Article
Nutrition & Dietetics
Darja Urlep, Rok Orel, Patricija Kunstek, Evgen Benedik
Summary: This study evaluated the clinical and endoscopic rates of remission in children with active Crohn's disease (CD) treated with partial enteral nutrition (PEN) combined with a modified Crohn's disease exclusion diet (mCDED). The study found that PEN + mCDED could potentially induce clinical and endoscopic remission in pediatric CD patients. The results provide evidence for the use of PEN + mCDED in the treatment of pediatric CD.
Article
Gastroenterology & Hepatology
Susanna Meade, Kamal V. Patel, Raphael P. Luber, Dearbhaile O'Hanlon, Andra Caracostea, Polychronis Pavlidis, Sailish Honap, Cheran Anandarajah, Nyree Gryffin, Sebastian Zeki, Shuvra Ray, Joel Mawdsley, Mark A. Samaan, Simon H. Anderson, Amir Darakhshan, Katie Adams, Andrew Williams, Jeremy D. Sanderson, Miranda Lomer, Peter M. Irving
Summary: This study found that pre-operative oral enteral nutrition in patients with Crohn's disease undergoing surgery was associated with reduced postoperative complications, particularly non-surgical complications and infectious complications.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Nutrition & Dietetics
Giacomo Caio, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, Giorgio Zoli
Summary: Crohn's disease is a chronic inflammatory bowel disease that can cause malnutrition in a significant percentage of patients, highlighting the importance of diet in managing the condition. This review aims to cover recent findings in nutrition for CD treatment, including established diets, new nutritional theories, and advancements in areas like nutrigenomics.
Review
Biochemistry & Molecular Biology
Kawthar Boumessid, Frederick Barreau, Emmanuel Mas
Summary: Crohn's disease, an inflammatory bowel disease, is on the rise globally. Dietary therapy with Modulen(R), a formula enriched with polymeric TGF-beta 2, is recommended as a first-line option for inducing clinical remission and mucosal healing, especially for children. Further well-designed studies are needed to improve knowledge and optimize therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Kwangwoo Nam, Won Beom Jung, Seung Bum Lee, Jae Seung Soh, Song Soo Yang, Seok Won Jung
Summary: Treating perianal fistula in Korean Crohn's disease (CD) patients remains challenging, with a postoperative recurrence rate of 22%-28%. A study found a relatively high postoperative recurrence rate of 41.2% in Korean CD patients, but drug escalation therapy after the first surgery may help reduce the need for reoperation for perianal fistula.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Medicine, General & Internal
Roma Herman, Paulina Dumnicka, Stanislaw Pieczarkowski, Krzysztof Fyderek
Summary: Mucosal healing is the main treatment goal of Crohn's disease, and the Mucosal Inflammation Noninvasive Index (MINI) shows promise in distinguishing mucosal healing from inflammation. This study evaluated MINI in monitoring remissions induced by exclusive enteral nutrition in pediatric CD patients, and found that MINI is superior to fecal calprotectin in predicting disease relapse.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Lucia Gonzalez-Torres, Ana Moreno-Alvarez, Ana Estefania Fernandez-Lorenzo, Rosaura Leis, Alfonso Solar-Boga
Summary: This systematic review analyzed the effectiveness of partial enteral nutrition (PEN) as a remission induction therapy in Crohn's disease (CD). The results suggest that PEN combined with a highly restrictive diet seems to be as effective as exclusive enteral nutrition (EEN) in inducing CD remission, but further studies are needed to confirm this finding.
Article
Microbiology
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: This study investigated the changes in the intestinal microbiota of children with Crohn's disease (CD) before, during, and after exclusive enteral nutrition (EEN). Stool samples were collected at different time points and a molecular approach was used for analysis. The study found that the microbiota composition changed significantly after two months of EEN discontinuation and remained mostly unchanged over a year of follow-up.
