Article
Nutrition & Dietetics
Sa Zhou, Jiamin Xue, Jingbo Shan, Yingxiang Hong, Wenkang Zhu, Zhiyan Nie, Yujie Zhang, Nanxi Ji, Xuegang Luo, Tongcun Zhang, Wenjian Ma
Summary: This study revealed the mechanistic link between TMAO and atherosclerosis risk, showing that TMAO induces vascular inflammation. It was found that TMAO suppresses the expression of AMPK and SIRT1, while AMPK and SIRT1 play important roles in regulating ROS and inflammation. Glutathione and probiotics can relieve TMAO-induced atherosclerosis.
Review
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: Endothelial function is crucial for systemic homeostasis and depends on the activity of tissue-specific angiocrine factors. Recent evidence highlights the relationship between endothelial factors and gut microbiota-derived molecules, particularly trimethylamine N-oxide (TMAO), which is involved in the development of endothelial dysfunction and its associated pathologies. TMAO modulates factors related to endothelial dysfunction, such as nitric oxide, adhesion molecules, and IL-6. This review presents the latest studies on the direct role of TMAO in modulating angiocrine factors involved in vascular pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yu-Chun Chang, Yi-Hsuan Chu, Chien-Cheng Wang, Chih-Hsuan Wang, You-Lin Tain, Hung-Wei Yang
Summary: The gut microbiota-derived metabolites TMAO and TMA play a critical role in CKD and hypertension. A new color-switch method was developed for the direct quantitative detection of TMAO in whole blood, showing potential clinical applications in blood TMAO monitoring for CKD patients.
Article
Nutrition & Dietetics
Seok Jong Chung, John Hoon Rim, Dajeong Ji, Sangwon Lee, Han Soo Yoo, Jin Ho Jung, KyoungWon Baik, Yonghoon Choi, Byoung Seok Ye, Young H. Sohn, Mijin Yun, Sang-Guk Lee, Phil Hyu Lee
Summary: This study found that lower baseline plasma TMAO levels are associated with faster increases in LED and tend to increase the risk for PD-dementia conversion, suggesting the prognostic implications of TMAO in early stage PD.
Article
Immunology
Qiqi Wang, Yue Sun, Tianyu Zhou, Cong Jiang, A. Lan, Wenzhou Xu
Summary: This study found that intestinal inflammation and periodontitis influence each other through a bidirectional relationship. The intestinal microbiome metabolite, TMAO, may contribute to chronic inflammation in the gut by influencing the gut microbial composition and intestinal immunity. The results suggest that TMAO may influence periodontal immunity and promote periodontal inflammation by affecting the intestinal microenvironment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Physiology
Katongo H. Mutengo, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo
Summary: The human gut microbiota and its dependant metabolite, trimethylamine N-oxide, play significant roles in the development of hypertension. This review examines the impact of the gut microbiota and trimethylamine N-oxide on hypertension pathogenesis, providing evidence from both human and animal studies. New insights into potential therapies for managing hypertension by altering the gut microbiota are also discussed.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yueqi Chen, Chuan Yang, Qijie Dai, Jiulin Tan, Ce Dou, Fei Luo
Summary: In this study, it was found that gold nanospheres (GNS) significantly prevented ovariectomy-induced osteoporosis in a gut microbiota-dependent manner. The gold nanospheres altered the gut microbial diversity and composition, reducing the abundance of TMAO-related metabolites. Lower TMAO levels alleviated bone loss by reducing inflammation response. The gold nanospheres also inhibited the release of pro-osteoclastogenic or proinflammatory cytokines. Overall, these results demonstrate the protective effects of gold nanospheres on osteoporosis as a gut microbiota modulator.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Nutrition & Dietetics
Doudou Li, Ying Lu, Shuai Yuan, Xiaxia Cai, Yuan He, Jie Chen, Qiong Wu, Di He, Aiping Fang, Yacong Bo, Peige Song, Debby Bogaert, Kostas Tsilidis, Susanna C. Larsson, Huanling Yu, Huilian Zhu, Evropi Theodoratou, Yimin Zhu, Xue Li
Summary: This study aimed to summarize the health outcomes related to circulating TMAO concentrations. It identified 6 associations with highly suggestive evidence, suggesting that TMAO may be a novel biomarker for human health conditions including all-cause mortality, hypertension, cardiovascular diseases, diabetes mellitus, cancer, and kidney function.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Medicine, General & Internal
Dionysis Matsiras, Sofia Bezati, Ioannis Ventoulis, Christos Verras, John Parissis, Effie Polyzogopoulou
Summary: Despite advances in the field, heart failure remains a significant burden due to its high morbidity and mortality rates. The role of inflammation in disease progression is not fully understood, but the gut has been implicated as a potential source of inflammation in patients with chronic heart failure. Changes in the composition of the gut microbiota, disruption of the gut barrier, and bacterial translocation could contribute to cardiac dysfunction and worsen heart failure. on the other hand, heart failure can also affect intestinal function, creating a vicious cycle. New pharmaceutical agents have been developed to reverse these intestinal changes and block inflammation cascade, with the goal of treating heart failure. This review summarizes the gut-related pathways and therapeutic interventions in heart failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Meyammai Shanmugham, Sophie Bellanger, Chen Huei Leo
Summary: Trimethylamine N-oxide (TMAO), a dietary metabolite derived from gut microbiome, is closely associated with diseases such as atherosclerosis, hypertension, diabetes, and hyperlipidemia, contributing to endothelial dysfunction. The mechanisms underlying TMAO-induced endothelial dysfunction involve inflammation and oxidative stress.
