TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

Expression and differential regulation of human TERRA at several chromosome ends

(2019) Marianna Feretzaki et al.   RNA

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

(2018) Pol Margalef et al.   CELL

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication

(2018) Alexander J Neil et al.   NUCLEIC ACIDS RESEARCH

Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension

(2018) Rosa M Porreca et al.   NUCLEIC ACIDS RESEARCH

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative

(2018) Luis Aragón   Annual Review of Genetics

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

PAR-TERRA directs homologous sex chromosome pairing

(2017) Hsueh-Ping Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres

(2017) Xiaolei Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAR-TERRA directs homologous sex chromosome pairing

(2017) Hsueh-Ping Chu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

(2017) Juan Lafuente-Barquero et al.   PLoS Genetics

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

(2017) Hyeung Kim et al.   Cell Discovery

Alternative lengthening of human telomeres is a conservative DNA replication process with features of break‐induced replication

(2016) Fani‐Marlen Roumelioti et al.   EMBO REPORTS

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

Rif1 Regulates the Fate of DNA Entanglements during Mitosis

(2016) Sophie Zaaijer et al.   Cell Reports

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

RNase H enables efficient repair of R-loop induced DNA damage

(2016) Jeremy D Amon et al.   eLife

Roles of human POLD1 and POLD3 in genome stability

(2016) Emanuela Tumini et al.   Scientific Reports

Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers

(2015) Paulina Marzec et al.   CELL

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

(2015) S. Tutton et al.   EMBO JOURNAL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres

(2014) Martina Stagno d´Alcontres et al.   CELL CYCLE

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

(2014) Michal Zimmermann et al.   GENES & DEVELOPMENT

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination

(2014) Dimitri Conomos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

(2014) Isabel López de Silanes et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

Structure-specific endonucleases: guardians of fragile site stability

(2013) Sheroy Minocherhomji et al.   TRENDS IN CELL BIOLOGY

Alternative lengthening of telomeres: remodeling the telomere architecture

(2013) Dimitri Conomos et al.   Frontiers in Oncology

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

(2012) Peng Wu et al.   CELL

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

(2012) Peili Gu et al.   EMBO JOURNAL

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

(2010) Carolyn J. McNees et al.   JOURNAL OF CELL BIOLOGY

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determination of enriched histone modifications in non-genic portions of the human genome

(2009) Jeffrey A Rosenfeld et al.   BMC GENOMICS

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Control of telomere length by a trimming mechanism that involves generation of t-circles

(2009) Hilda A Pickett et al.   EMBO JOURNAL

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

(2009) I. Draskovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair

(2009) Yu-Hung Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics