The role of cellular senescence and SASP in tumour microenvironment
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Title
The role of cellular senescence and SASP in tumour microenvironment
Authors
Keywords
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Journal
FEBS Journal
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2022-02-02
DOI
10.1111/febs.16381
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Note: Only part of the references are listed.- Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
- (2021) Yoshikazu Johmura et al. SCIENCE
- Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
- (2021) Tadahito Yasuda et al. Cell Reports
- Senolytics for Cancer Therapy: Is All that Glitters Really Gold?
- (2021) Valerie J. Carpenter et al. Cancers
- Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy
- (2021) Pataje G Prasanna et al. JNCI-Journal of the National Cancer Institute
- Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
- (2021) Ruchi Kumari et al. Frontiers in Cell and Developmental Biology
- HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells
- (2021) Dan-Dan Chen et al. Aging-US
- Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence
- (2021) Eliot Fletcher-Sananikone et al. CANCER RESEARCH
- A proteomic atlas of senescence-associated secretomes for aging biomarker development
- (2020) Nathan Basisty et al. PLOS BIOLOGY
- Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells
- (2020) Huilan Wang et al. Frontiers in Oncology
- Galactose‐modified duocarmycin prodrugs as senolytics
- (2020) Ana Guerrero et al. AGING CELL
- The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice
- (2020) Shota Yoshida et al. Nature Communications
- A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
- (2020) Masahiro Wakita et al. Nature Communications
- Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
- (2020) Laurent Grosse et al. Cell Metabolism
- Senolytic CAR T cells reverse senescence-associated pathologies
- (2020) Corina Amor et al. NATURE
- Senescence as a therapeutically relevant response to CDK4/6 inhibitors
- (2020) Verena Wagner et al. ONCOGENE
- Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
- (2020) Xiaohong Peng et al. Cell Death & Disease
- Cellular senescence in ageing: from mechanisms to therapeutic opportunities
- (2020) Raffaella Di Micco et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- L1 drives IFN in senescent cells and promotes age-associated inflammation
- (2019) Marco De Cecco et al. NATURE
- LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
- (2019) Matthew Simon et al. Cell Metabolism
- Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy
- (2019) Tareq Saleh et al. CANCER RESEARCH
- Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
- (2019) Lena Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Cellular Senescence: Defining a Path Forward
- (2019) Vassilis Gorgoulis et al. CELL
- Regulation of senescence and the SASP by the transcription factor C/EBPβ
- (2019) Jacqueline Salotti et al. EXPERIMENTAL GERONTOLOGY
- A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
- (2019) Sajid Khan et al. NATURE MEDICINE
- Emerging roles of extracellular vesicles in cellular senescence and aging
- (2018) Masaki Takasugi AGING CELL
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma
- (2018) Eun Kyoung Kim et al. PLoS One
- Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
- (2018) Akiko Takahashi et al. Nature Communications
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p21: A Two-Faced Genome Guardian
- (2017) Alexandros G. Georgakilas et al. TRENDS IN MOLECULAR MEDICINE
- Senescent tumor cells lead the collective invasion in thyroid cancer
- (2017) Young Hwa Kim et al. Nature Communications
- Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
- (2017) Masaki Takasugi et al. Nature Communications
- p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
- (2017) Atsushi Okuma et al. Nature Communications
- Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
- (2017) Kévin Contrepois et al. Nature Communications
- Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
- (2017) Akiko Takahashi et al. Nature Communications
- Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity
- (2017) Tze Mun Loo et al. Cancer Discovery
- Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
- (2016) Tobias Eggert et al. CANCER CELL
- Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer
- (2016) Joana Tato-Costa et al. Clinical Colorectal Cancer
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- NOTCH1 mediates a switch between two distinct secretomes during senescence
- (2016) Matthew Hoare et al. NATURE CELL BIOLOGY
- Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
- (2016) Lluc Mosteiro et al. SCIENCE
- Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
- (2016) Megan K. Ruhland et al. Nature Communications
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
- (2016) Francesco Prattichizzo et al. Oncotarget
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- (2015) C. Kang et al. SCIENCE
- Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
- (2014) Mina Sasaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Combined CDKN1A/TP53 Mutation in Bladder Cancer Is a Therapeutic Target
- (2014) Y. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
- (2014) P. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
- (2013) Ariel Pribluda et al. CANCER CELL
- Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
- (2013) Christin E. Burd et al. CELL
- Non-Cell-Autonomous Tumor Suppression by p53
- (2013) Amaia Lujambio et al. CELL
- Lysosome-mediated processing of chromatin in senescence
- (2013) Andre Ivanov et al. JOURNAL OF CELL BIOLOGY
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Lamin B1 loss is a senescence-associated biomarker
- (2012) Adam Freund et al. MOLECULAR BIOLOGY OF THE CELL
- Pathobiology of Aging Mice and GEM
- (2012) C. F. Brayton et al. VETERINARY PATHOLOGY
- Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
- (2011) Antero Salminen et al. CELLULAR SIGNALLING
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)
- (2011) M. Ohanna et al. GENES & DEVELOPMENT
- DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
- (2011) L. Litovchick et al. GENES & DEVELOPMENT
- Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity
- (2011) Y. Chien et al. GENES & DEVELOPMENT
- Cellular senescence and tumor suppressor gene p16
- (2011) Hani Rayess et al. INTERNATIONAL JOURNAL OF CANCER
- DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
- (2011) Akiko Takahashi et al. MOLECULAR CELL
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
- (2011) C Canino et al. ONCOGENE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Epigenetic regulation of theINK4b-ARF-INK4alocus
- (2010) Nikolay Popov et al. Epigenetics
- DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
- (2010) F. Rodier et al. JOURNAL OF CELL SCIENCE
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
- (2010) Andrea Alimonti et al. JOURNAL OF CLINICAL INVESTIGATION
- ATM Activation by Oxidative Stress
- (2010) Z. Guo et al. SCIENCE
- The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
- (2009) K. Agger et al. GENES & DEVELOPMENT
- Real-time in vivo imaging of p16Ink4areveals cross talk with p53
- (2009) Kimi Yamakoshi et al. JOURNAL OF CELL BIOLOGY
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
- (2008) Narendra Wajapeyee et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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