Article
Nutrition & Dietetics
Maximilien Franck, Juan De Toro-Martin, Thibault V. Varin, Veronique Garneau, Genevieve Pilon, Denis Roy, Patrick Couture, Charles Couillard, Andre Marette, Marie-Claude Vohl
Summary: This study evaluated the gut microbial signatures of different TMAO responses following raspberry consumption. The results showed that raspberry consumption altered the gut microbial composition, which in turn affected the changes in TMAO levels.
Review
Cardiac & Cardiovascular Systems
Ruxandra Florentina Ionescu, Robert Mihai Enache, Sanda Maria Cretoiu, Dragos Cretoiu
Summary: The human microbiota consists of microorganisms found on the skin, mucosal surfaces, and other tissues, with the gut microbiota being the major component. Changes in the gut microbiota can lead to pathophysiological changes that influence the progression of various diseases, including cardiovascular diseases. miRNAs are small non-coding RNAs that play a role in regulating gene expression. The interactions between gut microbiota, miRNAs, and cardiovascular diseases have been explored.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Salma Naqvi, Turky Omar Asar, Vikas Kumar, Fahad A. Al-Abbasi, Sultan Alhayyani, Mohammad Amjad Kamal, Firoz Anwar
Summary: This article discusses the role of gut microbiota in hypertension and cardiovascular diseases, highlighting the importance of SCFAs and TMAO. Dietary interventions can regulate gut microbiota and prevent cardiovascular complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang
Summary: Cardiovascular diseases (CVDs) are highly prevalent worldwide, and the balance of intestinal microecology plays a crucial role in their occurrence and development. Trimethylamine N-oxide (TMAO), a metabolite produced by gut microbiota from dietary choline and L-carnitine, has been found to inhibit cholesterol metabolism, induce platelet aggregation, and promote atherosclerosis. This review provides insights into the biological and chemical characteristics of TMAO, as well as its impact on various CVDs, including atherosclerosis, heart failure, hypertension, arrhythmia, and coronary artery disease. Understanding the mechanism of TMAO in promoting CVDs may contribute to the development of targeted therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xin Zhao, Patrick Kwabena Oduro, Wanyu Tong, Yuefei Wang, Xiumei Gao, Qilong Wang
Summary: Gut microbiota plays a crucial role in maintaining human health and affecting pathological outcomes, particularly in metabolic or cardiovascular diseases. Restoring the gut microbiota ecosystem can decrease the incidence of cardiovascular diseases such as atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi
Summary: The study indicates that higher intake of dietary Total Antioxidant Capacity (TAC) is associated with reduced risk of different types of cancers in meta-analysis of observational studies.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Mandi Vajdi, Mandieh Abbasalizad Farhangi, Leila Nikniaz
BMC ENDOCRINE DISORDERS
(2020)
Review
Nutrition & Dietetics
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi, Pourya Fathollahi
Summary: In this meta-analysis, it was found that higher dietary total antioxidant capacity (TAC) was associated with reduced prevalence of central obesity, reduced waist circumference and triglyceride concentrations. The study also identified potential sources of heterogeneity.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2022)
Review
Nutrition & Dietetics
Mahsa Mahmoudi-Nezhad, Mahdi Vajdi, Mahdieh Abbasalizad Farhangi
Summary: This systematic review and dose-response meta-analysis found that ALA supplementation significantly reduced insulin and insulin resistance in adults, with duration-dependent effects. However, it did not have a significant impact on glucose or HbA(1C). Subgroup analysis identified factors like ALA dosage, supplementation duration, participant health status, geographic locations and study quality as potential sources of heterogeneity.
