Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
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Title
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
Authors
Keywords
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Journal
ADVANCES IN THERAPY
Volume 37, Issue 4, Pages 1407-1424
Publisher
Springer Science and Business Media LLC
Online
2020-03-18
DOI
10.1007/s12325-020-01287-0
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Note: Only part of the references are listed.- Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
- (2019) Allyson K. Palmer et al. AGING CELL
- The senescence-associated secretory phenotype and its regulation
- (2019) Stéphane Lopes-Paciencia et al. CYTOKINE
- Cellular Senescence: Aging, Cancer, and Injury
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- (2019) Larissa G.P. Langhi Prata et al. SEMINARS IN IMMUNOLOGY
- From discoveries in ageing research to therapeutics for healthy ageing
- (2019) Judith Campisi et al. NATURE
- Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
- (2019) Mikolaj Ogrodnik et al. TRENDS IN BIOCHEMICAL SCIENCES
- Hallmarks of senescence and aging
- (2019) Slavica Dodig et al. Biochemia Medica
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Targeting normal and cancer senescent cells as a strategy of senotherapy
- (2019) Ewa Sikora et al. AGEING RESEARCH REVIEWS
- Regulation of senescence and the SASP by the transcription factor C/EBPβ
- (2019) Jacqueline Salotti et al. EXPERIMENTAL GERONTOLOGY
- The development of cell senescence
- (2019) Sabela Da Silva-Álvarez et al. EXPERIMENTAL GERONTOLOGY
- Cellular senescence and senescence‐associated T cells as a potential therapeutic target
- (2019) Hironori Nakagami Geriatrics & Gerontology International
- Anti-senescence compounds: A potential nutraceutical approach to healthy aging
- (2018) Felicia Gurău et al. AGEING RESEARCH REVIEWS
- The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
- (2018) Luigi Fontana et al. AGING CELL
- Cellular senescence: a view throughout organismal life
- (2018) Cayetano von Kobbe CELLULAR AND MOLECULAR LIFE SCIENCES
- Regulation of cellular senescence via the FOXO4-p53 axis
- (2018) Benjamin Bourgeois et al. FEBS LETTERS
- Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
- (2018) Carmen Mecca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis
- (2018) Sundeep Khosla et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Mechanisms and functions of cellular senescence
- (2018) Nicolás Herranz et al. JOURNAL OF CLINICAL INVESTIGATION
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
- (2018) Shankar J. Chinta et al. Cell Reports
- Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
- (2018) Dominick G. A. Burton et al. BIOGERONTOLOGY
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Fisetin is a senotherapeutic that extends health and lifespan
- (2018) Matthew J. Yousefzadeh et al. EBioMedicine
- Caloric restriction and cellular senescence
- (2018) Luigi Fontana et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Interleukin-6 Family Cytokines
- (2017) Stefan Rose-John Cold Spring Harbor Perspectives in Biology
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
- (2017) Claudio A. Valenzuela et al. Frontiers in Oncology
- Cellular senescence impact on immune cell fate and function
- (2016) Rita Vicente et al. AGING CELL
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
- (2016) Servet Özcan et al. Aging-US
- Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
- (2016) Ansar Karimian et al. DNA REPAIR
- The cell fate: senescence or quiescence
- (2016) Menderes Yusuf Terzi et al. MOLECULAR BIOLOGY REPORTS
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases
- (2016) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence
- (2016) Priyanka L. Patel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
- (2016) Lluc Mosteiro et al. SCIENCE
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Adult-onset, short-term dietary restriction reduces cell senescence in mice
- (2016) Chunfang Wang et al. Aging-US
- Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial
- (2015) Luigi Fontana et al. AGING CELL
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease
- (2015) Olivier Pluquet et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Loss-of-Function Mutations in the Cell-Cycle Control GeneCDKN2AImpact on Glucose Homeostasis in Humans
- (2015) Aparna Pal et al. DIABETES
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- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2014) Duc Tran et al. AGING CELL
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- (2014) Y Hassona et al. BRITISH JOURNAL OF CANCER
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- (2014) B. G. Childs et al. EMBO REPORTS
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
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- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2013) Olga Moiseeva et al. AGING CELL
- Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
- (2013) P. D. Angelini et al. CANCER RESEARCH
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Chemokine–Chemokine Receptor CCL2–CCR2 and CX3CL1–CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis
- (2013) Motoko Sasaki et al. DIGESTIVE DISEASES AND SCIENCES
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging
- (2012) Herminia González-Navarro et al. AGING CELL
- Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
- (2012) Diana Jurk et al. AGING CELL
- Astrocyte Senescence as a Component of Alzheimer’s Disease
- (2012) Rekha Bhat et al. PLoS One
- Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
- (2012) S. Rajagopalan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differentiation of Human Adipose-Derived Stem Cells into Fat Involves Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of Antioxidant Enzymes
- (2012) Masayoshi Higuchi et al. STEM CELLS AND DEVELOPMENT
- Cellular senescence and tumor suppressor gene p16
- (2011) Hani Rayess et al. INTERNATIONAL JOURNAL OF CANCER
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
- (2011) Simon A. Jones et al. JOURNAL OF CLINICAL INVESTIGATION
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Growth stimulation leads to cellular senescence when the cell cycle is blocked
- (2010) Zoya N. Demidenko et al. CELL CYCLE
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
- (2010) Andrea Alimonti et al. JOURNAL OF CLINICAL INVESTIGATION
- The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
- (2010) Joon-Il Jun et al. NATURE CELL BIOLOGY
- The DNA-damage response in human biology and disease
- (2009) Stephen P. Jackson et al. NATURE
- A crucial role for adipose tissue p53 in the regulation of insulin resistance
- (2009) Tohru Minamino et al. NATURE MEDICINE
- Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats
- (2009) Adam D. Bachstetter et al. NEUROBIOLOGY OF AGING
- Cell surface-bound IL-1 is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
- (2009) A. V. Orjalo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer
- (2008) Q Chang et al. BRITISH JOURNAL OF CANCER
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Many roads lead to oncogene-induced senescence
- (2008) S Courtois-Cox et al. ONCOGENE
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