Article
Multidisciplinary Sciences
Yutaro Masu, Yoshitake Kanazawa, Yoichi Kakuta, Yusuke Shimoyama, Motoyuki Onodera, Takeo Naito, Rintaro Moroi, Masatake Kuroha, Tomoya Kimura, Hisashi Shiga, Yoshitaka Kinouchi, Atsushi Masamune
Summary: In inflammatory bowel diseases (IBDs), the presence of Ig-coated bacteria in the intestine is associated with disease activity, with higher percentages of IgA and IgM-coated bacteria in IBD patients. Specific IgG subtypes coating bacteria were only found in IBD patients, and their levels correlated with disease activities in UC and CD patients. This suggests that analyzing Ig-coated bacteria and Ig subtypes using flow cytometry could provide useful indicators of disease activity and potential treatment targets for IBDs.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jorge L. Petro, Maria Carolina Fragozo-Ramos, Andres F. Milan, Juan C. Aristizabal, Jaime A. Gallo-Villegas, Juan C. Calderon
Summary: This cross-sectional study found that serum myonectin levels are lower in subjects with metabolic syndrome (MS) compared to those without MS. Serum myonectin is negatively correlated with the android/gynoid fat mass ratio, but not with lipid profile, free fatty acids, intramuscular lipid content, or insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paulina Krawiec, Elzbieta Pac-Kozuchowska
Summary: This study aimed to evaluate the level of serum elafin in children with inflammatory bowel disease (IBD) and its relationship with disease activity. The results showed that serum elafin levels were significantly elevated in children with IBD, especially during active phases. ROC analysis suggested that serum elafin could be a potential biomarker for ulcerative colitis.
Article
Nutrition & Dietetics
Jian He, Xiaobei Luo, Hongjie Xin, Qianwei Lai, Yuanping Zhou, Yang Bai
Summary: Omega-3 fatty acids have a protective effect against ulcerative colitis, while there is no causal relationship between other fatty acids and inflammatory bowel disease.
Article
Biochemistry & Molecular Biology
Zhiguo Li, Shan Zhang, Li Xu, Xuexun Fang, Youzhong Wan, Dahai Yu, Yi Guo
Summary: This study aimed to investigate the therapeutic effect and potential mechanism of tetrapeptide from maize (TPM) and probiotic treatment on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57BL/6J mice. The results indicated that TPM and probiotics reduced pro-inflammatory cytokine levels and restored the gut microbiota, effectively alleviating the adverse effects of UC. Furthermore, the combination of TPM and probiotics had a more pronounced effect.
Article
Nutrition & Dietetics
Arno R. Bourgonje, Laura A. Bolte, Lianne L. C. Vranckx, Lieke M. Spekhorst, Ranko Gacesa, Shixian Hu, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Janneke N. Samsom, Gerard Dijkstra, Rinse K. Weersma, Marjo J. E. Campmans-Kuijpers
Summary: This study aimed to investigate the association between dietary patterns and circulating inflammatory proteins in patients with inflammatory bowel disease (IBD). The results showed that a high-sugar diet was inversely associated with fibroblast growth factor-19 (FGF-19), while a Mediterranean-style diet was associated with higher FGF-19 levels. A diet characterized by high alcohol and coffee intake was positively associated with CCL11 levels and lower levels of IL-12B.
Article
Gastroenterology & Hepatology
Salvatori Silvia, Marafini Irene, Venuto Chiara, Laudisi Federica, Neri Benedetto, Lavigna Diletta, Franchin Martina, De Cristofaro Elena, Biancone Livia, Calabrese Emma, Giannarelli Diana, Giovanni Monteleone
Summary: Frailty is common in hospitalized patients with inflammatory bowel disease (IBD) and has been associated with an increased risk of adverse outcomes. This prospective study revealed that nearly one-fifth of IBD patients were frail, with active disease being an independent risk factor for the frail phenotype.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Microbiology
Wen-Hui Zhang, Ze-Yu Jin, Zhong-Hua Yang, Jia-Yi Zhang, Xiao-Han Ma, Jing Guan, Bao-Lin Sun, Xi Chen
Summary: This study aimed to evaluate the long-term efficacy and safety of fecal microbiota transplantation (FMT) from young UC patients as donors. The results showed that FMT is safe and effective for active UC patients who are nonresponsive to mesalazine or prednisone. FMT efficiently downregulated pro-inflammatory cytokines to ameliorate inflammation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alka A. Potdar, Shishir Dube, Takeo Naito, Katherine Li, Gregory Botwin, Talin Haritunians, Dalin Li, David Casero, Shaohong Yang, Janine Bilsborough, Jacqueline G. Perrigoue, Lee A. Denson, Mark Daly, Stephan R. Targan, Phillip Fleshner, Jonathan Braun, Subra Kugathasan, Thaddeus S. Stappenbeck, Dermot P. B. McGovern
Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.
