A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases

Intestinal epithelial barrier integrity investigated by label-free techniques in ulcerative colitis patients

(2023) Elsie Quansah et al.   Scientific Reports

cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging

(2023) Carine Raquel Richter Schmitz et al.   Frontiers in Immunology

Diagnostic Criteria and Prognostic Relevance of Sarcopenia in Patients with Inflammatory Bowel Disease—A Systematic Review

(2023) Claudia-Gabriela Potcovaru et al.   Journal of Clinical Medicine

The role of cellular senescence and SASP in tumour microenvironment

(2022) Masaki Takasugi et al.   FEBS Journal

Telomere dysfunction in ageing and age-related diseases

(2022) Francesca Rossiello et al.   NATURE CELL BIOLOGY

Interconnections between Inflammageing and Immunosenescence during Ageing

(2022) Thibault Teissier et al.   Cells

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Cellular senescence: the good, the bad and the unknown

(2022) Weijun Huang et al.   Nature Reviews Nephrology

Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening

(2022) Ryan P. Barnes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche

(2022) Nancy C. Allen et al.   Frontiers in Cell and Developmental Biology

A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?

(2022) Leah S. Hohman et al.   AGING CELL

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

Molecular Aspects of Senescence and Organismal Ageing—DNA Damage Response, Telomeres, Inflammation and Chromatin

(2021) Natalia Sławińska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactoferrin: an overview o its main functions, immunomodulatory and antimicrobial role, and clinical significance

(2021) Michał Sienkiewicz et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Roles of Macrophages in the Development and Treatment of Gut Inflammation

(2021) Xuebing Han et al.   Frontiers in Cell and Developmental Biology

Aging and IBD: A New Challenge for Clinicians and Researchers

(2021) Adam S Faye et al.   INFLAMMATORY BOWEL DISEASES

Biological functions of therapy-induced senescence in cancer

(2021) Eleni Fitsiou et al.   SEMINARS IN CANCER BIOLOGY

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Telomeres: New players in immune-mediated inflammatory diseases?

(2021) Anne-Charlotte Heba et al.   JOURNAL OF AUTOIMMUNITY

Importance of Telomere Shortening in the Pathogenesis of Ulcerative Colitis: A New Treatment From the Aspect of Telomeres in Intestinal Epithelial Cells

(2021) Sho Watanabe et al.   Journal of Crohns & Colitis

Telomere dysfunction instigates inflammation in inflammatory bowel disease

(2021) Deepavali Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Intestinal Macrophages in Gastrointestinal Homeostasis: Heterogeneity and Implications in Disease

(2021) Jackson L.K. Yip et al.   Cellular and Molecular Gastroenterology and Hepatology

Stress and telomere shortening: Insights from cellular mechanisms

(2021) Jue Lin et al.   AGEING RESEARCH REVIEWS

Mechanisms and Regulation of Cellular Senescence

(2021) Lauréline Roger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice

(2020) Ailing Liu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The mTOR pathway is necessary for survival of mice with short telomeres

(2020) Iole Ferrara-Romeo et al.   Nature Communications

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

(2020) Rosa Maria Porreca et al.   eLife

Telomeres and Telomere Length: A General Overview

(2020) Nalini Srinivas et al.   Cancers

Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review

(2020) Mateo Amaya-Montoya et al.   ADVANCES IN THERAPY

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

(2020) Jing Zhao et al.   Aging-US

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

Life, death, and autophagy in cancer: NF-κB turns up everywhere

(2020) Daniela Verzella et al.   Cell Death & Disease

Twenty years of t-loops: A case study for the importance of collaboration in molecular biology

(2020) Ľubomír Tomáška et al.   DNA REPAIR

Ageing, metabolism and the intestine

(2020) Maja C Funk et al.   EMBO REPORTS

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

(2020) Bing Zhang et al.   GUT

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

(2020) Salim Abdisalaam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

Senescence and Host–Pathogen Interactions

(2020) Daniel Humphreys et al.   Cells

A guide to assessing cellular senescence in vitro and in vivo

(2020) Estela González‐Gualda et al.   FEBS Journal

The four epidemiological stages in the global evolution of inflammatory bowel disease

(2020) Gilaad G. Kaplan et al.   Nature Reviews Gastroenterology & Hepatology

Telomere dysfunction activates YAP1 to drive tissue inflammation

(2020) Deepavali Chakravarti et al.   Nature Communications

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescent cells and macrophages: key players for regeneration?