Article
Gastroenterology & Hepatology
David I. F. Wands, Laura Gianolio, David C. Wilson, Richard Hansen, Iain Chalmers, Paul Henderson, Konstantinos Gerasimidis, Richard K. Russell
Summary: In pediatric patients with CD in Scotland, the usage rates of EEN have not changed over the past 7.5 years, except during the COVID-19 pandemic, despite an increase in biologic use. Combination induction has emerged as a new trend.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Nutrition & Dietetics
Stephanie Brown, Catherine L. Wall, Chris Frampton, Richard B. Gearry, Andrew S. Day
Summary: This study assessed the dietary intake and blood micronutrient status of children with CD compared to their healthy siblings, and found that both groups did not meet the recommended daily intakes for several micronutrients.
Article
Endocrinology & Metabolism
Jair G. Marques, Tobias Schwerd, Philip Bufler, Sibylle Koletzko, Berthold Koletzko
Summary: Exclusive enteral nutrition therapy leads to changes in the metabolic profile of pediatric Crohn's Disease patients, including a decrease in compounds related to diet and a bacterial metabolite. The reduction of phosphatidic acid metabolite PA(15:1/18:0) is correlated with disease activity. During exclusive enteral nutrition therapy, there is an increase in phosphatidylethanolamines and one lactosylceramide.
Review
Medicine, General & Internal
Kristy Iglay, Dimitri Bennett, Michael D. Kappelman, Kamika Reynolds, Molly Aldridge, Chitra Karki, Suzanne F. Cook
Summary: The study found that there is a lack of description of the disease burden of CD-related ECF in the literature, with varying clinical responses and high recurrence rates reported. Limited information is available on healthcare resource utilization and patient-reported outcomes for this specific population.
Article
Nutrition & Dietetics
Yao Lv, Yue Lou, Ana Liu, Qi Cheng, Gan Yang, Cuifang Xu, Youyou Luo, Jingan Lou, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen
Summary: Exclusive enteral nutrition (EEN) treatment can improve gut microbiome and bile acid (BA) metabolism of patients with Crohn's disease (CD). The study involved 27 newly diagnosed pediatric CD patients and 27 healthy controls. The findings suggest that EEN treatment can restore GM structure and secondary BA metabolism, and the abundance of Firmicutes bacteria and the balance of primary and secondary BAs are associated with CD severity and mucosal inflammation.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Heather C. Kaplan, Lisa Opipari-Arrigan, Jiabei Yang, Christopher H. Schmid, Christine L. Schuler, Shehzad A. Saeed, Kimberly L. Braly, Fandi Chang, Lauren Murphy, Cassandra M. Dodds, Mason Nuding, Hao Liu, Sheri Pilley, Julie Stone, Gisele Woodward, Nancy Yokois, Alka Goyal, Dale Lee, Ann Ming Yeh, Peter Lee, Benjamin D. Gold, Zarela Molle-Rios, R. Jeff Zwiener, Sabina Ali, Mallory Chavannes, Tiffany Linville, Ashish Patel, Travis Ayers, Mikelle Bassett, Brendan Boyle, Pablo Palomo, Sofia Verstraete, Jill Dorsey, Jess L. Kaplan, Steven J. Steiner, Kaylie Nguyen, Jennifer Burgis, David L. Suskind
