Review
Gastroenterology & Hepatology
Fatima B. Saldana-Morales, Dasom V. Kim, Ming-Ting Tsai, Gretchen E. Diehl
Summary: A coordinated response between the epithelium, immune system, and enteric nervous system is crucial for proper intestinal function during both health and disease. These systems work together to support digestion and recovery following injury or pathogenic infections by responding to common stimuli.
Review
Allergy
Laura R. Dowling, Michael R. Strazzari, Simon Keely, Gerard E. Kaiko
Summary: The gut-brain axis refers to the bidirectional interaction between the intestinal environment, including the epithelium, immune system, microbiota, and the enteric nervous system. This interaction plays a crucial role in linking environmental stimuli and nervous system function, as well as providing feedback from the brain to intestinal activities. The gut microbiota has a profound influence on these processes, which has not been extensively studied. Disruption of the gut microbiota is associated with both gut diseases and brain symptoms such as neurodegenerative and behavioral disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Microbiology
Jacques Gonzales, Justine Marchix, Laetitia Aymeric, Catherine Le Berre-Scoul, Johanna Zoppi, Philippe Bordron, Marie Burel, Laetitia Davidovic, Jean-Romain Richard, Alexandru Gaman, Florian Lejuste, Julie Z. Brouillet, Francoise Le Vacon, Samuel Chaffron, Marion Leboyer, Helene Boudin, Michel Neunlist
Summary: Research indicated that changes in the microbiota composition in adult ASD patients may lead to gastrointestinal alterations and remodeling of the enteric nervous system (ENS).
Article
Cell & Tissue Engineering
Meryem B. Baghdadi, Arshad Ayyaz, Sabrina Coquenlorge, Bonnie Chu, Sandeep Kumar, Catherine Streutker, Jeffrey L. Wrana, Tae-Hee Kim
Summary: This study investigates the heterogeneity and regulation of enteric glial cells (EGCs) in the intestine during homeostasis and chronic inflammatory bowel disease. A specific subset of glial cells, expressing GFAP, is found to regulate the repair potential of intestinal stem cells (ISCs) through the expression of WNT ligands. The dynamically regulated heterogeneity of EGCs is revealed to be a key part of the intestinal stem cell niche in regeneration and disease.
Review
Biochemistry & Molecular Biology
Tinh Thi Nguyen, Peter Baumann, Oliver Tuescher, Sandra Schick, Kristina Endres
Summary: The gut and the brain communicate through various channels and interactions, collectively known as the gut-brain axis. The aging of the enteric nervous system (ENS) in the gut can lead to gastrointestinal dysfunction and contribute to age-related diseases of the brain. Understanding the mechanisms of the aging ENS can provide insights into the diagnosis and treatment of neurodegenerative diseases like Alzheimer's and Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Xindi Wang, Chenbo Ding, Hua-Bing Li
Summary: The gut is a crucial organ for digestion, immunity, and metabolism. The interaction between the enteric nervous system (ENS) and immune cells plays a vital role in maintaining intestinal homeostasis and preventing diseases. This review summarizes the importance of ENS-immune cell interactions in intestinal development and diseases, providing insights for potential immunotherapy targeting the ENS.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Nutrition & Dietetics
Monica Cerutti Martellet, Fernanda Majolo, Rodrigo Gay Ducati, Claucia Fernanda Volken de Souza, Marcia Ines Goettert
Summary: This article highlights the importance of using probiotics associated with fibers from Psyllium as prebiotics to maintain a healthy intestinal microbiota. The combination has the potential to remedy imbalances in gastrointestinal tract diseases by reducing the adhesion of pathogenic microorganisms. Coating technologies and encapsulating materials can increase the survival rate of these strains in the gastrointestinal tract.
Review
Neurosciences
Luisa Seguella, Irene Palenca, Silvia Basili Franzin, Aurora Zilli, Giuseppe Esposito
Summary: Enteric glia, a unique population of peripheral neuroglia, display plastic and adaptative abilities, undergo phenotypic and functional changes, and engage in dynamic signaling with neurons and neighboring cells within the intestinal wall. They serve important roles in maintaining local homeostasis and sensing signals from luminal microbes, although further investigation is needed to fully understand this communication.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Sabrina S. B. Poon, Lin Y. Hung, Qinglong Wu, Pavitha Parathan, Nazli Yalcinkaya, Anthony Haag, Ruth Ann Luna, Joel C. Bornstein, Tor C. Savidge, Jaime P. P. Foong
Summary: Infants and young children have the highest exposure to antibiotics globally. Early life exposure to antibiotics increases susceptibility to various diseases, especially gut disorders. This study on mice found that neonatal antibiotic treatment has long-term effects on gut function, the enteric nervous system, gut microbiota, and mucosal serotonin levels in young adulthood.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Biochemistry & Molecular Biology
Atchariya Chanpong, Osvaldo Borrelli, Nikhil Thapar
Summary: The enteric nervous system (ENS) is a critical nervous system in the gastrointestinal tract that controls key functions and is affected by the microbiota and other nervous systems. Its development during early life plays a significant role in human health and disease. Dysbiosis and pathogenic microorganisms may impact the integrity and function of the ENS. This article explores the relationship between the development and integrity of the ENS and the potential impact of dysbiosis and pathogenic microorganisms.