(2020) Sonia S. Elder et al.   Open Biology

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

(2020) Lorenzo Cuollo et al.   Biology-Basel

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Inflammatory Bowel Disease Presentation and Diagnosis

(2019) Sean Flynn et al.   SURGICAL CLINICS OF NORTH AMERICA

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Senescent Stem and Transient Amplifying Cells in Crohn’s Disease Intestine

(2019) Xiaoyan Wang et al.   INFLAMMATORY BOWEL DISEASES

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease

(2018) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome

(2018) Larissa S. Celiberto et al.   IMMUNOLOGY

Sarcopenia and Inflammatory Bowel Disease: A Systematic Review

(2018) Eanna Ryan et al.   INFLAMMATORY BOWEL DISEASES

The impact of oxidative DNA damage and stress on telomere homeostasis

(2018) Ryan P. Barnes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Role of Senescence, Telomere Dysfunction and Shelterin in Vascular Aging

(2018) Yu Liu et al.   MICROCIRCULATION

Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

(2018) D. Bernardo et al.   Mucosal Immunology

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

(2018) Jodie Birch et al.   PHARMACOLOGY & THERAPEUTICS

Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1α/TNFAIP3 Axis

(2018) Yanhua Kang et al.   Cell Reports

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

(2018) Dominick G. A. Burton et al.   BIOGERONTOLOGY

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

(2017) Bernadette Carroll et al.   JOURNAL OF CELL BIOLOGY

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Environmental triggers in IBD: a review of progress and evidence

(2017) Ashwin N. Ananthakrishnan et al.   Nature Reviews Gastroenterology & Hepatology

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

(2017) Nina Frey et al.   Nature Reviews Gastroenterology & Hepatology

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeres and Cell Senescence - Size Matters Not

(2017) Stella Victorelli et al.   EBioMedicine

Intestinal Barrier Dysfunction in Human Pathology and Aging

(2016) Marcel Cerqueira César Machado et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Role of Monocytes and Intestinal Macrophages in Crohnʼs Disease and Ulcerative Colitis

(2016) Susanne T. Gren et al.   INFLAMMATORY BOWEL DISEASES

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

(2015) Paola Lucia Minciullo et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length.

(2015) Zoraida Verde et al.   ENVIRONMENTAL RESEARCH

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

(2015) Timothy Nacarelli et al.   EXPERIMENTAL GERONTOLOGY

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization

(2015) Alessandra Galati et al.   NUCLEIC ACIDS RESEARCH

Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease

(2015) Cristina-Sorina Cătană et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

Essential role for the TRF2 telomere protein in adult skin homeostasis

(2014) Paula Martínez et al.   AGING CELL

Blood cell telomere lengths and shortening rates of chimpanzee and human females

(2014) Justin Tackney et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis

(2014) Mariann Friis-Ottessen et al.   BMC GASTROENTEROLOGY

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke

(2014) Alex Dregan et al.   CIRCULATION

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma

(2014) Natasa D Zdravkovic et al.   International Journal of Medical Sciences

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial Metaplasia

(2014) Luigi Mari et al.   Cell Reports

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis

(2012) Samira Tamoutounour et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Risk of ischaemic heart disease in patients with inflammatory bowel disease: a nationwide Danish cohort study

(2012) Christine Rungoe et al.   GUT

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

(2012) Ehud Zigmond et al.   IMMUNITY

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat

(2012) Shuai Xiang et al.   PLoS One

Ageing and the gut

(2012) Edward Britton et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Mechanisms of telomere loss and their consequences for chromosome instability

(2012) Keiko Muraki et al.   Frontiers in Oncology

Ulcerative Colitis-Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation

(2011) R. A. Risques et al.   CANCER RESEARCH

CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions

(2011) Benjamin Weber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

(2011) Jason A. Stewart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Shelterin complex and associated factors at human telomeres

(2011) Raffaella Diotti et al.   Nucleus

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Epithelial Barriers in Homeostasis and Disease

(2010) Amanda M. Marchiando et al.   Annual Review of Pathology-Mechanisms of Disease

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease

(2010) Nancy Da-Silva et al.   DIGESTIVE AND LIVER DISEASE

Importance of disrupted intestinal barrier in inflammatory bowel diseases

(2010) Saʼad Y. Salim et al.   INFLAMMATORY BOWEL DISEASES

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation

(2010) A. M. Platt et al.   JOURNAL OF IMMUNOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer

(2009) Lisa Mirabello et al.   AGING CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA Damage

(2008) Rosa Ana Risques et al.   GASTROENTEROLOGY

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY