Journal
INFECTION AND IMMUNITY
Volume 87, Issue 8, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00270-19
Keywords
apoptosis; chemotaxis; dietary fatty acids; neutrophils; polyunsaturated fatty acids
Categories
Funding
- Swedish Research Council [2017-02186, K2013-54X-09894-19-3]
- Swedish Society of Medicine
- Magnus Bergvall Foundation
- Langmanska Kulturfonden
- Stiftelsen Gamla Trotjanarinnor
- Lars Hiertas Foundation
- Ake Wiberg Foundation
- Stiftelsen Tornspiran
- W. and M. Lundgren Foundation
- Kungliga Vetenskaps-och Vitterhetssamhallet i Goteborg
- Adlerbertska Stiftelsen
- Sahlgrenska Center for Cardiovascular, Metabolic Research (CMR) - Swedish Strategic Foundation [A305: 188]
- EC [Full4Health FP7-KBBE-2010-4-266408]
- Swedish Research Council [2017-02186] Funding Source: Swedish Research Council
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Neutrophils are the most abundant circulating leukocytes in humans and are essential for the defense against invading pathogens. Like many other cells of an organism, neutrophils can be highly influenced by the diet. We have previously described that mice fed a high-fat diet rich in polyunsaturated fatty acids (HFD-P) present a higher frequency of neutrophils in bone marrow than mice fed a high-fat diet rich in saturated fatty acids (HFD-S). Interestingly, such an increase correlated with improved survival against bacterium-induced sepsis. In this study, we aimed to investigate the effects of dietary polyunsaturated and saturated fatty acids on neutrophil homeostasis. We found that HFD-P specifically induced the accumulation of neutrophils in the marginal pools of the spleen and liver. The accumulation of neutrophils in the spleen was a result of a dual effect of polyunsaturated fatty acids on neutrophil homeostasis. First, polyunsaturated fatty acids enhanced the recruitment of neutrophils from the circulation into the spleen via chemokine secretion. Second, they delayed neutrophil cell death in the spleen. Interestingly, these effects were not observed in mice fed a diet rich in saturated fatty acids, suggesting that the type of fat rather than the amount of fat mediates the alterations in neutrophil homeostasis. In conclusion, our results show that dietary polyunsaturated fatty acids have a strong modulatory effect on neutrophil homeostasis that may have future clinical applications.
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