Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening

Cellular senescence: all roads lead to mitochondria

(2022) Hélène Martini et al.   FEBS Journal

Telomere dysfunction in ageing and age-related diseases

(2022) Francesca Rossiello et al.   NATURE CELL BIOLOGY

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

(2021) Anthony Lagnado et al.   EMBO JOURNAL

Causes and consequences of micronuclei

(2021) Ksenia Krupina et al.   CURRENT OPINION IN CELL BIOLOGY

Cytoplasmic DNA: sources, sensing, and role in aging and disease

(2021) Karl N. Miller et al.   CELL

Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress

(2021) Mariarosaria De Rosa et al.   Frontiers in Cell and Developmental Biology

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

(2020) Rosa Maria Porreca et al.   eLife

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Break-induced replication promotes fragile telomere formation

(2020) Zhe Yang et al.   GENES & DEVELOPMENT

The end protection problem—an unexpected twist in the tail

(2020) Phil Ruis et al.   GENES & DEVELOPMENT

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

(2020) Tina Wagner et al.   PLoS Genetics

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Aged-senescent cells contribute to impaired heart regeneration

(2019) Fiona C. Lewis-McDougall et al.   AGING CELL

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

(2019) Elise Fouquerel et al.   MOLECULAR CELL

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

(2019) Wei Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial peptides modulate mitochondrial function during cellular senescence

(2018) Su-Jeong Kim et al.   Aging-US

Impact of oxidative stress on telomere biology

(2018) Wareed Ahmed et al.   DIFFERENTIATION

The impact of oxidative DNA damage and stress on telomere homeostasis

(2018) Ryan P. Barnes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Telomere Loop Dynamics in Chromosome End Protection

(2018) David Van Ly et al.   MOLECULAR CELL

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism

(2018) Özgün Özer et al.   Oncotarget

Urinary 8-oxo-7,8-dihydroguanosine as a Potential Biomarker of Aging

(2018) Wei Gan et al.   Frontiers in Aging Neuroscience

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Telomeres Increasingly Develop Aberrant Structures in Aging Humans

(2018) Virginia Boccardi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

(2017) Gireedhar Venkatachalam et al.   NUCLEIC ACIDS RESEARCH

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

A method for measuring the distribution of the shortest telomeres in cells and tissues

(2017) Tsung-Po Lai et al.   Nature Communications

A genetically targetable near-infrared photosensitizer

(2016) Jianjun He et al.   NATURE METHODS

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

(2016) Alexandra M. Pinzaru et al.   Cell Reports

Oxidation as “The Stress of Life”

(2016) Nikolay L. Malinin et al.   Aging-US

Oxidative DNA damage stalls the human mitochondrial replisome

(2016) Gorazd Stojkovič et al.   Scientific Reports

Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells

(2015) Shin-ichiro Takebayashi et al.   AGING CELL

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

(2015) Jodie Birch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway

(2015) Wen-Cheng Chou et al.   CARCINOGENESIS

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

(2013) Anthony J. Cesare et al.   MOLECULAR CELL

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

(2013) J. Cadet et al.   Cold Spring Harbor Perspectives in Biology

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells

(2012) Eleonora Parlanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

(2012) Muralidhar L. Hegde et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA damage by singlet oxygen and cellular protective mechanisms

(2012) Lucymara F. Agnez-Lima et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

A switch between DNA polymerases   and   promotes error-free bypass of 8-oxo-G lesions

(2012) E. Markkanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Five dysfunctional telomeres predict onset of senescence in human cells

(2011) Zeenia Kaul et al.   EMBO REPORTS

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

High fidelity and lesion bypass capability of human DNA polymerase δ

(2009) Michael W. Schmitt et al.   BIOCHIMIE

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases   and  

(2009) S. D. McCulloch et al.   NUCLEIC ACIDS RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Characterization of chromosomes and chromosomal fragments in human lymphocyte micronuclei by telomeric and centromeric FISH

(2008) H. K. Lindberg et al.   MUTAGENESIS