Summary: Findings from a study consisting of 54 single-subject trials showed that SCD and MSCD performed similarly for most individuals, with less than 1% probability of a clinically meaningful difference in IBD symptoms between the two diets. Some individuals experienced improvements in symptoms and fecal calprotectin compared with their usual diet, while others did not.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Marialaura Cuomo, Alessandra Carobbio, Marina Aloi, Patrizia Alvisi, Claudia Banzato, Luca Bosa, Matteo Bramuzzo, Angelo Campanozzi, Giulia Catassi, Lorenzo D'Antiga, Monica Di Paola, Enrico Felici, Maria Teresa Fioretti, Simona Gatti, Francesco Graziano, Sara Lega, Paolo Lionetti, Antonio Marseglia, Massimo Martinelli, Francesca Musto, Naire Sansotta, Luca Scarallo, Giovanna Zuin, Lorenzo Norsa
Summary: Exclusive enteral nutrition is the first choice for inducing remission in pediatric Crohn's disease, but adherence to this treatment can be challenging for children. This study aimed to identify factors predictive of nonadherence and nonremission. The results showed that colonic involvement and high fecal calprotectin levels at diagnosis were associated with reduced adherence to exclusive enteral nutrition.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Paulo Gustavo Kotze, Bo Shen, Amy Lightner, Takayuki Yamamoto, Antonino Spinelli, Subrata Ghosh, Remo Panaccione
Article
Gastroenterology & Hepatology
Paulo Gustavo Kotze, Daniela Oliveira Magro, Carlos Augusto Real Martinez, Antonino Spinelli, Takayuki Yamamoto, Janindra Warusavitarne, Claudio Saddy Rodrigues Coy
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2018)
Article
Gastroenterology & Hepatology
James C. Glasbey, Ruth Blanco-Colino, Michael Kelly, Baljit Singh, Dmitri Nepogodiev, Aneel Bhangu, Thomas Pinkney, Tomas Poskus
COLORECTAL DISEASE
(2018)
Article
Gastroenterology & Hepatology
Nick Battersby, James C. Glasbey, Peter Neary, Ionut Negoi, Sivesh Kamarajah, Alessandro Sgro, Dmitri Nepogodiev, Aneel Bhangu, Thomas Pinkney, Matteo Frasson
COLORECTAL DISEASE
(2018)
Article
Gastroenterology & Hepatology
Aneel Bhangu Ana Maria Minaya-Bravo, Gaetano Gallo, James C. Glasbey, Sivesh Kamarajah, Dmitri Nepogodiev, Thomas Pinkney, Alaa El-Hussana
COLORECTAL DISEASE
(2018)
Article
Gastroenterology & Hepatology
Luis Sanchez-Guillen, Dmitri Nepogodiev, Emre Sivrikoz, Tim van Elst, Ana Minaya, Francesco Pata, James Glasbey, Thomas Pinkney, Aneel Bhangu
COLORECTAL DISEASE
(2018)
Article
Gastroenterology & Hepatology
James Glasbey, Anne van der Pool, Alexandra Rawlings, Luis Sanchez-Guillen, Sara Kuiper, Ionut Negoi, Nicolas Buchs, Dmitri Nepogodiev, Thomas Pinkney, Aneel Bhangu
COLORECTAL DISEASE
(2018)
Review
Hematology
Abbi R. Saniabadi, Tomotaka Tanaka, Takayuki Yamamoto, Wolfgang Kruis, Rodolfo Sacco
JOURNAL OF CLINICAL APHERESIS
(2019)
Review
Pharmacology & Pharmacy
Marjorie Argollo, Paulo Gustavo Kotze, Laura Lamonaca, Daniela Gilardi, Federica Furfaro, Takayuki Yamamoto, Silvio Danese
CURRENT DRUG TARGETS
(2019)
Review
Pharmacology & Pharmacy
Takayuki Yamamoto, Fabio Vieira Teixeira, Rogerio Saad-Hossne, Paulo Gustavo Kotze, Silvio Danese