Article
Nutrition & Dietetics
Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, Rene-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier, Luca Semerano
Summary: This study aimed to investigate the relationship between serum lipid profiles and disease activity in patients with early rheumatoid arthritis (RA). The study found that a serum lipid profile rich in n-3 fatty acids was independently associated with persistently reduced disease activity, while a profile rich in n-6 fatty acids was associated with lower disease activity.
Article
Biochemistry & Molecular Biology
Sara Deleu, Kaline Arnauts, Lowie Deprez, Kathleen Machiels, Marc Ferrante, Geert R. B. Huys, Johan M. M. Thevelein, Jeroen Raes, Severine Vermeire
Summary: Short-chain fatty acids and their bacterial producers are gaining increasing attention in inflammatory bowel diseases. Acetate, although less studied compared to butyrate, shows potential in being less toxic to epithelial cells, stimulating butyrate-producing bacteria, and having anti-inflammatory and barrier-protective properties. In a study using organoid-based monolayer cultures from ulcerative colitis patients, high acetate concentrations were found to improve epithelial resistance, decrease pro-inflammatory markers, and enhance barrier gene expression. These findings suggest that acetate may offer a promising approach for managing barrier defects and inflammation in IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P. B. McGovern
Summary: This study presents a novel molecular-based prediction model that combines genetics, serum biomarkers, and smoking information to assist in the diagnosis of Crohn's disease and ulcerative colitis. The joint model explains approximately 46% of phenotypic variation, with genetics making unique contributions to distinguishing disease subtypes and smoking status potentially not being an effective biomarker.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Letter
Cardiac & Cardiovascular Systems
Daniel E. Clark, Amar Parikh, Jeffrey M. Dendy, Alex B. Diamond, Kristen George-Durrett, Frank A. Fish, James C. Slaughter, Warne Fitch, Sean G. Hughes, Jonathan H. Soslow
Article
Biochemistry & Molecular Biology
Dina Polosukhina, Kshipra Singh, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Dana M. Hardbower, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson, Lori A. Coburn
Summary: The study found that CCL11 is involved in the pathogenesis of DSS-induced colitis and contributes to colon tumorigenesis. Mice lacking CCL11 exhibited less intestinal damage and reduced cancer development in experiments, indicating the important role of CCL11 in the development of colitis and colon cancer.
Letter
Cardiac & Cardiovascular Systems
Jonathan H. Soslow, Justin Godown, David W. Bearl, Kimberly Crum, James C. Slaughter, Kristen George-Durrett, Kak-Chen Chan, Maryanne Chrisant, Debra Dodd, Lazaro Hernandez
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Gastroenterology & Hepatology
Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Jordan L. Finley, Thaddeus M. Smith, Kara M. McNamara, Kshipra Singh, Johanna C. Sierra, Alberto G. Delgado, Paula B. Luis, Claus Schneider, M. Kay Washington, M. Blanca Piazuelo, Shilin Zhao, Lori A. Coburn, Keith T. Wilson
Summary: The study demonstrates that Spd treatment can reduce colitis and carcinogenesis, reversing the effects of SMOX deficiency on colitis and CAC, reducing tumor development, and modulating the microbiome.
Article
Medicine, Research & Experimental
Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson
Summary: Macrophages play a crucial role in the inflammatory response to Helicobacter pylori infection. Induction of cystathionine gamma-lyase (CTH) in macrophages by H. pylori promotes persistent inflammation. CTH deficiency results in altered macrophage function and metabolism, leading to decreased gastric inflammation.
Article
Pediatrics
Wubishet Belay, Justin Godown, Kak-Chen Chan, David W. Bearl, Kristen George-Durrett, James C. Slaughter, Kimberly Crum, Debra A. Dodd, Maryanne Chrisant, Lazaro Hernandez, Jonathan Soslow
Summary: This study suggests that cardiac magnetic resonance can be used as a noninvasive method to assess signs of diastolic dysfunction after pediatric heart transplantation. Peak filling rate, global longitudinal and circumferential strain, and left atrial volumes were correlated with pulmonary capillary wedge pressure and could be used to estimate filling pressures through modeling.
PEDIATRIC TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Summary: Stomach cancer is a leading cause of cancer death, primarily caused by Helicobacter pylori infection, which induces inflammation and DNA damage. 2-hydroxybenzylamine (2-HOBA), derived from buckwheat seeds, is effective in reducing gastritis, gastric dysplasia, and carcinogenesis caused by H. pylori infection in mice and gastric epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan H. Soslow, Meng Xu, James C. Slaughter, Kimberly Crum, Jacob A. Kaslow, Kristen George-Durrett, Frank J. Raucci Jr, James D. Wilkinson, Linda H. Cripe, Kan N. Hor, Christopher F. Spurney, Larry W. Markham
Summary: This study evaluated the rate of change for cardiac magnetic resonance and blood biomarkers and identified the measures associated with all-cause mortality in Duchenne muscular dystrophy (DMD). The results showed that LV ejection fraction, indexed LV volumes, circumferential strain, late gadolinium enhancement full width half maximum, and NT-proBNP were associated with all-cause mortality in DMD and may be the best end points for use in cardiovascular therapeutic trials. The study also reported the change over time of cardiac magnetic resonance and blood biomarkers.