Review
Pharmacology & Pharmacy
Fateme Kooshki, Helda Tutunchi, Mahdi Vajdi, Arash Karimi, Hamid Reza Niazkar, Hamed Shoorei, Bahram Pourghassem Gargari
Summary: The study found that chromium supplementation can reduce oxidative stress indices in diabetes mellitus, significantly increase antioxidant enzyme activity, and improve levels of antioxidant indices.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Review
Nutrition & Dietetics
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi
Summary: The meta-analysis found a positive association between circulating TMAO levels and increased risk of hypertension and other cardiometabolic disorders in adults. High TMAO concentrations were also associated with changes in blood pressure and lipid levels.
Review
Pediatrics
Leila Nikniaz, Mahdieh Abbasalizad-Farhangi, Mahdi Vajdi, Zeinab Nikniaz
Summary: The study found an association between high consumption of sugar-sweetened beverages (SSBs) and serum lipid levels in children and youth, with high intake linked to increased low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC).
Review
Nutrition & Dietetics
Mahdi Vajdi, Mahsa Mahmoudi-Nezhad, Mahdieh Abbasalizad Farhangi
Summary: This systematic review and meta-analysis evaluated the effects of alpha-lipoic acid (ALA) supplementation on inflammatory markers. The findings showed that ALA supplementation significantly reduced CRP, IL-6, and TNF-alpha concentrations in adults. There was no evidence of a non-linear association between dose or duration of supplementation and the effects on inflammatory markers.
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Naeini, Helda Tutunchi, Hamidreza Razmi, Ata Mahmoodpoor, Mahdi Vajdi, Pouria Sefidmooye Azar, Farzad Najifipour, Ali Tarighat-Esfanjani, Arash Karimi
Summary: Nano-curcumin supplementation has a beneficial effect on hematological indices and inflammatory biomarkers in critically ill patients with sepsis, making it a potentially useful adjuvant therapy. However, more trials are needed to further explore the effects of nano-curcumin in the management of sepsis and its complications.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Leila Nikniaz, Trias Mahmudiono, Saade Abdalkareem Jasim, Mahdi Vajdi, Lakshmi Thangavelu, Mahdieh Abbasalizad Farhangi
Summary: Although there is a relationship between nutrient patterns and metabolic risk factors, there is no significant association between nutrient patterns and MetS in apparently healthy obese adults. However, the simple sugar and fat based patterns have a deleterious effect on metabolic risk factors, while the mineral based pattern is associated with healthier metabolic factors.
BMC ENDOCRINE DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Arash Karimi, Helda Tutunchi, Fatemeh Naeini, Mahdi Vajdi, Majid Mobasseri, Farzad Najafipour
Summary: This systematic review suggests that resveratrol supplementation in patients with polycystic ovary syndrome (PCOS) may have therapeutic effects by regulating biological pathways, reducing insulin resistance, improving dyslipidemia, regulating reproductive hormones, reducing inflammation, and oxidative stress. However, further studies are needed to determine the exact mechanism of resveratrol in PCOS patients.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Rheumatology
Arash Karimi, Pouria Sefidmooye Azar, Mahtab Kadkhodayi, Arash Tandorost, Mahdi Vajdi, Hamed Shoorei, Mahdieh Abbasalizad Farhangi
Summary: This systematic review summarizes the effects of resveratrol supplementation on complications of rheumatoid arthritis (RA). The review suggests that resveratrol supplementation may have beneficial effects on RA complications by reducing inflammation and oxidative stress, modulating the immune response, and down-regulating the expression of genes related to inflammatory pathways. However, due to the limited number of human studies, further clinical trials are warranted.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Review
Medicine, Research & Experimental
Vali Musazadeh, Arash Karimi, Nasim Bagheri, Jaber Jafarzadeh, Sarvin Sanaei, Mahdi Vajdi, Mozhde Karimi, Hamid Reza Niazkar
Summary: This review examines the potential therapeutic effects of silymarin on COVID-19 by targeting oxidative stress, inflammation, and immune system dysfunctions. The findings suggest that silymarin may improve antioxidant capacity, attenuate inflammatory response, and enhance immune system function. Additionally, silymarin has the potential to inhibit viral replication by binding to target proteins of SARS-CoV-2. Further clinical trials are needed to validate these findings.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nutrition & Dietetics
Vali Musazadeh, Zeynab Kavyani, Behnaz Naghshbandi, Parvin Dehghan, Mahdi Vajdi
Summary: This article presents an umbrella meta-analysis that suggests n-3 PUFAs supplementation may have a role in reducing blood pressure. The analysis shows significant reductions in both systolic and diastolic blood pressure following n-3 PUFAs supplementation, particularly in studies with smaller sample sizes and older participants.
FRONTIERS IN NUTRITION
(2022)