Article
Medicine, Research & Experimental
Jinzhao Bai, Yajie Cai, Zhiyan Huang, Yiqing Gu, Nana Huang, Rong Sun, Guimin Zhang, Runping Liu
Summary: Shouhui Tongbian Capsule (SHTB) effectively improves constipation symptoms and promotes gastrointestinal motility by modulating gut microbiota and serotonin (5-HT) levels.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Yukiko Ohara, Lisa Fujimura, Akemi Sakamoto, Youichi Teratake, Shuichi Hiraoka, Haruhiko Koseki, Takeshi Saito, Keita Terui, Tetsuya Mitsunaga, Mitsuyuki Nakata, Hideo Yoshida, Masahiko Hatano
Summary: The study found that the megacolon and enteric neuron hyperplasia in KO mice are influenced by genetic background. BALB/c KO mice may serve as a valuable model for functional gastrointestinal diseases such as chronic constipation, aiding in research on underlying mechanisms and providing a foundation for treatment development.
SCIENTIFIC REPORTS
(2021)
Review
Agriculture, Dairy & Animal Science
Michael H. Kogut, Mariano Enrique Fernandez Miyakawa
Summary: The gastrointestinal ecosystem involves interactions between the host, gut microbiota, and external environment. Paratyphoid Salmonella in chickens have evolved a unique survival strategy, minimizing the inflammatory response during the initial infection to enhance disease resistance and inducing immunometabolic reprogramming to alter host defense and facilitate asymptomatic carriage of the bacterial pathogen.
Review
Virology
Mikal A. Woods Acevedo, Julie K. Pfeiffer
Summary: Enteric viruses are significant human pathogens that infect the gastrointestinal tract, where the microbiota play a crucial role in their replication, pathogenesis, and transmission. The abundance and composition of the microbiota are also important for the host immune system, which may impact the infection of enteric viruses.
CURRENT OPINION IN VIROLOGY
(2021)
Review
Geriatrics & Gerontology
Zi-Han Geng
Summary: The GI tract plays a crucial role in maintaining the stable intestinal microenvironment and its microbiota may have potential impacts on neurological diseases. However, the causal relationship between microbial changes and neurological disorders remains inconclusive at present.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Gastroenterology & Hepatology
Magdy El-Salhy, Tarek Mazzawi
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2018)
Article
Multidisciplinary Sciences
Tarek Mazzawi, Gulen Arslan Lied, Dag Andre Sangnes, Magdy El-Salhy, Johannes R. Hov, Odd Helge Gilja, Jan Gunnar Hatlebakk, Trygve Hausken
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Trygve Hausken, Johannes R. Hov, Jorgen Valeur, Dag Andre Sangnes, Magdy El-Salhy, Odd Helge Gilja, Jan Gunnar Hatlebakk, Gulen Arslan Lied
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Oystein Eikrem, Gulen Arslan Lied, Trygve Hausken
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2020)
Editorial Material
Gastroenterology & Hepatology
Tarek Mazzawi, Auamduan Chaiyapo, Pradermchai Kongkam, Wiriyaporn Ridtitid, Rungsun Rerknimitr
ARAB JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Auamduan Chaiyapo, Pradermchai Kongkam, Wiriyaporn Ridtitid, Rungsun Rerknimitr
ARAB JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Trygve Hausken, Magdy El-Salhy
Summary: This study aimed to investigate the effect of fecal microbiota transplantation (FMT) on colonic enteroendocrine cells densities in patients with irritable bowel syndrome (IBS). The results showed significant changes in colonic enteroendocrine cells densities in the group of responders who received donor-FMT. However, the mechanisms behind the interaction between gut microbiota and colonic enteroendocrine cells still need further investigation.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Tarek Mazzawi, Trygve Hausken, Jan Gunnar Hatlebakk
Summary: This study aimed to investigate the differences in FMT response between patients with severe and moderate IBS symptoms. The results showed that patients with severe symptoms had a higher response rate to FMT and experienced significant improvement in fatigue and quality of life.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Article
Microbiology
Tarek Mazzawi, Trygve Hausken, Per Forde Refsnes, Jan Gunnar Hatlebakk, Gulen Arslan Lied
Summary: This study compared the efficacy and safety of ACHIM suspension, donor-FMT, and placebo in the treatment of IBS. The results showed that all three treatment methods improved the symptoms and gut microbiota profile of IBS patients, but donor-FMT and ACHIM were more significant compared to placebo.
Article
Gastroenterology & Hepatology
Tarek Mazzawi, Carl Erik Markhus, Roald F. Havre, Khanh Do-Cong Pham
ENDOSCOPY INTERNATIONAL OPEN
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tarek Mazzawi, Emily Bartsch, Sara Benammi, Rosa Maria Carrasco Ferro, Ekaterina Nikitina, Nancy Nimer, Lara Jimenez Ortega, Charles Perrotte, Joao Vitor Pithon, Safira Rosallna, Alexis Sharp, Reza Stevano, Jan Gunnar Hatlebakk, Trygve Hausken
ULTRASOUND INTERNATIONAL OPEN
(2019)
Meeting Abstract
Gastroenterology & Hepatology
T. Mazzawi, G. Lied Arslan, J. R. Hov, J. Valeur, D. A. Sangnes, M. El-Salhy, O. H. Gilja, J. G. Hatlebakk, T. Hausken
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Roald F. Havre, Hilde K. Gjelberg, Trond Engjom, Tarek Mazzawi, Dag Hoem, Kim Waardal, Anders Molven, Khanh Cong Do Pham
GASTROINTESTINAL ENDOSCOPY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
M. El-Salhy, P. Holger Johnsen, T. Mazzawi, M. El-Salhy, T. Hausken, R. Goll, P. C. Valle
NEUROGASTROENTEROLOGY AND MOTILITY
(2017)