CIRCULATION-HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Summary: This study found that isolevuglandins (isoLGs), formed from lipid peroxidation, covalently bind with amine-containing macromolecules in colonic epithelial cells of colorectal cancer (CRC) patients. The natural compound 2-hydroxybenzylamine (2-HOBA), a scavenger of electrophiles, was shown to reduce isoLG adduct levels, tumorigenesis, and oncogenic NRF2 activation in CRC models. In addition, 2-HOBA attenuated the growth of human CRC cells in animal models.
Article
Cell Biology
Justin Jacobse, Rachel E. Brown, Jing Li, Jennifer M. Pilat, Ly Pham, Sarah P. Short, Christopher T. Peek, Andrea Rolong, M. Kay Washington, Ruben Martinez-Barricarte, Mariana X. Byndloss, Catherine Shelton, Janet G. Markle, Yvonne L. Latour, Margaret M. Allaman, James E. Cassat, Keith T. Wilson, Yash A. Choksi, Christopher S. Williams, Ken S. Lau, Charles R. Flynn, Jean-Laurent Casanova, Edmond H. H. M. Rings, Janneke N. Samsom, Jeremy A. Goettel
Summary: The cytokine IL-23 plays a role in the development of inflammatory bowel disease (IBD). IL-23R is highly expressed in intestinal Tregs, but its effect on Tregs remains unknown. This study shows that IL-23 reduces the frequency and suppressive function of colonic Tregs and that mice lacking IL-23R in Tregs have increased Treg frequency and advantages during inflammation. Furthermore, IL-23 antagonizes the liver X receptor pathway, cellular cholesterol transporter Abca1, and increases Treg apoptosis. These findings suggest that IL-23 negatively regulates intestinal Tregs, potentially promoting chronic inflammation in patients with IBD.
Article
Gastroenterology & Hepatology
Yvonne L. L. Latour, Margaret M. M. Allaman, Daniel P. P. Barry, Thaddeus M. M. Smith, Kamery J. J. Williams, Kara M. M. McNamara, Justin Jacobse, Jeremy A. A. Goettel, Alberto G. G. Delgado, M. Blanca Piazuelo, Shilin Zhao, Alain P. P. Gobert, Keith T. T. Wilson
Summary: Lack of talin-1 in intestinal epithelial cells increases susceptibility to colonic disease caused by pathogenic Escherichia coli, leading to decreased survival, increased colonization, colon weight, and histologic colitis. Loss of talin-1 in colonic epithelial cells impairs recruitment and activation of T cells, exacerbating colonic mucosal hyperplasia and cell crowding in the glands.
Article
Immunology
Yvonne L. Latour, Johanna C. Sierra, Kara M. McNamara, Thaddeus M. Smith, Paula B. Luis, Claus Schneider, Alberto G. Delgado, Daniel P. Barry, Margaret M. Allaman, Wade Calcutt, Kevin L. Schey, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson
Summary: Colonization by Helicobacter pylori is associated with gastric diseases, and the interplay of the host response and the pathogen affects the outcome. Polyamines have been found to regulate H. pylori-induced inflammation. Specific deletion of the ODC gene in gastric epithelial cells can reduce gastritis, attenuate epithelial proliferation, and downregulate the expression of immune mediators induced by H. pylori.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek
Summary: This study reveals that Helicobacter pylori enhances gastric injury under conditions of iron deficiency and that this phenomenon is closely associated with altered bile acid metabolism. Deoxycholic acid (DCA) is identified as a carcinogenic bile acid that can further exacerbate gastric injury and promote the translocation of the H. pylori oncoprotein CagA into host cells. Conversely, the use of bile acid sequestrants can attenuate H. pylori-induced injury. Furthermore, cumulative use of bile acid sequestrants is significantly associated with a reduced risk of gastric cancer in human populations. These findings demonstrate the importance of bile acid metabolism in H. pylori-induced gastric injury and carcinogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Shunxing Bao, Sophie Chiron, Yucheng Tang, Cody N. Heiser, Austin N. Southard-Smith, Ho Hin Lee, Marisol A. Ramirez, Yuankai Huo, Mary K. Washington, Elizabeth A. Scoville, Joseph T. Roland, Qi Liu, Ken S. Lau, Keith T. Wilson, Lori A. Coburn, Bennett A. Landman
Summary: The Gut Cell Atlas (GCA) initiative aims to create a reference platform for understanding the human gut, specifically focusing on Crohn's disease. It uses the REDCap system to securely track and analyze data, addressing challenges of integrating various types of health data for research and analysis.
MEDICAL IMAGING 2021: IMAGING INFORMATICS FOR HEALTHCARE, RESEARCH, AND APPLICATIONS
(2021)