CURRENT DRUG TARGETS
(2019)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Shinya Sugimoto, Hideo Suzuki, Yuichi Matsuno, Toshimitsu Araki, Hirotaka Shimizu, Ryohei Hayashi, Tomohiro Fukuda, Nobuhiro Nakamoto, Hideki Iijima, Shiro Nakamura, Masaharu Kataoka, Yuichi Tamura, Koichiro Tatsumi, Toshifumi Hibi, Yasuo Suzuki, Takanori Kanai, Yusuke Yoshimatsu, Po-sung Chu, Motoi Uchino, Kenji Watanabe, Atsushi Hirano, Motohiro Esaki, Yoshitaka Ueno, Takayuki Yamamoto, Koji Sawada, Kosaku Kawashima, Shunji Ishihara, Toshimitsu Araki, Shinichi Hashimoto, Junji Yokoyama, Shinya Ashizuka, Tatsuya Toyokawa, Hirotake Sakuraba, Kazuhiro Matsueda, Naoki Yoshimura, Naoki Ohmiya, Yoshiyuki Kayashima, Shunichi Yanai, Takayuki Matsumoto, Hiroyuki Kobayashi, Sachiko Nakajima, Tsutomu Nishida, Yoshiaki Takeuchi, Kenji Ina, Takuji Kawamura
JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Takayuki Yamamoto, Takahiro Shimoyama, Satoru Umegae, Paulo Gustavo Kotze
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2019)
Article
Surgery
Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Satoshi Okada, Soichiro Ishihara, Koji Morimoto, Rikisaburo Sahara, Kazuhiro Watanabe, Kouhei Fukushima, Kenichi Takahashi, Hideaki Kimura, Keiji Hirata, Tsunekazu Mizushima, Toshimitsu Araki, Masato Kusunoki, Riichiro Nezu, Sayumi Nakao, Michio Itabashi, Akira Hirata, Heita Ozawa, Takashi Ishida, Koji Okabayashi, Takayuki Yamamoto, Toshihiro Noake, Junya Arakaki, Yusuke Watadani, Hiroki Ohge, Ryo Futatsuki, Kazutaka Koganei, Akira Sugita, Daijiro Higashi, Kitaro Futami
Article
Gastroenterology & Hepatology
Makoto Naganuma, Shinya Sugimoto, Tomohiro Fukuda, Keiichi Mitsuyama, Taku Kobayashi, Naoki Yoshimura, Hidehisa Ohi, Shinji Tanaka, Akira Andoh, Naoki Ohmiya, Keiichiro Saigusa, Takayuki Yamamoto, Yuichi Morohoshi, Hitoshi Ichikawa, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Kenji Watanabe, Shinta Mizuno, Takayuki Abe, Yasuo Suzuki, Takanori Kanai, Makoto Naganuma, Shinya Sugimoto, Shinta Mizuno, Yoshihiro Nakazato, Tomohiro Fukuda, Toshiaki Teratani, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai, Hiroshi Yamasaki, Keiichi Mitsuyama, Taku Kobayashi, Takahiko Toyonaga, Masaru Nakano, Toshifumi Hibi, Naoki Yoshimura, Yoichi Sameshima, Hidehisa Ohi, Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, Shigeki Bamba, Akira Andoh, Mamoru Watanabe, Keiichiro Saigusa, Atsushi Nakazawa, Yuichi Morohoshi, Yuji Koike, Jin Imai, Hitoshi Ichikawa, Takahiro Shimoyama, Takayuki Yamamoto, Katsuyoshi Matsuoka, Ken Takeuchi, Yasuo Suzuki, Mitsuo Nagasaka, Naoki Ohmiya, Atsuo Kitano, Shinya Ashizuka, Haruhiko Inatsu, Kei Onodera, Hiroshi Nakase, Kazuya Kitamura, Kentaro Ikeya, Hiroyuki Hanai, Chikako Watanabe, Ryota Hokari, Fumihito Hirai, Yuji Naito, Namiko Hoshi, Fukunori Kinjo, Yo Ishiguro, Makoto Sasaki, Takayuki Matsumoto, Kenji Watanabe, Tadakazu Hisamatsu, Fumiya Sano, Rachel Roberts, Takayuki Abe, Wataru Suda, Masahira Hattori, Shinji Fukuda, Akiyoshi Hirayama
JOURNAL OF GASTROENTEROLOGY
(2020)
Letter
Gastroenterology & Hepatology
Takayuki Yamamoto, Paulo Gustavo Kotze
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)