba   WORLD JOURNAL OF GASTROENTEROLOGY

Tryptophan synthase: a mine for enzymologists

(2009) Samanta Raboni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

(2009) Suwebatu T. Odunsi–Shiyanbade et al.   Clinical Gastroenterology and Hepatology

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study

(2009)   GUT

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

(2009) d. keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The role of colonic metabolism in lactose intolerance

(2008) T. He et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Reduction of dietary poorly absorbed short-chain carbohydrates (FODMAPs) improves abdominal symptoms in patients with inflammatory bowel disease—a pilot study

(2008) Richard B. Gearry et al.   Journal of Crohns & Colitis

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinated barley foodstuff ameliorates inflammation in mice with colitis through modulation of mucosal immune system

(2008) Osamu Kanauchi et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY