The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases
Authors
Keywords
-
Journal
Biology-Basel
Volume 9, Issue 12, Pages 485
Publisher
MDPI AG
Online
2020-12-22
DOI
10.3390/biology9120485
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
- (2020) Maria Grazia Vizioli et al. GENES & DEVELOPMENT
- Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms
- (2020) Jessica Beck et al. CARCINOGENESIS
- N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells
- (2020) Yanan Cao et al. Translational Oncology
- G3BP1 controls the senescence-associated secretome and its impact on cancer progression
- (2020) Amr Omer et al. Nature Communications
- Regulation of PD-L1 Expression by NF-κB in Cancer
- (2020) Fabrizio Antonangeli et al. Frontiers in Immunology
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
- (2019) Ji Heon Noh et al. NUCLEIC ACIDS RESEARCH
- Senescent cells: Living or dying is a matter of NK cells
- (2019) Fabrizio Antonangeli et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
- (2019) Yuk Yuen Lan et al. AGING CELL
- The senescence-associated secretory phenotype and its regulation
- (2019) Stéphane Lopes-Paciencia et al. CYTOKINE
- Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
- (2019) Lena Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
- (2019) Michela Borghesan et al. Cell Reports
- Molecular pathways of senescence regulate placental structure and function
- (2019) Hilah Gal et al. EMBO JOURNAL
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Cellular Senescence: Defining a Path Forward
- (2019) Vassilis Gorgoulis et al. CELL
- Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
- (2018) Lucia Terlecki-Zaniewicz et al. Aging-US
- PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
- (2018) Athena Georgilis et al. CANCER CELL
- CD36 initiates the secretory phenotype during the establishment of cellular senescence
- (2018) Mengyang Chong et al. EMBO REPORTS
- Strategies targeting cellular senescence
- (2018) Yossi Ovadya et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms and functions of cellular senescence
- (2018) Nicolás Herranz et al. JOURNAL OF CLINICAL INVESTIGATION
- Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells
- (2018) Anna Strzeszewska et al. Cell Death & Disease
- Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
- (2018) Akiko Takahashi et al. Nature Communications
- The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
- (2018) Boyi Zhang et al. Nature Communications
- Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans -Presentation
- (2018) Cristiana Borrelli et al. Cancer Immunology Research
- Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
- (2018) Gillian Dunphy et al. MOLECULAR CELL
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
- (2018) Jack Prescott et al. Cells
- Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
- (2018) Andrew Paul et al. Cells
- SASP regulation by noncoding RNA
- (2017) Amaresh C. Panda et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
- (2017) Selene Glück et al. NATURE CELL BIOLOGY
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- cGAS is essential for cellular senescence
- (2017) Hui Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spatial and Temporal Control of Senescence
- (2017) Yoko Ito et al. TRENDS IN CELL BIOLOGY
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability
- (2016) Hui Wang et al. AGING CELL
- Context-dependent effects of cellular senescence in cancer development
- (2016) Pacome Lecot et al. BRITISH JOURNAL OF CANCER
- From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
- (2016) Christopher D. Wiley et al. Cell Metabolism
- Mitochondria are required for pro‐ageing features of the senescent phenotype
- (2016) Clara Correia‐Melo et al. EMBO JOURNAL
- MLL1 is essential for the senescence-associated secretory phenotype
- (2016) Brian C. Capell et al. GENES & DEVELOPMENT
- HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci
- (2016) Katherine M. Aird et al. JOURNAL OF CELL BIOLOGY
- NOTCH1 mediates a switch between two distinct secretomes during senescence
- (2016) Matthew Hoare et al. NATURE CELL BIOLOGY
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
- (2016) N. Tasdemir et al. Cancer Discovery
- Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
- (2016) Fabrizio Antonangeli et al. OncoImmunology
- MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
- (2016) Dipa Bhaumik et al. Aging-US
- If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
- (2016) Vladimir N. Anisimov et al. Aging-US
- Cellular senescence: from growth arrest to immunogenic conversion
- (2015) D. G. A. Burton et al. AGE
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
- (2015) Dauren Alimbetov et al. BIOGERONTOLOGY
- Senescent cells communicate via intercellular protein transfer
- (2015) Anat Biran et al. GENES & DEVELOPMENT
- The Exocyst at a Glance
- (2015) B. Wu et al. JOURNAL OF CELL SCIENCE
- MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype
- (2015) Hongshan Chen et al. MOLECULAR CELL
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
- (2015) C. Kang et al. SCIENCE
- Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB
- (2014) Michihiro Hashimoto et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- The human long noncoding RNA lnc-IL7R regulates the inflammatory response
- (2014) Huachun Cui et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors
- (2014) Ileana Badi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
- (2014) Yingxi Xu et al. TRENDS IN BIOCHEMICAL SCIENCES
- Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4
- (2014) Joseph M. Catanzaro et al. Nature Communications
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma
- (2014) Alessandra Soriani et al. OncoImmunology
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Non-Cell-Autonomous Tumor Suppression by p53
- (2013) Amaia Lujambio et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
- (2013) X. Deschenes-Simard et al. GENES & DEVELOPMENT
- I B is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence
- (2013) E. Alexander et al. JOURNAL OF CELL SCIENCE
- p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
- (2013) Alexandre Iannello et al. JOURNAL OF EXPERIMENTAL MEDICINE
- C/EBPγ Suppresses Senescence and Inflammatory Gene Expression by Heterodimerizing with C/EBPβ
- (2013) Christopher J. Huggins et al. MOLECULAR AND CELLULAR BIOLOGY
- A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes
- (2013) S. Carpenter et al. SCIENCE
- A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
- (2013) Nicole A Rapicavoli et al. eLife
- Toll like receptor signaling in “inflammaging”: microRNA as new players
- (2013) Fabiola Olivieri et al. Immunity & Ageing
- Tristetraprolin: Roles in cancer and senescence
- (2012) Christina R. Ross et al. AGEING RESEARCH REVIEWS
- Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
- (2012) Remi-Martin Laberge et al. AGING CELL
- Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
- (2012) C. Algire et al. Cancer Prevention Research
- DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out
- (2012) Kevin W. McCool et al. IMMUNOLOGICAL REVIEWS
- NF-κB inhibition delays DNA damage–induced senescence and aging in mice
- (2012) Jeremy S. Tilstra et al. JOURNAL OF CLINICAL INVESTIGATION
- Lamin B1 loss is a senescence-associated biomarker
- (2012) Adam Freund et al. MOLECULAR BIOLOGY OF THE CELL
- MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
- (2012) M. Fabbri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 3′UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells
- (2011) Sandip K Basu et al. EMBO JOURNAL
- p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
- (2011) Adam Freund et al. EMBO JOURNAL
- Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)
- (2011) M. Ohanna et al. GENES & DEVELOPMENT
- DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
- (2011) Akiko Takahashi et al. MOLECULAR CELL
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Senescent cells as a source of inflammatory factors for tumor progression
- (2010) Albert R. Davalos et al. CANCER AND METASTASIS REVIEWS
- Feedback between p21 and reactive oxygen production is necessary for cell senescence
- (2010) João F Passos et al. Molecular Systems Biology
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo
- (2009) Laura Formentini et al. BIOCHEMICAL PHARMACOLOGY
- Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity
- (2009) Marianna N. Rossi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Cell surface-bound IL-1 is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
- (2009) A. V. Orjalo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- ATR signaling can drive cells into senescence in the absence of DNA breaks
- (2008) L. I. Toledo et al. GENES & DEVELOPMENT
- Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells
- (2008) R Chen et al. ONCOGENE
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started